Volume 16, Number 9—September 2010
Research
Comparison of Pandemic (H1N1) 2009 and Seasonal Influenza, Western Australia, 2009
Table
Parameter |
No. respondents |
Pandemic (H1N1) 2009, no. (%) |
Seasonal influenza, no. (%) |
RD |
Univariate χ2 p value |
OR† (95% CI) |
p value |
Symptoms | |||||||
Fever‡ | 1,159 | 762 (88) | 225 (78) | 10 | 0.001 | 1.64 (1.15–2.35) | 0.01§ |
Cough | 1,159 | 743 (85) | 236 (82) | 3 | NS | 1.45 (1.01–2.34) | 0.01§ |
Myalgia/arthalgia | 1,159 | 565 (65) | 173 (60) | 5 | NS | 1.40 (1.06–1.87) | 0.02§ |
Diarrhea | 1,159 | 165 (19) | 35 (12) | 7 | 0.008 | 1.72 (1.15–2.57) | 0.01§ |
Rhinorrhea | 1,159 | 494 (57) | 189 (66) | −9 | 0.007 | 0.60 (0.45–0.80) | 0.01§ |
Sore throat | 1,159 | 488 (56) | 169 (59) | −3 | NS | 0.82 (0.62–1.09) | 0.17 |
Shortness of breath | 1,159 | 289 (33) | 99 (35) | −2 | NS | 1.14 (0.85–1.53) | 0.38 |
Headache | 1,159 | 537 (62) | 176 (61) | 1 | NS | 1.02 (0.77–1.35) | 0.91 |
Vomiting or nausea | 1,159 | 284 (33) | 80 (28) | 5 | NS | 1.14 (0.84–1.54) | 0.40 |
Fatigue | 1,159 | 639 (73) | 205 (71) | 2 | NS | 1.12(0.83–1.51) | 0.47 |
Rigors | 1,159 | 471 (54) | 148 (52) | 2 | NS | 1.13 (0.86–1.48) | 0.40 |
ILI criteria met¶ |
1,159 |
706 (81 |
209 (73) |
8 |
0.002 |
1.50 (1.09–2.06) |
0.01§ |
Underlying medical conditions | |||||||
Diabetes | 1,032 | 49 (7) | 18 (6) | 1 | NS | 1.93 (1.07–3.51) | 0.03§ |
Heart disease | 1,027 | 34 (5) | 20 (7) | −2 | NS | 1.16 (0.63–2.16) | 0.63 |
Respiratory disease | 1,031 | 178 (24) | 62 (22) | 2 | NS | 1.33 (0.94–1.87) | 0.10 |
Renal disease | 1,028 | 13 (2) | 7 (2) | 0 | NS | 1.17 (0.44–3.10) | 0.76 |
Neurologic disease | 1,028 | 12 (2) | 7 (2) | 0 | NS | 0.91 (0.33–2.53) | 0.86 |
Hematologic disorder | 1,028 | 19 (3) | 5 (2) | 1 | NS | 2.33 (0.82–6.66) | 0.11 |
Metabolic disease (not diabetes) | 1,028 | 12 (2) | 4 (1) | 1 | NS | 1.25 (0.38–4.06) | 0.71 |
Immune impairment | 1,028 | 26 (3) | 16 (6) | −3 | NS | 0.88 (0.45–1.71) | 0.70 |
Morbid obesity | 1,031 | 64 (9) | 32 (11) | −2 | NS | 1.12 (0.70–1.80) | 0.64 |
Current smoker | 1,032 | 98 (13) | 35 (12) | 1 | NS | 1.36 (0.89–2.08) | 0.16 |
Pregnancy (women only) | 556 | 36 (9) | 8 (5) | 4 | NS | 1.85 (0.84–4.10) | 0.13 |
Any |
1,051 |
366 (48) |
135 (47) |
1 |
NS |
1.44 (1.07–1.94) |
0.02§ |
Medical care | |||||||
Hospitalization | 1,159 | 129 (15) | 36 (12) | 3 | NS | 1.58 (1.04–2.39) | 0.03§ |
Antiviral treatment | 1,103 | 388 (47) | 71 (26) | 21 | 0.001 | 3.12 (2.27–4.29) | 0.01§ |
*Totals respondents may not sum to 1,159 for all parameters because questions regarding underlying medical conditions and antiviral treatment were added shortly after the study was initiated, and there are intermittent missing values to individual questions for some respondents. RD, risk difference (absolute difference in the proportion of pandemic and seasonal influenza patients reporting a given parameter); OR, odds ratio; CI, confidence interval; NS, not significant; ILI, influenza–like illness (patient had fever and cough or sore throat).
†ORs were computed by using logistic regression to control for age. Each row depicts data from a separate regression equation, where the dependent variable was defined as influenza type and age (in years) and a single patient characteristic, as listed in the first column of the row (coded as a dichotomous variable indicating the presence or absence of the respective symptom or underlying medical condition) were included as the predictor variables. In all of the logistic analyses performed, age remained significantly associated with influenza type, i.e., younger patients had a higher odds of having pandemic influenza compared with seasonal influenza.
‡Fever was defined as temperature >38°C or subjective fever if temperature was not measured.
§Significant OR obtained using logistic regression.
¶ Patient reported >1 of the underlying medical conditions listed.