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Volume 14, Number 12—December 2008


Mycobacterium bovis Strains Causing Smear-Positive Human Tuberculosis, Southwest Ireland

Olabisi Ojo, Stella Sheehan, G. Daniel Corcoran, Melissa Okker, Karen Gover, Vladyslav Nikolayevsky, Timothy Brown, James Dale, Stephen V. Gordon1, Francis Drobniewski, and Michael B. PrenticeComments to Author 
Author affiliations: University College Cork, Cork, Ireland (O. Ojo, M.B. Prentice); Cork University Hospital, Cork (S. Sheehan, G.D. Corcoran, M.B. Prentice); Veterinary Laboratories Agency Weybridge, Surrey, UK (M. Okker, K. Gover, J. Dale, S.V. Gordon); Health Protection Agency Barts and the London School of Medicine, London, UK (V. Nikolayevsky, T. Brown, F. Drobniewski);

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Table 2

Molecular characteristics of strains and clinical and demographic parameters of 11 patients from whom Mycobacterium bovis was isolated, southwest Ireland, 1998–2006*

Study no. Spoligotype SpolDB4† Mbovis. org‡ Other name§ VNTR pattern¶ Patient data
Sex/ age, y Sample site Sputum smear
HB002 ■■□■■□■□□□□□■■■□■■■■■■■■■■■■■■■■■■■■■■□□□□□ ST683 SB0140 A1 4-11-4-7-5-
1-5-8-3-2 F/81 Sputum +
HB008 ■■□■■□■□□□□□■■■□■■■■■■■■■■■■■■■■■■■■■■□□□□□ ST683 SB0140 A1 3-10-4-5-5-
1-5-8-3-4 F/86 Sputum
HB010 ■■□■■□■□□□□□■■■□■■■■■■■■■■■■■■■■■■■■■■□□□□□ ST683 SB0140 A1 4-3-4-7-5-
1-5-8-3-4 F/33 Sputum +
HB011 ■■□■■□■□□□□□■■■□■■■■■■■■■■■■■■■■□■■■■■□□□□□ ST680 SB0139 NA 4-3-4-7-3-
1-5-8-3-4 F/29 Sputum +
HB012 ■■□■■□■□□□□□■■■□■■■■■■■■■■■■■■■■□■■■■■□□□□□ ST680 SB0139 NA 4-10-4-7-4-
1-5-8-3-4 M/62 Sputum +
HB006 ■■□■■□■□□□□□■■■□■■■■■■■■■■■■■■■■■■□■■■□□□□□ ND SB1186 NA 4-11-4-5-5-
2-5-9-4-4 M/60 Urine NA
HB007 ■■□■■□■□□□□□■■■□■■■■■■■■■■■■■■■■■■□□■■□□□□□ ND SB1047 NA 4-10-3-7-7-
2-4-x-4-2 F/74 Neck abscess NA
HB003 ■■□■■□■□□□□□■■■□■■■■■■■■■■■■■■■■□□■■■■□□□□□ ST679 SB0142 D1 3-11-4-7-5-
1-6-8-3-4 M/37 Spinal disc aspirate NA
HB009 ■■□■■□■□□□□□■■■□■■■■■■■■■■■■■■■■■■□■□■□□□□□ ND SB1187 NA 4-11-4-7-5-
2-5-10-4-4 F/80 Sputum +
HB001 ■■□■■■■■□■□■■■■□■■■■■■■■■■■■■■■■■■■■■■□□□□□ ST691 SB130 A2 2-11-3-7-5-
2-3-8-2-3 M/16 Sputum +
HB005 ■■□■■■■■□■□■■■■□■■■□□■■■■■■■■■■■■■■■■■□□□□□ ND SB1185 NA 4-10-1-4-5-
2-6-11-7-4 M/68 Testis biopsy sample NA

*VNTR, variable number tandem repeats; +, smear positive by auramine and Ziehl-Neelsen stains; −, smear negative by auramine and Ziehl-Neelsen stains; NA, not applicable; ND, not described; x, not determined.
†Spoligotype designation as described in the SpolDB4 database (
‡Spoligotype assignment as described in the database (
§Spoligotype assignment (11).
¶VNTR profile based on a 10-loci scheme for M. bovis strains from Ireland in this order: QUB1895, QUB11a, QUB11b, ETR-A, ETR-B, MIRU 24, MIRU 26, QUB 3232, QUB 3336, and QUB26 (8).

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1Current affiliation: University College Dublin, Dublin, Ireland.