Volume 15, Number 4—April 2009
Research
Experimental Infection of Potential Reservoir Hosts with Venezuelan Equine Encephalitis Virus, Mexico
Eleanor R. Deardorff, Naomi L. Forrester, Amelia P. Travassos da Rosa, Jose G. Estrada-Franco, Roberto Navarro-Lopez, Robert B. Tesh, and Nikos Vasilakis
Table
Viremia in rodents that died 1–14 days after inoculation with 3.2 log10 PFU of Venezuelan equine encephalitis virus subtype IE strain MX01-22*
| Rodent genus | dpi† | Tissue virus content (log10 PFU/g)† |
|||||
|---|---|---|---|---|---|---|---|
| Brain | Heart | Spleen | Kidney | Liver | Lung | ||
| Oryzomys |
2 |
1.8 |
2.7 |
3.3 |
2.0 |
3.2 |
0 |
| Oligoryzomys | 4 | 0 | 0 | 4.0 | 0 | 0 | 0 |
| 6 |
0 |
0 |
3.4 |
0 |
0 |
0 |
|
| Baiomys | 6 | 3.2 | 5.0 | 5.0 | 4.7 | 4.9 | 3.9 |
| 7 | 4.6 | 3.2 | 4.2 | 0 | 4.3 | 4.3 | |
| 7 | 2.0 | 2.0 | 3.0 | 3.4 | 2.6 | 4.1 | |
| 8 | 5.0 | 3.0 | 5.7 | 5.0 | 1.9 | 5.0 | |
*Not shown are 3 Liomys salvini, 2 Oligoryzomys fulvescens, and 1 Sigmodon hispidus rodents. These animals died on days 5–10 postinoculation and showed no detectable virus in any organs tested. dpi, days postinoculation.
†Limit of detection was 1 plaque in150 μL homogenate. Tissue sample weight varied between 0.002 and 0.01 grams.
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