Volume 12, Number 7—July 2006
Dispatch
Transmission of New Bovine Prion to Mice
Thierry G.M. Baron*
, Anne-Gaëlle Biacabe*, Anna Bencsik*, and Jan P.M. Langeveld†
, Anne-Gaëlle Biacabe*, Anna Bencsik*, and Jan P.M. Langeveld†
Figure 2
Figure 2. Histopathologic analysis of brain of a C57BL/6 mouse infected with a type H isolate. A) Characteristic vacuolar lesions in the thalamus (hematoxylin and eosin stained, scale bar = 60 μm). B) Immunohistochemical analysis of prion protein with monoclonal antibody 12B2 (diluted 1:200) shows the absence of granular deposition, but the presence of plaques in the thalamus. The inset shows that plaques are amyloids since they bind Congo red and show birefringence in polarized light (scale bar = 60 μm, scale bar in inset = 16 μm).
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