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Volume 12, Number 5—May 2006
Research

Coronavirus HKU1 Infection in the United States

Frank Esper*, Carla Weibel†, David Ferguson†, Marie L. Landry†, and Jeffrey S. Kahn†Comments to Author 
Author affiliations: *Case Western Reserve University School of Medicine, Cleveland, Ohio, USA; †Yale University School of Medicine, New Haven, Connecticut, USA

Main Article

Table

Clinical manifestations associated with human coronavirus HKU1 infection*

Patient no. (sex) Age (mo) Specimen collection date Length of hospitalization (d) Diagnosis Underlying illness Signs/symptoms Chest radiographic findings
1 (M) 4 Dec 18 1 New onset seizures RAD Rhinorrhea, cough Not obtained
2 (M) 12 Dec 20 4 Pneumonia Cystic fibrosis Fever, rhinorrhea, cough, wheezing, rhonchi, retractions, rash Infiltrates
3 (F)†‡ 1 Dec 22, 31 9 Pneumonia None Fever, hypoxia, rhinorrhea, cough, wheezing, rhonchi, retractions, nasal flaring, apnea Hyperinflation, infiltrates, peribronchial cuffing, atelectasis
4 (M) 2 Jan 5 NH Fever None Fever, rhinorrhea Not obtained
5 (F)† 20 Jan 14, 16 2 ALTE None Fever, rhinorrhea, cough Infiltrates, atelectasis
6 (F) 3 Jan 16 NH Bronchiolitis Prematurity (34 weeks) Rhinorrhea, cough, wheezing, rhonchi Peribronchial cuffing
7 (M) 13 Jan 19 10 Hepatitis Biliary atresia, liver transplantation Rhinorrhea, rhonchi, abnormal LFT results Not obtained
8 (F) 16 Jan 19 1 Fever Sickle cell anemia Fever, rhinorrhea Not obtained
9 (F) 13 Feb 1 NH Fever None Fever, rhinorrhea, cough Not obtained

*M, male; F, female; RAD, reactive airway disease; NH, not hospitalized; ALTE, apparent life-threatening event; LFT, liver function tests (aspartate aminotransferase 238 U/mL, alanine aminotransferase 373 U/mL, alkaline phosphatase 406 U/mL, bilirubin [total/direct] 0.15/0.05 mg/dL).
†Two respiratory specimens tested positive for human coronavirus HKU1.
‡Patient required mechanical ventilation and admission to the pediatric intensive care unit.

Main Article

Page created: January 12, 2012
Page updated: January 12, 2012
Page reviewed: January 12, 2012
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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