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Volume 12, Number 4—April 2006
Research

1951 Influenza Epidemic, England and Wales, Canada, and the United States

Cécile Viboud*Comments to Author , Theresa Tam†, Douglas Fleming‡, Mark A Miller*, and Lone Simonsen*
Author affiliations: *National Institutes of Health, Bethesda, Maryland, USA; †Public Health Agency of Canada, Ottawa, Ontario, Canada; ‡Royal College of General Practitioners, Harborne, Birmingham, United Kingdom

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Figure 2

Time series of monthly mortality from pneumonia and influenza (P&I, represented as death rate/100,000) from 1950 to 1972 in A) Canada and B) England and Wales. Black line: observed deaths, Red line: baseline deaths predicted by a seasonal regression model. Note the 2 arrows for the 1968 pandemic in England, representing the 2 waves of the smoldering A/H3N2 pandemic (1968–69 and 1969–70, respectively) (18).

Figure 2. Time series of monthly mortality from pneumonia and influenza (P&I, represented as death rate/100,000) from 1950 to 1972 in A) Canada and B) England and Wales. Black line: observed deaths, Red line: baseline deaths predicted by a seasonal regression model. Note the 2 arrows for the 1968 pandemic in England, representing the 2 waves of the smoldering A/H3N2 pandemic (1968–69 and 1969–70, respectively) (18).

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References
  1. Simonsen  L, Clarke  MJ, Schonberger  LB, Arden  NH, Cox  NJ, Fukuda  K. Pandemic versus epidemic influenza mortality: a pattern of changing age distribution. J Infect Dis. 1998;178:5360.PubMedGoogle Scholar
  2. Simonsen  L, Clarke  MJ, Williamson  GD, Stroup  DF, Arden  NH, Schonberger  LB. The impact of influenza epidemics on mortality: introducing a severity index. Am J Public Health. 1997;87:194450. DOIPubMedGoogle Scholar
  3. Simonsen  L, Reichert  TA, Viboud  C, Blackwelder  WC, Taylor  RJ, Miller  MA. Impact of influenza vaccination on seasonal mortality in the US elderly population. Arch Intern Med. 2005;165:26572. DOIPubMedGoogle Scholar
  4. Burnet  M. The influenza virus. Sci Am. 1953;188:2831. DOIGoogle Scholar
  5. Semple  AB, Davies  JB, Disley  PJ. Influenza in Liverpool. Lancet. 1958;1:957. DOIPubMedGoogle Scholar
  6. Great Britain, General Register Office. Annual summary of marriages, births, and deaths, in England and Wales. London: the Stationery Office (HSMO); 1958.
  7. National Statistics. UK. [cited 2004 Nov]. Available from http://www.statistics.gov.uk/StatBase/Product.asp?vlnk=1253&More=Y
  8. Collins  S, Lehmann  J. Trends and epidemics of influenza and pneumonia, 1918–1951. Public Health Rep. 1951;46:1487517. DOIPubMedGoogle Scholar
  9. Serfling  RE, Sherman  IL, Houseworth  WJ. Excess pneumonia-influenza mortality by age and sex in three major influenza A2 epidemics, United States, 1957-58, 1960 and 1963. Am J Epidemiol. 1967;86:43341.PubMedGoogle Scholar
  10. Housworth  WJ, Spoon  MM. The age distribution of excess mortality during A2 Hong Kong influenza epidemics compared with earlier A2 outbreaks. Am J Epidemiol. 1971;94:34850.PubMedGoogle Scholar
  11. Noble  G. Epidemiological and clinical aspects of influenza. In: Bear A, editor. Basic and applied influenza research. Boca Raton (FL): CRC Press; 1982.
  12. Bradley  WH, Massey  A, Logan  WP, Semple  AB, Benjamin  B, Grist  NR, Discussion: influenza 1951. Proc R Soc Med. 1951;44:789801.PubMedGoogle Scholar
  13. Canada, Dominion Bureau of Statistics. Influenza in Canada: some statistics on its characteristics and trends. Ottawa: The Bureau; 1958. p. 1–23.
  14. Freyche  M, Klimt  C. World incidence of influenza, 1950–1951. World Health Org. Epidemiological and Vital Statistics Report. 1951;5:14161.
  15. Jordan  EO. Epidemic influenza. Chicago: American Medical Association; 1927.
  16. Serfling  R. Methods for current statistical analysis of excess pneumonia-influenza deaths. Public Health Rep. 1963;78:494506. DOIPubMedGoogle Scholar
  17. Viboud  C, Grais  RF, Lafont  BA, Miller  MA, Simonsen  L. Multinational impact of the 1968 Hong Kong influenza pandemic: evidence for a smoldering pandemic. J Infect Dis. 2005;192:23348. DOIPubMedGoogle Scholar
  18. Nagler  FP, Burr  MM, Gillen  AL. The influenza virus epidemic in Canada during January-February, 1951. Can J Public Health. 1951;42:36774.PubMedGoogle Scholar
  19. Langmuir  AD, Housworth  J. A critical evaluation of influenza surveillance. Bull World Health Organ. 1969;41:3938.PubMedGoogle Scholar
  20. Assaad  F, Cockburn  WC, Sundaresan  TK. Use of excess mortality from respiratory diseases in the study of influenza. Bull World Health Organ. 1973;49:21933.PubMedGoogle Scholar
  21. World Health Organization. Mortality at ages 65 and older—United States, Canada, and Western Europe. Stat Bull Metrop Life Insur Co. 1971;52:811.
  22. Simonsen  L. The global impact of influenza on morbidity and mortality. Vaccine. 1999;17(Suppl 1):S310. DOIPubMedGoogle Scholar
  23. Fleming  DM, Cross  KW, Pannell  RS. Influenza and its relationship to circulatory disorders. Epidemiol Infect. 2005;133:25562. DOIPubMedGoogle Scholar
  24. Reichert  TA, Simonsen  L, Sharma  A, Pardo  SA, Fedson  DS, Miller  MA. Influenza and the winter increase in mortality in the United States, 1959-1999. Am J Epidemiol. 2004;160:492502. DOIPubMedGoogle Scholar
  25. Mills  CE, Robins  JM, Lipsitch  M. Transmissibility of 1918 pandemic influenza. Nature. 2004;432:9046. DOIPubMedGoogle Scholar
  26. Isaacs  A, Gledhill  AW, Andrewes  CH. Influenza A viruses; laboratory studies, with special reference to European outbreak of 1950–1. Bull World Health Organ. 1952;6:287315.PubMedGoogle Scholar
  27. Reid  AH, Taubenberger  JK, Fanning  TG. Evidence of an absence: the genetic origins of the 1918 pandemic influenza virus. Nat Rev Microbiol. 2004;2:90914. DOIPubMedGoogle Scholar
  28. Kilbourne  ED, Smith  C, Brett  I, Pokorny  BA, Johansson  B, Cox  N. The total influenza vaccine failure of 1947 revisited: major intrasubtypic antigenic change can explain failure of vaccine in a post-World War II epidemic. Proc Natl Acad Sci U S A. 2002;99:1074852. DOIPubMedGoogle Scholar
  29. Isaacs  A, Andrewes  CH. The spread of influenza; evidence from 1950-1951. BMJ. 1951;4737:9217. DOIPubMedGoogle Scholar
  30. Palese  P. Influenza: old and new threats. Nat Med. 2004;10:S827. DOIPubMedGoogle Scholar
  31. Nicholson  K, Hay  A. Textbook of influenza. Oxford: Blackwell; 1998.
  32. Lui  KJ, Kendal  AP. Impact of influenza epidemics on mortality in the United States from October 1972 to May 1985. Am J Public Health. 1987;77:7126. DOIPubMedGoogle Scholar
  33. Viboud  C, Boelle  PY, Pakdaman  K, Carrat  F, Valleron  AJ, Flahault  A. Influenza epidemics in the United States, France, and Australia, 1972–1997. Emerg Infect Dis. 2004;10:329.PubMedGoogle Scholar
  34. Simonsen  L, Olson  D, Viboud  C, Miller  M. Pandemic influenza and mortality: past evidence and projections for the future. In: Knobler S, Oberholtzer K, eds. Forum on microbial threats. Pandemic influenza: assessing capabilities for prevention and response. Washington: Institute of Medicine; 2004. p. 109–14.
  35. Holmes  EC, Taubenberger  JK, Grenfell  BT. Heading off an influenza pandemic. Science. 2005;309:989. DOIPubMedGoogle Scholar
  36. US Department of Health and Human Services. Pandemic influenza response and preparedness plan. [Accessed 2004 Mar 22]. Available from http://www.hhs.gov/nvpo/pandemicplan
  37. Simonsen  L, Reichert  TA, Miller  M. The virtues of antigenic sin: consequences of pandemic recycling on influenza-associated mortality. In: Options for the control of influenza V, International Congress Series 1263. Okinawa, Japan: Elsevier; 2003. p. 791–4.
  38. Olson  DR, Simonsen  L, Edelson  PJ, Morse  SS. Epidemiological evidence of an early wave of the 1918 influenza pandemic in New York City. Proc Natl Acad Sci U S A. 2005;102:1105963. DOIPubMedGoogle Scholar
  39. Influenza virus resource. [cited 2005 May 25]. Available from http://www.ncbi.nlm.nih.gov/genomes/FLU/FLU.html

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