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Volume 16, Number 9—September 2010
Dispatch

Tuberculosis Acquired Outside of Households, Rural Vietnam

Tran N. Buu, Dick van Soolingen, Mai N.T. Huyen, Nguyen N.T. Lan, Hoang T. Quy, Edine W. Tiemersma, Martien W. Borgdorff, and Frank G.J. CobelensComments to Author 
Author affiliations: Author affiliations: Pham Ngoc Thach Tuberculosis and Lung Disease Hospital, Ho Chi Minh City, Vietnam (T.N. Buu, M.N.T. Huyen, N.N.T. Lan, H.T. Quy); National Institute of Public Health and the Environment, Bilthoven, the Netherlands (D. van Soolingen); KNCV Tuberculosis Foundation, The Hague, the Netherlands (E.W. Tiemersma); Academic Medical Centre, Amsterdam, the Netherlands (M.W. Borgdorff, F.G.J. Cobelens)

Main Article

Table

Characteristics of case-patients with exposure to tuberculosis within household, rural Vietnam, 2003–2006*

Patient no.
 Age, y/sex
 Previous treatment
 Relationship to index case-patient
 Genotype
Comparison of strain type with that of index case-patient
Index case-patient
 Household case-patient
 Spoligotype (no. different spacers)†
 RFLP
 VNTR‡
 Final classification
1 40/M No Brother Beijing EAI2-Manila Different (26) Different 12 Different
2 55/M No Brother NR Beijing Different (27) Different 10 Different
3 49/M No Brother EAI4-VNM EAI4-VNM Same (0) Different 4 Different
4 51/F No Spouse EAI4-VNM EAI4-VNM Same (0) ND 2 Different
5 48/M No Spouse Zero Zero Same (0) Same 0 Same
6 36/M No Brother Beijing Beijing Same (0) ND 1 Same
7 41/M No Grandson EAI5 EAI5 Same (1) ND 5 Different
8 41/M No Brother U EAI4-VNM Different (17) ND 2 Different
9 31/M No Brother EAI4-VNM NR Different (4) ND 4 Different
10 29/M No Brother EAI5 NR Different (5) ND 7 Different
11 72/M Yes Grandson EAI4-VNM Beijing Different (27) Different 13 Different
12 37/M No Son Beijing EAI5 Different (29) ND 7 Different
13 38/F No Spouse EAI4-VNM EAI2-NTB Different (16) Different 3 Different

*RFLP, restriction fragment-length polymorphism; VNTR, variable number of tandem repeats; EAI4-VNM: East African–Indian family, Vietnam genotype; NR, not represented in spoligotype database (10); ND, RFLP typing not done.
†Difference in the number of direct repeat spacers between the spoligotypes of the index case-patient and that of the household case-patients. Genotypes based on spoligotyping in accordance with classification by Brudey et al. (10).
‡No. loci with different alleles.

Main Article

References
  1. Wang  PD, Lin  RS. Tuberculosis transmission in the family. J Infect. 2000;41:249–51. DOIPubMedGoogle Scholar
  2. Verver  S, Warren  RM, Munch  Z, Richardson  M, van der Spuy  GD, Borgdorff  MW, Proportion of tuberculosis transmission that takes place in households in a high incidence area. Lancet. 2004;363:212–4. DOIPubMedGoogle Scholar
  3. Marais  BJ, Heseling  AC, Schaaf  HS, Gie  RP, van Helden  PD, Warren  RM. Mycobacterium tuberculosis transmission is not related to household genotype in a setting of high endemicity. J Clin Microbiol. 2009;47:1338–43. DOIPubMedGoogle Scholar
  4. The Socialist Republic of Vietnam. The third country report on following up the implementation to the declaration of commitment on HIV and AIDS. Hanoi (Vietnam): The Ministry of Health; 2008.
  5. Hoa  NB, Sy  DN, Nhung  NV, Tiemersma  EW, Borgdorff  MW, Cobelens  FGJ. A national survey of tuberculosis prevalence in Vietnam. Bull World Health Organ. 2010;88:273–80. DOIPubMedGoogle Scholar
  6. Buu  TN, Huyen  MN, Lan  NT, Quy  HT, Hen  NV, Zignol  M, The Beijing genotype is associated with young age and multidrug-resistant tuberculosis in rural Vietnam. Int J Tuberc Lung Dis. 2009;13:900–6.PubMedGoogle Scholar
  7. World Health Organization. Treatment of tuberculosis. Guidelines for national programmes, 3rd ed. WHO/CDS/TB/2003.313. Geneva: The Organization; 2003.
  8. Kamerbeek  J, Schouls  L, Kolk  A, van Agterveld  M, van Soolingen  D, Kuijper  S, Simultaneous detection and strain differentiation of Mycobacterium tuberculosis for diagnosis and epidemiology. J Clin Microbiol. 1997;35:907–14.PubMedGoogle Scholar
  9. Filliol  I, Driscoll  JR, van Soolingen  D, Kreiswirth  BN, Kremer  K, Valétudie  G, Snapshot of moving and expanding clones of Mycobacterium tuberculosis and their global distribution assessed by spoligotyping in an international study. J Clin Microbiol. 2003;41:1963–70. DOIPubMedGoogle Scholar
  10. Brudey  K, Driscoll  JR, Rigouts  L, Prodinger  WM, Gori  A, Al-Hajoj  SA, Mycobacterium tuberculosis complex genetic diversity: mining the fourth international spoligotyping database (SpolDB4) for classification, population genetics and epidemiology. BMC Microbiol. 2006;6:23. DOIPubMedGoogle Scholar
  11. Schaaf  HS, Michaelis  IA, Richardson  M, Booysen  CN, Gie  RP, Warren  R, Adult-to-child transmission of tuberculosis: household or community contact? Int J Tuberc Lung Dis. 2003;7:426–31.PubMedGoogle Scholar
  12. de Jong  BC, Hill  PC, Aiken  A, Awine  T, Antonio  M, Adetifa  IM, Progression to active tuberculosis, but not transmission, varies by Mycobacterium tuberculosis lineage in The Gambia. J Infect Dis. 2008;198:1037–43. DOIPubMedGoogle Scholar
  13. Behr  MA, Hopewell  PC, Paz  EA, Kawamura  LM, Schecter  GF, Small  PM. Predictive value of contact investigation for indentifying recent transmission of Mycobacterium tuberculosis. Am J Respir Crit Care Med. 1998;158:465–9.PubMedGoogle Scholar
  14. Crampin  AC, Glynn  JR, Traore  H, Yates  MD, Mwaungutu  L, Mwennebabu  M, Tuberculosis transmission attributable to close contacts and HIV status, Malawi. Emerg Infect Dis. 2006;12:729–35.PubMedGoogle Scholar

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