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Volume 12, Number 1—January 2006
THEME ISSUE
Influenza
Pathogenesis

Cell-mediated Protection in Influenza Infection

Paul G. Thomas*, Rachael Keating*, Diane J. Hulse-Post*, and Peter C. Doherty*Comments to Author 
Author affiliations: *St. Jude Children's Research Hospital, Memphis, Tennessee, USA

Main Article

Table

Conservation of human NP and M1 epitopes between H1N1 PR8 and 3 human isolates of H5N1 viruses (A/Hong Kong/156/1997, A/Hong Kong/213/2003, and A/Vietnam/1203/2004)*

Epitope HLA restriction PR8 sequence Conservation
NP 383–391 B*2705 SRYWAIRTR 3/3 identical
NP 418–426 B*3501 LPFDRTTIM 0/3 identical
NP 44–52 A*01 CTELKLSDY 2/3 identical (156 Y9Q)
NP 265–273 A*03 ILRGSVAHK 3/3 identical
NP 188–198 A*1101 TMVMELVRMIK 3/3 V7I mutation
NP 380–388 B*08 ELRSRYWAI 3/3 identical
NP 174–184 B*2705 RRSGAAGAAVK 2/3 identical (156 V10I)
M1 58–66 A*0201 GILGFVFTL 3/3 identical
M1 27–35 A*03 RLEDVFAGK 2/3 mutated (1203, 213 both R1K)
M1 13–21 A*1101 SIIPSGPLK 3/3 identical

*All 3 isolates were compared to the mouse-adapted PR8 strain and differences are reported. Sequences obtained from the Influenza Sequence Database (55). NP, nucleoprotein; HLA, human leukocyte antigen.

Main Article

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