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Volume 13, Number 2—February 2007


Reduced Efficacy of Insecticide-treated Nets and Indoor Residual Spraying for Malaria Control in Pyrethroid Resistance Area, Benin

Raphael N’Guessan*, Vincent Corbel†, Martin Akogbéto‡§, and Mark RowlandComments to Author 
Author affiliations: *London School of Hygiene and Tropical Medicine, Cotonou, Benin, West Africa; †Institut de Recherche pour le Developpement, Montpellier, France; ‡University of Abomey-Calavi, Cotonou, Benin; §Centre de Recherche Entomologique, Cotonou, Benin¶London School of Hygiene and Tropical Medicine, London, United Kingdom;

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Table 6

Molecular and biochemical assays* conducted on samples of Anopheles gambiae from Malanville and Ladji compared with laboratory-susceptible (Kisumu) and pyrethroid-resistant kdr (Vkper) strains†

Populations or strainsNFrequency of kdr (%)Oxidase
nmol P450 U/mg†α-esterase μmol/min/mgβ-esterase
Kisumu4000.15 (± 0.020)‡0.11 (± 0.019)‡§0.12 (± 0.016)‡
Malanville4560.25 (± 0.018)§0.07 (± 0.017)‡0.04 (± 0.015)§
Ladji45830.27 (± 0.018)§0.18 (± 0.017)¶0.15 (± 0.014)‡¶
Vkper471000.13 (± 0.017)‡0.11 (± 0.017)§¶0.14 (± 0.014)¶

*Mean enzymatic activity ± SE (standard error).
In each column, values not sharing the same superscript are significantly different at the 5% level.

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