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Volume 12, Number 7—July 2006
Dispatch

Azithromycin Failure in Mycoplasma genitalium Urethritis

Catriona S. Bradshaw*†Comments to Author , Jorgen S. Jensen‡, Sepehr N. Tabrizi†§, Timothy R.H. Read*, Suzanne M. Garland*§, Carol A. Hopkins*, Lorna M. Moss*, and Christopher K. Fairley*†
Author affiliations: *Alfred Hospital, Victoria, Australia; †University of Melbourne, Victoria, Australia; ‡Statens Serum Institut, Copenhagen, Denmark; §Royal Women's Hospital, Victoria, Australia

Main Article

Table

Case-patients experiencing single-dose azithromycin treatment failure*

Patient†
TOC-1
TOC-2
TOC-3
TOC-4
Pretreatment PMN/HPF PMN/HPF Mg PCR Treatment-2 PMN/HPF Mg PCR Treatment-3 PMN/HPF Mg PCR Treatment-4 Mg PCR
1‡ >5 >5 Pos 1 g AZI >5 Pos 1 g AZI weekly, 3 doses <5 Pos MOX, 400 mg daily 10 d Neg
2‡ >5 <5 Pos 1 g AZI § Pos 1 g AZI weekly, 3 doses § Pos Moxifloxacin, 400 mg daily 10 d Neg
3 <5 § Pos 1 g AZI weekly 3 doses <5 Pos MOX, 400 mg daily 10 d § Neg
4ঠ>5 >5 Pos MOX, 400 mg daily 10 d Neg
5‡ >5 >5 Pos MOX, 400 mg daily 10 d Neg
6 <5 § Pos MOX, 400 mg daily 10 d Neg
7# >5 <5 Pos MOX, 400 mg daily 10 d Neg
8 >5 <5 Pos MOX, 400 mg daily 10 d Neg
9 >5 >5 Pos MOX, 400 mg daily 10 d Neg

*PMN/HPF, polymorphonuclear count per high power field (×1,000 magnification); Mg, Mycoplasma genitalium; PCR, polymerase chain reaction; Pos, positive; Neg, negative; AZI, azithromycin; MOX, moxifloxacin; d, days; bd, twice daily; tests of cure (TOCs) were performed 1 month after commencement of each therapy; TOC-1, first test of cure 1 month after treatment.
†All men treated with 1 g of azithromycin at first examination.
‡Patients with specimens cultured, MIC data available and presented for all 4 isolates.
§Urethral PMN count not available.
¶Patient 4 saw his general practitioner 3 weeks after receiving 1 g azithromycin with recurrent urethral discharge and dysuria and was retreated with 1 g azithromycin before his TOC-1.
#Only patient who was asymptomatic with persistent infection.

Main Article

Page created: December 19, 2011
Page updated: December 19, 2011
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