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Volume 12, Number 1—January 2006


Ocular Vaccinia Infection in Laboratory Worker, Philadelphia, 2004

Felicia M.T. Lewis*†Comments to Author , Esther Chernak*, Erinn Goldman†, Yu Li†, Kevin Karem†, Inger K. Damon†, Richard Henkel†, E. Claire Newbern*, Patrina Ross*, and Caroline C. Johnson*
Author affiliations: *Philadelphia Department of Public Health, Philadelphia, Pennsylvania, USA; †Centers for Disease Control and Prevention, Atlanta, Georgia, USA

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Vaccination status and serologic evidence of vaccinia immunity of patient and contacts

Patient and contact Prior vaccination Date of last vaccination Anti-orthopoxvirus IgG present* (acute-phase serum, 10/04; convalescent-phase serum, 12/04) Anti-orthopoxvirus IgM present† (acute-phase serum 10/04; convalescent-phase serum, 12/04)
Patient No –/Yes –/Yes
Home No No/no No/no
Worker 1 Yes, 5ׇ 1994 Yes/yes No/no
Worker 2§ Yes, as child 12/01/04 Yes/yes No/no
Worker 3§ Yes, as child 12/01/04 Yes/yes No/no
Worker 4§ Yes, as child 12/01/04 No/no No/no
Worker 5 No No/no No/no
Worker 6 No No/no No/no
Worker 7 No No/no No/no
Worker 8 No No/no No/no
Worker 9 No No/no No/no
Worker 10 No No/no No/no
Worker 11 No No/no No/no

*Immunoglobulin G (IgG) optical density cutoff value (COV) = 0.214408; –, not performed.
†IgM optical density COV = 0.015763.
‡The last vaccination was ≈10 years before this incident.
§Three laboratory workers who also manipulated vaccinia were vaccinated 1 week before the convalescent-phase blood sample was drawn (workers 2, 3, and 4). All 3 had been vaccinated as children; workers 2 and 3 had orthopoxvirus-reactive IgG levels present above the COV. Worker 4 did not have IgG levels above the COV either before or after her recent vaccination.

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