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Volume 12, Number 9—September 2006
Dispatch

Hepatitis C Virus Genotype 4 in Ugandan Children and Their Mothers

Robert J. Biggar*Comments to Author , Betty A. Ortiz-Conde†, Rachel K. Bagni†, Paul M. Bakaki‡, Cheng-Dian Wang†, Eric A. Engels*, Sam M. Mbulaiteye*, and Christopher M. Ndugwa‡
Author affiliations: *National Cancer Institute, Bethesda, Maryland, USA; †National Cancer Institute–Frederick, Frederick, Maryland, USA; ‡Makerere University Medical School and Mulago Hospital, Kampala, Uganda

Main Article

Figure 1

Estimated phylogenies of hepatitis C virus genotype 4; NS5B phylogenetic analysis based on 350 bp of NS5B nucleotide sequence. Ugandan sequences determined in this study are highlighted in black. Numerical values (presented when >60%) represent the statistical support for the tree topology as determined by 1,000 bootstrap replicates. Reference sequences for genotypes 1–3, 5, and 6 (7) were included in both analyses and retained as the outgroup. Accession numbers are provided in the text.

Figure 1. Estimated phylogenies of hepatitis C virus genotype 4; NS5B phylogenetic analysis based on 350 bp of NS5B nucleotide sequence. Ugandan sequences determined in this study are highlighted in black. Numerical values (presented when >60%) represent the statistical support for the tree topology as determined by 1,000 bootstrap replicates. Reference sequences for genotypes 1–3, 5, and 6 (7) were included in both analyses and retained as the outgroup. Accession numbers are provided in the text.

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References
  1. Madhava  V, Burgess  C, Drucker  E. Epidemiology of chronic hepatitis C virus infection in sub-Saharan Africa. Lancet Infect Dis. 2002;2:293–302. DOIGoogle Scholar
  2. Callahan  JD, Constantine  NT, Kataaha  P, Zhang  X, Hyams  KC, Bansal  J. Second generation hepatitis C virus assays: performance when testing African sera. J Med Virol. 1993;41:35–8. DOIGoogle Scholar
  3. Tess  BH, Levin  A, Brubaker  G, Shao  J, Drummond  JE, Alter  HJ, Seroprevalence of HCV in the general population of northeast Tanzania. Am J Trop Med Hyg. 2000;62:138–41.
  4. Jackson  JB, Guay  L, Goldfarb  J, Olness  K, Ndugwa  C, Mmiro  F, Hepatitis C virus antibody in HIV-1 infected Ugandan mothers. Lancet. 1991;337:551. DOIGoogle Scholar
  5. Mbulaiteye  SM, Biggar  RJ, Bakaki  PM, Pfeiffer  R, Whitby  D, Ower  AM, Human herpesvirus 8 infection and transfusion history in children with sickle cell disease in Uganda. J Natl Cancer Inst. 2003;95:1330–5. DOIGoogle Scholar
  6. Enomoto  N, Takada  A, Nakao  T, Date  T. There are two major types of hepatitis C virus in Japan. Biochem Biophys Res Commun. 1990;170:1021–5. DOIGoogle Scholar
  7. Ray  SC, Arthur  RR, Carella  A, Bukh  J, Thomas  DL. Genetic epidemiology of hepatitis C virus throughout Egypt. J Infect Dis. 2000;182:698–707. DOIGoogle Scholar
  8. Oni  AO, Harrison  TJ. Genotypes of hepatitis C virus in Nigeria. J Med Virol. 1996;49:178–86. DOIGoogle Scholar
  9. Simonsen  L, Kane  A, Lloyd  J, Zaffran  M, Kane  M. Unsafe injections in the developing world and transmission of bloodborne pathogens: a review. Bull World Health Organ. 1999;77:789–800.
  10. Rall  CJN, Dienstage  JL. Epidemiology of hepatitis C virus infection. Semin Gastrointest Dis. 1995;6:3–12.
  11. Menendez  C, Sanchez-Tapias  JM, Kahigwa  E, Mshinda  H, Costa  J, Vidal  J, Prevalence and mother-to-infant transmission of hepatitis viruses B, C, and E in southern Tanzania. J Med Virol. 1999;58:215–20. DOIGoogle Scholar
  12. Salemi  M, Vandamme  AM. Hepatitis C virus evolutionary patterns studied through analysis of full-genome sequences. J Mol Evol. 2002;54:62–70. DOIGoogle Scholar
  13. Ndjomou  J, Pybus  OG, Matz  B. Phylogenetic analysis of hepatitis C virus isolates indicates a unique pattern of endemic infection in Cameroon. J Gen Virol. 2003;84:2333–41. DOIGoogle Scholar
  14. Medhat  A, Shehata  M, Magder  LS, Mikhail  NN, Abdel-Baki  L, Nefah  M, Hepatitis C in a community in Upper Egypt: risk factors for infection. Am J Trop Med Hyg. 2002;66:633–8.
  15. Al-Knawy  B, Okamoto  H, Ahmed El-Mekki  A, Elbagir Khalafalla  M, Al Wabel  A, Qazi  F, Distribution of hepatitis C genotype and co-infection rate with hepatitis G in Saudi Arabia. Hepatol Res. 2002;24:95. DOIGoogle Scholar

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