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Volume 12, Number 1—January 2006

Ocular Vaccinia Infection in Laboratory Worker, Philadelphia, 2004

Felicia M.T. Lewis*†Comments to Author , Esther Chernak*, Erinn Goldman†, Yu Li†, Kevin Karem†, Inger K. Damon†, Richard Henkel†, E. Claire Newbern*, Patrina Ross*, and Caroline C. Johnson*
Author affiliations: *Philadelphia Department of Public Health, Philadelphia, Pennsylvania, USA; †Centers for Disease Control and Prevention, Atlanta, Georgia, USA

Main Article


Vaccination status and serologic evidence of vaccinia immunity of patient and contacts

Patient and contact Prior vaccination Date of last vaccination Anti-orthopoxvirus IgG present* (acute-phase serum, 10/04; convalescent-phase serum, 12/04) Anti-orthopoxvirus IgM present† (acute-phase serum 10/04; convalescent-phase serum, 12/04)
Patient No –/Yes –/Yes
Home No No/no No/no
Worker 1 Yes, 5ׇ 1994 Yes/yes No/no
Worker 2§ Yes, as child 12/01/04 Yes/yes No/no
Worker 3§ Yes, as child 12/01/04 Yes/yes No/no
Worker 4§ Yes, as child 12/01/04 No/no No/no
Worker 5 No No/no No/no
Worker 6 No No/no No/no
Worker 7 No No/no No/no
Worker 8 No No/no No/no
Worker 9 No No/no No/no
Worker 10 No No/no No/no
Worker 11 No No/no No/no

*Immunoglobulin G (IgG) optical density cutoff value (COV) = 0.214408; –, not performed.
†IgM optical density COV = 0.015763.
‡The last vaccination was ≈10 years before this incident.
§Three laboratory workers who also manipulated vaccinia were vaccinated 1 week before the convalescent-phase blood sample was drawn (workers 2, 3, and 4). All 3 had been vaccinated as children; workers 2 and 3 had orthopoxvirus-reactive IgG levels present above the COV. Worker 4 did not have IgG levels above the COV either before or after her recent vaccination.

Main Article

Page created: February 16, 2012
Page updated: February 16, 2012
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