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Volume 12, Number 1—January 2006
THEME ISSUE
Influenza
History

1918 Influenza: the Mother of All Pandemics

Jeffery K. Taubenberger*Comments to Author  and David M. Morens†
Author affiliations: *Armed Forces Institute of Pathology, Rockville, Maryland, USA; †National Institutes of Health, Bethesda, Maryland, USA

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Figure 3

Influenza plus pneumonia (P&I) (combined) age-specific incidence rates per 1,000 persons per age group (panel A), death rates per 1,000 persons, ill and well combined (panel B), and case-fatality rates (panel C, solid line), US Public Health Service house-to-house surveys, 8 states, 1918 (36). A more typical curve of age-specific influenza case-fatality (panel C, dotted line) is taken from US Public Health Service surveys during 1928–1929 (37).

Figure 3. Influenza plus pneumonia (P&I) (combined) age-specific incidence rates per 1,000 persons per age group (panel A), death rates per 1,000 persons, ill and well combined (panel B), and case-fatality rates (panel C, solid line), US Public Health Service house-to-house surveys, 8 states, 1918 (36). A more typical curve of age-specific influenza case-fatality (panel C, dotted line) is taken from US Public Health Service surveys during 1928–1929 (37).

Main Article

References
  1. Frost  WH. Statistics of influenza morbidity. Public Health Rep. 1920;35:584–97. DOI
  2. Burnet  F, Clark  E. Influenza: a survey of the last 50 years in the light of modern work on the virus of epidemic influenza. Melbourne: MacMillan; 1942.
  3. Marks  G, Beatty  WK. Epidemics. New York: Scribners; 1976.
  4. Rosenau  MJ, Last  JM. Maxcy-Rosenau preventative medicine and public health. New York: Appleton-Century-Crofts; 1980.
  5. Crosby  A. America's forgotten pandemic. Cambridge (UK): Cambridge University Press;1989.
  6. Patterson  KD, Pyle  GF. The geography and mortality of the 1918 influenza pandemic. Bull Hist Med. 1991;65:4–21.PubMed
  7. Johnson  NPAS, Mueller  J. Updating the accounts: global mortality of the 1918–1920 "Spanish" influenza pandemic. Bull Hist Med. 2002;76:105–15. DOIPubMed
  8. Shope  RE. The incidence of neutralizing antibodies for swine influenza virus in the sera of human beings of different ages. J Exp Med. 1936;63:669–84. DOIPubMed
  9. Kendal  AP, Noble  GR, Skehel  JJ, Dowdle  WR. Antigenic similarity of influenza A (H1N1) viruses from epidemics in 1977–1978 to "Scandinavian" strains isolated in epidemics of 1950–1951. Virology. 1978;89:632–6. DOIPubMed
  10. Taubenberger  JK, Reid  AH, Krafft  AE, Bijwaard  KE, Fanning  TG. Initial genetic characterization of the 1918 "Spanish" influenza virus. Science. 1997;275:1793–6. DOIPubMed
  11. Basler  CF, Reid  AH, Dybing  JK, Janczewski  TA, Fanning  TG, Zheng  H, Sequence of the 1918 pandemic influenza virus nonstructural gene (NS) segment and characterization of recombinant viruses bearing the 1918 NS genes. Proc Natl Acad Sci U S A. 2001;98:2746–51. DOIPubMed
  12. Reid  AH, Fanning  TG, Hultin  JV, Taubenberger  JK. Origin and evolution of the 1918 "Spanish" influenza virus hemagglutinin gene. Proc Natl Acad Sci U S A. 1999;96:1651–6. DOIPubMed
  13. Reid  AH, Fanning  TG, Janczewski  TA, Lourens  RM, Taubenberger  JK. Novel origin of the 1918 pandemic influenza virus nucleoprotein gene segment. J Virol. 2004;78:12462–70. DOIPubMed
  14. Reid  AH, Fanning  TG, Janczewski  TA, McCall  S, Taubenberger  JK. Characterization of the 1918 "Spanish" influenza virus matrix gene segment. J Virol. 2002;76:10717–23. DOIPubMed
  15. Reid  AH, Fanning  TG, Janczewski  TA, Taubenberger  JK. Characterization of the 1918 "Spanish" influenza virus neuraminidase gene. Proc Natl Acad Sci U S A. 2000;97:6785–90. DOIPubMed
  16. Reid  AH, Janczewski  TA, Lourens  RM, Elliot  AJ, Daniels  RS, Berry  CL, 1918 influenza pandemic caused by highly conserved viruses with two receptor-binding variants. Emerg Infect Dis. 2003;9:1249–53.PubMed
  17. Taubenberger  JK, Reid  AH, Lourens  RM, Wang  R, Jin  G, Fanning  TG. Characterization of the 1918 influenza virus polymerase genes. Nature. 2005;437:889–93. DOIPubMed
  18. Reid  AH, Taubenberger  JK. The 1918 flu and other influenza pandemics: "over there" and back again. Lab Invest. 1999;79:95–101.PubMed
  19. Reid  AH, Taubenberger  JK, Fanning  TG. Evidence of an absence: the genetic origins of the 1918 pandemic influenza virus. Nat Rev Microbiol. 2004;2:909–14. DOIPubMed
  20. Taubenberger  JK, Reid  AH, Fanning  TG. The 1918 influenza virus: a killer comes into view. Virology. 2000;274:241–5. DOIPubMed
  21. Jordan  E. Epidemic influenza: a survey. Chicago: American Medical Association, 1927.
  22. Capps  J, Moody  A. The recent epidemic of grip. JAMA. 1916;67:1349–50.
  23. Oxford  JS, Sefton  A, Jackson  R, Innes  W, Daniels  RS, Johnson  NP. World War I may have allowed the emergence of "Spanish" influenza. Lancet Infect Dis. 2002;2:111–4. DOIPubMed
  24. Fanning  TG, Slemons  RD, Reid  AH, Janczewski  TA, Dean  J, Taubenberger  JK. 1917 avian influenza virus sequences suggest that the 1918 pandemic virus did not acquire its hemagglutinin directly from birds. J Virol. 2002;76:7860–2. DOIPubMed
  25. Reid  AH, Fanning  TG, Slemons  RD, Janczewski  TA, Dean  J, Taubenberger  JK. Relationship of pre-1918 avian influenza HA and NP sequences to subsequent avian influenza strains. Avian Dis. 2003;47:921–5. DOIPubMed
  26. Bean  W, Schell  M, Katz  J, Kawaoka  Y, Naeve  C, Gorman  O, Evolution of the H3 influenza virus hemagglutinin from human and nonhuman hosts. J Virol. 1992;66:1129–38.PubMed
  27. Weis  W, Brown  JH, Cusack  S, Paulson  JC, Skehel  JJ, Wiley  DC. Structure of the influenza virus haemagglutinin complexed with its receptor, sialic acid. Nature. 1988;333:426–31. DOIPubMed
  28. Gambaryan  AS, Tuzikov  AB, Piskarev  VE, Yamnikova  SS, Lvov  DK, Robertson  JS, Specification of receptor-binding phenotypes of influenza virus isolates from different hosts using synthetic sialylglycopolymers: non-egg-adapted human H1 and H3 influenza A and influenza B viruses share a common high binding affinity for 6′-sialyl(N-acetyllactosamine). Virology. 1997;232:345–50. DOIPubMed
  29. Matrosovich  M, Gambaryan  A, Teneberg  S, Piskarev  VE, Yamnikova  SS, Lvov  DK, Avian influenza A viruses differ from human viruses by recognition of sialyloigosaccharides and gangliosides and by a higher conservation of the HA receptor-binding site. Virology. 1997;233:224–34. DOIPubMed
  30. Glaser  L, Stevens  J, Zamarin  D, Wilson  IA, Garcia-Sastre  A, Tumpey  TM, A single amino acid substitution in the 1918 influenza virus hemagglutinin changes the receptor binding specificity. J Virol. 2005;79:11533–6. DOIPubMed
  31. Kobasa  D, Takada  A, Shinya  K, Hatta  M, Halfmann  P, Theriault  S, Enhanced virulence of influenza A viruses with the haemagglutinin of the 1918 pandemic virus. Nature. 2004;431:703–7. DOIPubMed
  32. Kash  JC, Basler  CF, Garcia-Sastre  A, Carter  V, Billharz  R, Swayne  DE, Global host immune response: pathogenesis and transcriptional profiling of type A influenza viruses expressing the hemagglutinin and neuraminidase genes from the 1918 pandemic virus. J Virol. 2004;78:9499–511. DOIPubMed
  33. Grove  RD, Hetzel  AM. Vital statistics rates in the United States: 1940–1960. Washington: US Government Printing Office, 1968.
  34. Linder  FE, Grove  RD. Vital statistics rates in the United States: 1900–1940. Washington: US Government Printing Office, 1943.
  35. Simonsen  L, Clarke  MJ, Schonberger  LB, Arden  NH, Cox  NJ, Fukuda  K. Pandemic versus epidemic influenza mortality: a pattern of changing age distribution. J Infect Dis. 1998;178:53–60.PubMed
  36. Frost  WH. The epidemiology of influenza. Public Health Rep. 1919;34:1823–61. DOIPubMed
  37. Collins  SD. Age and sex incidence of influenza and pneumonia morbidity and mortality in the epidemic of 1928-1929 with comparative data for the epidemic of 1918–1919. Public Health Rep. 1931;46:1909–37. DOIPubMed
  38. Majde  JA. Influenza: Learn from the past. ASM News. 1996;62:514.
  39. Peiris  JS, Yu  WC, Leung  CW, Cheung  CY, Ng  WF, Nicholls  JM, Re-emergence of fatal human influenza A subtype H5N1 disease. Lancet. 2004;363:617–9. DOIPubMed

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