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Volume 16, Number 12—December 2010

Oseltamivir-Resistant Pandemic (H1N1) 2009 Virus, South Korea

Hwajung Yi, Joo-Yeon Lee, Eun-Hye Hong, Mi-Seon Kim, Donghyok Kwon, Jang-Hoon Choi, Woo-Young Choi, Ki-Soon Kim, Jong-Koo Lee, Hee-Bok Oh, and Chun KangComments to Author 
Author affiliations: Author affiliation: Korea Centers for Disease Control and Prevention, Seoul, South Korea

Main Article

Table 1

Characteristics of 10 patients infected with oseltamivir-resistant pandemic (H1N1) 2009 virus, South Korea, 2009

Patient Age, y/ sex Antiviral treatment and date Date of specimen collection Type of clinical specimen Underlying condition
A 5/M Oseltamivir, 30 mg 2×/d (Oct 29–Nov 4); 60 mg 2×/d (Nov 5–9) Nov 6 Nasopharyngeal swab Mitochondrial cytopathic changes (bedridden)
B 46/M Oseltamivir, 150 mg 2×/d (Nov 6–15); zanamivir, 10 mg 2×/d (Nov 16–26) Nov 18 Nasopharyngeal swab Leukemia
C 1/F Oseltamivir, 30 mg 2×/d (Nov 16–21); 60 mg 2×/d (Nov 22–Dec 8) Nov 21 and 22 Nasopharyngeal swab Brain damage (fatal)
D 2/M Oseltamivir, 90 mg 2×/d (Nov 26–30); 180 mg and amantadine, 65 mg 2×/d (Dec 2–7) Nov 22, Dec 2 Nasal suction None
E 3/F Oseltamivir, 30 mg 2×/d (Dec 1–5 and 7–11) Dec 1, 7, and 9 Oropharyngeal swab (Dec 1, 7); nasopharyngeal swab (Dec 9) Asthma
F 3/F Oseltamivir, 45 mg 2×/d (Dec 10–15); 75 mg 2×/d (Dec 16–20) Dec 18 Oropharyngeal swab Delayed development
G 1/F Oseltamivir, 30 mg 2×/d (Dec 1–5); peramivir, 75 mg 1×/day (Dec 12–18) Dec 1, 5, and 15 Nasal/oropharyngeal swab Myelodysplasia (fatal)
H 63/M Oseltamivir, 150 mg 2×/d (Dec 7–15); zanamivir, 10 mg 2×/d (Dec 16–20) Dec 16 Oropharyngeal swab Diabetes
I 58/M Oseltamivir, 150 mg 2×/d (Dec 16–18); peramivir, 600 mg 1×/d, amantadine, 100 mg 2×/d a day, ribavirin, 300 mg 1×/d (Dec 19–25); zanamivir, 10 mg 2×/d (Dec 26–2010 Jan 1) Dec 26 Nasopharyngeal swab Cancer
J 60/M Oseltamivir, 75 mg 2×/d (Nov 30–Dec 2) Dec 1 Viral RNA Diabetes, cardiac disorders (fatal)

Main Article

Page created: August 28, 2011
Page updated: August 28, 2011
Page reviewed: August 28, 2011
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