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Volume 17, Number 3—March 2011


Nontuberculous Mycobacteria in Respiratory Tract Infections, Eastern Asia

Sami SimonsComments to Author , Jakko van Ingen, Po-Ren Hsueh, Nguyen Van Hung, P.N. Richard Dekhuijzen, Martin J. Boeree, and Dick van Soolingen
Author affiliations: Author affiliations: Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands (S. Simons, J. van Ingen, P.N.R. Dekhuijzen, M.J. Boeree); National Institute for Public Health and the Environment (RIVM),; Bilthoven, the Netherlands (J. van Ingen, D. van Soolingen); National Taiwan University Hospital, Taipei, Taiwan (P.-R. Hsueh); National Hospital of Tuberculosis and Respiratory Diseases, Hanoi, Vietnam (N.V. Hung)

Main Article

Table 2

Clinical relevance of NTM species isolated from pulmonary samples collected in Asia, by country, 1971–2007*

Study area No. patients Patients for whom NTM infection was considered clinically relevant, % Criteria used (year of revision) Reference
Hong Kong 168 17 ATS criteria (1990) (6)
Japan 357 76† ATS criteria (1997) (16)
South Korea 794 17 ATS criteria (1997) (21)
South Korea 23 65‡ BTS criteria (1999) (23)
Singapore 23 65 Compatible signs and symptoms, >3 positive sputum specimens, and radiographic features of recent lung disease (25)
Taiwan 111 9 ATS criteria (1990) (28)
Taiwan 169 28§ NTM in >2 samples, new radiographic lesions ,and no other pathogens (definite) or other concomitant bacteria (probable NTM) found (29)
Thailand 33 76 NTM in sample(s); compatible signs, symptoms, and radiographic features; and no other explanation (30)
Thailand 24 29 Continued NTM isolation, progressive pulmonary disease, and worsening radiographic lesions (32)
Thailand 42 71 Repeated isolation of high numbers of NTM and presence of compatible disease process (33)

*NTM, nontuberculous mycobacterium; ATS, American Thoracic Society (1); BTS, British Thoracic Society.
†Only Mycobacterium avium complex bacteria were included in this study.
‡Only M. kansasii was included.
§14% if only definite NTM were included.

Main Article