Volume 16, Number 9—September 2010
CME ACTIVITY - Research
Illicit Drug Use and Risk for USA300 Methicillin-Resistant Staphylococcus aureus Infections with Bacteremia
Table 4
Patient and infection characteristics for 300 veterans with Staphylococcus aureus bacteremia and association with USA300 MRSA at 4 Veterans Affairs medical centers, USA, 2004–2008*
Variable |
USA300 MRSA bacteremia,† n = 67 |
Bacteremia due to all other S. aureus,† n = 233 |
p value‡ |
---|---|---|---|
Patient characteristics | |||
Age, y, mean ± SD | 63 ± 12 | 69 ± 13 | 0.0004 |
Sex | |||
M | 65 (22) | 230 (78) | 0.31 |
F | 2 (40) | 3 (60) | |
Race | |||
Black | 34 (36) | 61 (64) | 0.0001 |
Other | 33 (16) | 172 (84) | |
Year of presentation§ | |||
Late | 45 (27) | 124 (73) | 0.04 |
Early | 22 (17) | 109 (83) | |
Charlson score, mean ± SD | 5.2 ± 3.6 | 4.6 ± 2.8 | 0.19 |
HIV infection | |||
Yes | 5 (31) | 11 (69) | 0.36 |
No | 62 (22) | 222 (78) | |
Illicit drug use | |||
Yes | 13 (59) | 9 (41) | <0.0001 |
No | 54 (19) | 224 (81) | |
History of colonization or infection with MRSA* | |||
Yes | 21 (26) | 59 (74) | 0.33 |
No | 46 (21) | 174 (79) | |
Hospitalized in year before infection | |||
Yes | 40 (21) | 155 (79) | 0.30 |
No | 27 (26) | 78 (74) | |
Surgery in year before infection | |||
Yes | 17 (16) | 92 (84) | 0.03 |
No | 50 (26) | 141 (74) | |
Residence in LTCF in year before infection | |||
Yes | 10 (29) | 24 (71) | 0.29 |
No | 57 (21) | 209 (79) | |
Renal failure in year before infection | |||
Yes | 42 (23) | 144 (77) | 0.90 |
No |
25 (22) |
89 (78) |
|
Infection characteristics | |||
Nosocomial infection | |||
Yes | 25 (15) | 147 (85) | 0.0002 |
No | 42 (33) | 86 (67) | |
Central line at time of infection | |||
Yes | 11 (13) | 72 (87) | 0.02 |
No | 56 (26) | 161 (74) | |
Permanent hardware at time of infection | |||
Yes | 20 (33) | 68 (77) | 0.92 |
No | 48 (28) | 126 (72) | |
Source of infection | |||
Primary | 19 (15) | 107 (85) | 0.01 |
Secondary | 48 (28) | 126 (72) | |
Infection complicated by endocarditis | |||
Yes | 9 (24) | 29 (76) | 0.83 |
No | 57 (22) | 201 (78) | |
Infection complicated by pneumonia | |||
Yes | 8 (18) | 37 (82) | 0.40 |
No | 57 (23) | 186 (77) |
*MRSA, methicillin-resistant S. aureus, LTCF, long-term care facility.
†Values are no. (%) except as indicated.
‡Calculated by using Pearson χ2 or Fisher exact tests for categorical variables, Student t test or Wilcoxon signed-rank test for continuous variables.
§Year of presentation stratified into 2 periods: early (January 1, 2004–March 31, 2006) and late (April 1, 2006–June 30, 2008).