Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link
Volume 12, Number 8—August 2006
Dispatch

Community-acquired Methicillin-resistant Staphylococcus aureus in Children, Taiwan

Wen-Tsung Lo*†, Wei-Jen Lin†, Min-Hua Tseng†, Sheng-Ru Wang†, Mong-Ling Chu†, and Chih-Chien Wang*†Comments to Author 
Author affiliations: *National Defense Medical Center, Taipei, Taiwan, Republic of China; †Tri-Service General Hospital, Taipei, Taiwan, Republic of China

Main Article

Table 2

Distribution of staphylococcal cassette chromosome (SCC)mec types and exotoxin patterns among methicillin-resistant Staphylococcus aureus (MRSA) strains collected from community-acquired (CA) MRSA infections and nares cultures*

CA-MRSA–colonizing strains
 CA-MRSA–infecting strains†
Characteristic PVL positive (n = 15) PVL negative (n = 74) (n = 32)
SCCmec type, no. (%) of isolates
II 0 1 (1.35) 0
III 0 1 (1.35) 0
IIIA 0 1 (1.35) 0
IV 7 (46.7) 70 (94.6)‡ 5 (15.6)
VT§ 8 (53.3) 1 (1.35)‡ 27 (84.4)
No. (%) of isolates positive for production of other toxins
ETA 0 2 (2.7) 0
ETB 1 (6.7) 2 (2.7) 0
TSST-1 0 5 (6.6) 1 (3.1)
SEA 1 (6.7) 6 (8.1) 0
SEB 14 (93.3) 57 (77.0)¶ 32 (100)
SEC 0 4 (5.4) 0
SED 0 0 0
SEE 0 1 (1.4) 0
SEG/SEI 0 30 (40.5)‡ 0
SEH 0 1 (1.4) 0

*PVL, Panton-Valentine leukocidin; ETA, exfoliative toxin A; ETB, exfoliative toxin B; TSST-1, toxic shock syndrome toxin-1; SEA, staphylococcal enterotoxin A; SEB, staphylococcal enterotoxin B; SEC, staphylococcal enterotoxin C; SED, staphylococcal enterotoxin D; SEE, staphylococcal enterotoxin E; SEG, staphylococcal enterotoxin G; SEI, staphylococcal enterotoxin I; SEH, staphylococcal enterotoxin H.
†All 32 CA-MRSA–infecting strains were PVL positive.
‡p<0.001 by χ2 test for PVL-positive MRSA-colonizing strains and CA-MRSA–infecting strains vs. PVL-negative MRSA-colonizing strains.
§VT refers to the SCCmec VT element in strain TSGH 17 from Taiwan (10).
¶p = 0.006 by χ2 test for PVL-positive MRSA-colonizing strains and CA-MRSA–infecting strains vs. PVL-negative MRSA-colonizing strains.

Main Article

References
  1. Prevost  G, Mourey  L, Colin  DA, Menestrina  G. Staphylococcal pore-forming toxins. Curr Top Microbiol Immunol. 2001;257:53–83.PubMedGoogle Scholar
  2. Lina  G, Piémont  Y, Godail-Gamot  F, Bes  M, Peter  MO, Gauduchon  V, Involvement of Panton-Valentine leukocidin-producing Staphylococcus aureus in primary skin infections and pneumonia. Clin Infect Dis. 1999;29:1128–32. DOIPubMedGoogle Scholar
  3. Vandenesch  F, Naimi  T, Enright  MC, Lina  G, Nimmo  GR, Heffernan  H, Community-acquired methicillin-resistant Staphylococcus aureus carrying Panton-Valentine leukocidin genes: worldwide emergence. Emerg Infect Dis. 2003;9:978–84.PubMedGoogle Scholar
  4. Wang  CC, Lo  WT, Chu  ML, Siu  LK. Epidemiological typing of community-acquired methicillin-resistant Staphylococcus aureus isolates from children in Taiwan. Clin Infect Dis. 2004;39:481–7. DOIPubMedGoogle Scholar
  5. Pan  ES, Diep  BA, Charlebois  ED, Auerswald  C, Carleton  HA, Sensabaugh  GF, Population dynamics of nasal strains of methicillin-resistant Staphylococcus aureus and their relation to community-associated disease activity. J Infect Dis. 2005;192:811–8. DOIPubMedGoogle Scholar
  6. Hussain  FM, Boyle-Vavra  S, Bethel  CD, Daum  RS. Current trends in community-acquired methicillin-resistant Staphylococcus aureus at a tertiary care pediatric facility. Pediatr Infect Dis J. 2000;19:1163–6. DOIPubMedGoogle Scholar
  7. National Committee for Clinical Laboratory Standards. Methods for disk diffusion: approved standard M2–A8: performance standards for antimicrobial disk susceptibility tests. Wayne (PA): The Committee; 2003.
  8. National Committee for Clinical Laboratory Standards. Performance standards for antimicrobial susceptibility testing: 14th informational supplement. NCCLS document M100–S14. Wayne (PA): The Committee; 2004.
  9. Oliveira  DC, de Lencastre  H. Multiplex PCR strategy for rapid identification of structural types and variants of the mec element in methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother. 2002;46:2155–61. DOIPubMedGoogle Scholar
  10. Boyle-Vavra  S, Ereshefsky  B, Wang  CC, Daum  RS. Successful multiresistant community-associated methicillin-resistant Staphylococcus aureus lineage from Taipei, Taiwan, that carries either the novel staphylococcal chromosome cassette mec (SCCmec) type VT or SCCmec type IV. J Clin Microbiol. 2005;43:4719–30. DOIPubMedGoogle Scholar
  11. Jarraud  S, Cozon  G, Vandenesch  F, Bes  M, Etienne  J, Lina  G. Involvement of enterotoxins G and I in staphylococcal toxic shock syndrome and staphylococcal scarlet fever. J Clin Microbiol. 1999;37:2446–9.PubMedGoogle Scholar
  12. McDougal  LK, Steward  CD, Killgore  GE, Chaitram  JM, McAllister  SK, Tenover  FC. Pulsed-field gel electrophoresis typing of oxacillin-resistant Staphylococcus aureus isolates from the United States: establishing a national database. J Clin Microbiol. 2003;41:5113–20. DOIPubMedGoogle Scholar
  13. Prevost  G, Couppie  P, Prevost  P, Gayet  S, Petiau  P, Cribier  B, Epidemiological data on Staphylococcus aureus strains producing synergohymenotropic toxins. J Med Microbiol. 1995;42:237–45. DOIPubMedGoogle Scholar
  14. Holmes  A, Ganner  M, McGuane  S, Pitt  TL, Cookson  BD, Kearns  AM. Staphylococcus aureus isolates carrying Panton-Valentine leukocidin genes in England and Wales: frequency, characterization, and association with clinical disease. J Clin Microbiol. 2005;43:2384–90. DOIPubMedGoogle Scholar
  15. Yamasaki  O, Kaneko  J, Morizane  S, Akiyama  H, Arata  J, Narita  S, The association between Staphylococcus aureus strains carrying Panton-Valentine leukocidin genes and the development of deep-seated follicular infection. Clin Infect Dis. 2005;40:381–5. DOIPubMedGoogle Scholar

Main Article

Page created: December 09, 2011
Page updated: December 09, 2011
Page reviewed: December 09, 2011
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
file_external