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Volume 15, Number 8—August 2009


National Outbreak of Acanthamoeba Keratitis Associated with Use of a Contact Lens Solution, United States

Jennifer R. VeraniComments to Author , Suchita A. Lorick, Jonathan S. Yoder, Michael J. Beach, Christopher R. Braden, Jacquelin M. Roberts, Craig S. Conover, Sue Chen, Kateesha A. McConnell, Douglas C. Chang, Benjamin J. Park, Dan B. Jones, Govinda S. Visvesvara, Sharon L. Roy, and for the Acanthamoeba Keratitis Investigation Team1
Author affiliations: Centers for Disease Control and Prevention, Atlanta, Georgia, USA (J.R. Verani, S.A. Lorick, J.S. Yoder, M.J. Beach, C.R. Braden, J.M. Roberts, D.C. Chang, B.J. Park, G.S. Visvesvara, S.L. Roy); Illinois Department of Public Health, Chicago, Illinois, USA (C.S. Conover); California Department of Public Health, Sacramento, California, USA (S. Chen); Florida Department of Health, Tallahassee, Florida, USA (K.A. McConnell); and Baylor College of Medicine, Houston, Texas, USA (D.B. Jones)

Main Article

Table 2

Multivariate analysis of demographic characteristics and exposures among 72 Acanthamoeba keratitis case-patients and 140 controls who used soft contact lenses, United States, 2005–2007*

Demographic characteristic or exposure†No. (%) case-patients, 
n = 72No. (%) controls, 
n = 140Adjusted matched OR (95% CI)‡
AMOCMP40 (55.6)15 (10.7)16.9 (4.8–59.5)
Ever top off or reuse old solution in case40 (57.1)30 (22.7)2.8 (1.2–6.8)
<5 y as contact lens wearer37 (51.4)32 (22.9)2.8 (1.0–7.6)

*OR, odds ratio; CI, confidence interval; AMOCMP, Advanced Medical Optics Complete MoisturePlus.
†During 1mo before symptom onset. Missing values excluded from analysis.
‡Adjusted for age and sex. p<0.05.

Main Article

1Other members of the Acanthamoeba Keratitis Investigation Team: Stephanie P. Johnston, Alexandre DaSilva, Yvonne Qvarnstrom, Rama R. Sriram, E. Danielle Rentz, Leslie B. Hausman, Shannon K. Cosgrove, Brandy L. Peterson, Nicholas P. DiMeo, Rebecca C. Greco-Kone, Angela J. Deokar, Susan Brim, Aaron S. Kusano, David E. Cheek, Sharlene Persaud, Felicia Chow (Centers for Disease Control and Prevention [CDC]); Ingrid Trevino, (CDC and Illinois Department of Public Health, Springfield, IL, USA); Gita G. Mirchandani (CDC and Maryland Department of Health and Mental Hygiene, Baltimore, MD, USA); Emily J. Luckman (Maryland Department of Health and Mental Hygiene); Stacy M. Holzbauer (CDC and Minnesota Department of Health, St. Paul, MN, USA); Zack Moore (CDC and North Carolina Department of Health and Human Services, Raleigh, NC, USA); Adam J. Langer, Mary T. Glenshaw (CDC and New Jersey Department of Health and Human Services, Trenton, NJ, USA); Michael Cooper (CDC and Ohio Department of Health, Columbus, OH, USA); Tai-Ho Chen (CDC and Pennsylvania Department of Health, Harrisburg, PA, USA); Kira A. Christian (CDC and South Carolina Department of Health and Environmental Control, Columbia, SC, USA); L. Rand Carpenter (CDC and Tennessee Department of Health, Nashville, TN, USA); Marion A. Kainer (Tennessee Department of Health); John R. Su (CDC and Texas Department of Health, Austin, TX, USA); Ami S. Patel (CDC and Virginia Department of Health, Richmond, VA, USA); Aron J. Hall (CDC and West Virginia Department of Health and Human Resources, Charleston, WV, USA); Charlotte E. Joslin (University of Illinois at Chicago); Kirk R. Wilhelmus (Baylor College of Medicine)