Volume 13, Number 11—November 2007
Dispatch
Primary versus Nonprimary Cytomegalovirus Infection during Pregnancy, Israel
Galia Rahav*1
, Rinat Gabbay*, Asher Ornoy*†, Svetlana Shechtman†, Judith Arnon†, and Orna Diav-Citrin†
, Rinat Gabbay*, Asher Ornoy*†, Svetlana Shechtman†, Judith Arnon†, and Orna Diav-Citrin†
Table 2
Characteristics of aborted fetuses and neonates with congenital CMV disease*
| Case no. | Maternal infection | Maternal symptoms | Week of infection | US | AF | Outcome, wk | Natal/abortion status | Follow-up, 2 y |
|---|---|---|---|---|---|---|---|---|
| 1 | Primary | Flu | <20 | IUGR microcephaly | + | Live born, 38 | Congenital disease | Sensorineural hearing loss, PMR |
| 2 | Primary | None | <18 | Hyperechoic bowel | ND | Abortion, 19 | Postmortem: disseminated CMV | |
| 3 | Primary | Fever | 7 | Hyperechoic bowel | + | Abortion, 23 | Postmortem: disseminated CMV | |
| 4 | Primary | Fever | 12 | None | + | Abortion, 24 | Postmortem: disseminated CMV | |
| 5 | Nonprimary (group 1) | None | Unclear | IUGR | ND | Live born, 38 | Brain calcifications | PMR |
| 6 | Nonprimary (group 1) | Flu | 22 | Tricuspid regurgitation | ND | Abortion, 33 | Postmortem: disseminated CMV | |
| 7 | Nonprimary (group 1) | Fever | 20 | IUGR pericardial fluid, brain calcifications | + | Abortion, 30 | Postmortem: disseminated CMV | |
| 8 | Nonprimary (group 1) | Flu | <20 | None | + | Live born, 40 | Congenital disease | PMR |
| 9 | Nonprimary (group 2) | Fever | 12 | ND | + | Abortion, 24 | Postmortem: disseminated CMV | |
| 10 | Nonprimary (group 2) | Flu | 4 | ND | ND | Live born, 38 | Congenital disease | Sensorineural hearing loss, PMR |
| 11 | Nonprimary (group 2) | None | 14 | Liver calcifications | + | Abortion, 24 | Postmortem: disseminated CMV |
*CMV, cytomegalovirus; US, ultrasonograph; AF, amniotic fluid; IUGR, intrauterine growth retardation; +, positive according to PCR, culture, or both; ND, not done; PMR, psychomotor retardation.
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