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Volume 14, Number 8—August 2008

Pediatric Pneumonia Death Caused by Community-acquired Methicillin-Resistant Staphylococcus aureus, Japan

Takashi Ito*, Makiko Iijima*, Takayoshi Fukushima*, Masato Nonoyama*, Masahiro Ishii*, Tatiana Baranovich†, Taketo Otsuka†, Tomomi Takano†, and Tatsuo Yamamoto†
Author affiliations: *Kitasato University School of Medicine, Kanagawa, Japan; †Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan;

Main Article


Characteristics of PVL-positive MRSA strains reported in Japan since 2000*

Type, gene, or resistancePVL-positive MRSA
Present strain
Previous strains
NN32NN1NN12, NN31EB 00449DB 00319


LeukocidinslukS-PV, lukF-PV†+++++
lukE-lukD, lukM
Hemolysinshla, hlg, hld+++++
Staphylococcal enterotoxinssea+
tst, seb, sec, 
sed, see, seh, 
sej, sek, sep
Exfoliative toxinseta, etb, etd


icaA, sdrD, sdrE

icaD, cna,§
eno, fnbA,
fnbB, ebpS,clfA, clfB, fib, 
sdrC, bbp¶

Drug resistance and penicillinase plasmidAminoglycosidesGEN#
Penicillinase plasmid (kb)+ 

*PVL, Panton-Valentine leukocidin; MRSA, methicillin-resistant Staphylococcus aureus; SCCmec IVx, staphylococcal cassette chromosome mec type IV with unknown subtypes; +, positive; ­­–, negative; GEN, gentamicin; KAN, kanamycin; STR, streptomycin; ERY, erythromycin; CLI, clindamycin; TET, tetracycline.
†GenBank accession nos. for the PVL gene sequences from strains NN32 and NN1 are AB286959 and AB186917, respectively.
egc, enterotoxin gene cluster, including seg, sei, sem, sen, and seo genes.
§cna, gene encoding for collagen binding protein (adhesin).
bbp, gene encoding for bone sialoprotein binding protein (adhesin).
#Drug resistance encoded by a conjugative drug resistance plasmid (pGKT1) (8).
**Multidrug-resistant penicillinase plasmid encoding for resistance to GEN, KAN, STR, ERY, and CLI, in addition to penicillin resistance (9).

Main Article

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Main Article

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Page updated: July 12, 2010
Page reviewed: July 12, 2010
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