Volume 12, Number 6—June 2006
Dispatch
Class 1 Integrons in Resistant Escherichia coli and Klebsiella spp., US Hospitals
Aarati N. Rao*1, Miriam Barlow*2, Leigh Ann Clark†, John R. Boring*, Fred C. Tenover†, and John E. McGowan*
Table 1
Crude association between nonsusceptibility to various antimicrobial drugs and positive test result for class 1 integron in Escherichia coli and Klebsiella spp. (Klebsiella pneumoniae and K. oxytoca)
| Class/agent | E. coli (n = 209), OR (95% CI)* | Klebsiella spp. (n = 111), OR (95% CI)* |
|---|---|---|
| Aminoglycosides | ||
| Amikacin | 3.15 (0.32–30.79) | 4.0 (0.86–18.51) |
| Gentamicin | 5.04 (2.69–9.47) | 4.49 (1.80–11.22) |
| Tobramycin | 5.55 (3.01–10.23) | 5.0 (2.0–12.52) |
| Fluoroquinolone | ||
| Ciprofloxacin | 3.00 (1.40–6.42) | 1.33 (0.59–3.04) |
| 3rd-generation cephalosporin | ||
| Cefotaxime | 1.14 (0.63–2.07) | 2.26 (0.99–5.19) |
| Cefpodoxime | 1.02 (0.59–1.75) | 2.61 (1.05–6.52) |
| Ceftazidime | 1.30 (0.73–2.31) | 2.54 (1.10–5.88) |
| 4th-generation cephalosporin | ||
| Cefepime | 0.35 (0.11–1.13) | 1.87 (0.57–6.10) |
| Monobactam | ||
| Aztreonam | 1.58 (0.87–2.89) | 1.10 (0.48–2.53) |
| β-Lactamase inhibitor | ||
| Piperacillin-tazobactam | 1.40 (0.75–2.62) | 1.82 (0.80–4.14) |
| Others | ||
| Chloramphenicol | 2.33 (1.30–4.17) | 2.29 (0.97–5.42) |
| Minocycline | 1.57 (0.90–2.76) | 1.20 (0.53–2.71) |
| Trimethoprim-sulfamethoxazole | 12.24 (6.28–23.86) | 3.68 (1.57–8.62) |
*OR, odds ratio; CI, confidence interval. Variables with p values £0.05, in boldface, are considered significant.
1Current affiliation: Midwestern University, Glendale, Arizona, USA
2Current affiliation: University of California at Merced, Merced, California, USA
Page created: January 04, 2012
Page updated: January 04, 2012
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