Volume 12, Number 3—March 2006
Dispatch
Protease-resistant Prion Protein in Lymphoreticular Tumors of Variant Creutzfeldt-Jakob Disease Mice
Larisa Cervenakova*
, Oksana Yakovleva*, and Carroll McKenzie*
, Oksana Yakovleva*, and Carroll McKenzie*
Table
Demonstration of protease-resistant prion protein (PrPres) in the brain and lymphoreticular tissues of SJL/Ola mice infected with the agent of variant Creutzfeldt-Jakob disease (vCJD)
| Experimental group | Postinfection interval (d) | Western blot (PrPres)* |
||
|---|---|---|---|---|
| Brain | Lymphoreticular tissue |
|||
| Spleen | Lymph node | |||
| Mice infected with vCJD agent | ||||
| 1* | 199 | + | + | +† |
| 2* | 199 | + | + | +† |
| 3 | 222 | + | + | Not done |
| 4* | 318 | + | + | + |
| 5 | 318 | + | + | Not done |
| 6 | 318 | + | + | Not done |
| 7 | 342 | + | + | Not done |
| 8* | 343 | + | + | + |
| 9 | 382 | + | + | Not done |
| 10 | 386 | + | + | Not done |
| Control mice injected with 0.9% NaCl | ||||
| 1 | 405 | – | – | Not done |
| 2 | 405 | – | – | Not done |
| 3* | 321 | – | – | – |
| 4 | 405 | – | – | Not done |
*Widespread tumors of lymphoreticular tissue developed.
†Mouse also had PrPres in tumor involving thymus.
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