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Volume 17, Number 3—March 2011
Letter

Mycobacterium mageritense Pulmonary Disease in Patient with Compromised Immune System

R. Gordon HuthComments to Author , Barbara A. Brown-Elliott, and Richard J. Wallace
Author affiliations: Author affiliations: University of Texas Southwestern Residency Programs, Austin, Texas, USA (R.G. Huth); University of Texas Health Science Center, Tyler, Texas, USA (B.A. Brown-Elliott, R.J. Wallace, Jr.)

Main Article

Table

In vitro activity of 23 isolates of Mycobacterium mageritense, United States, 2009*

Antimicrobial agent
No. isolates tested
MICs of current isolate, μg/mL
Intermediate breakpoint, μg/mL
MIC range, μg/mL
MIC50, μg/mL
MIC90, μg/mL
% S/I
Amikacin 23 8 32 <1–32 16 32 100
Cefoxitin 23 16 32–64 <8–256 32 64 91
Ciprofloxacin 23 0.25 2 <0.25–0.5 0.25 0.5 100
Clarithromycin† 23 8 4 1–>64 >32 >64 4
Doxycycline 22 1 2–8 0.25–>64 8 >32 50
Imipenem 22 4 8 <0.5–8 2 4 100
Linezolid 22 4 16 <2–16 4 8 100
Sulfamethoxazole 21 4 32 <2–32 8 32 100
Trimethoprim/sulfamethoxazole 6 1/19 2/38‡ <0.25/4.8– 2/38 0.5/9.5 2/38 100
Tobramycin 23 <2 8 2–64 >16 >32 30
Tigecycline 5 0.12 –§ <0.03–0.12 0.06 0.12 NA

*Includes 6 isolates previously reported (2). S, susceptible; I, intermediate; NA, not available.
†Three days’ incubation.
‡Proposed breakpoint (7).
§No Clinical and Laboratory Standards Institute breakpoints established for tigecycline.

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References
  1. Domenech  P, Jimenez  MS, Menendez  MC, Bull  TJ, Samper  S, Manrique  A, Mycobacterium mageritense sp. nov. Int J Syst Bacteriol. 1997;47:53540. DOIPubMed
  2. Wallace  RJ, Brown-Elliott  BA, Hall  L, Roberts  G, Wilson  RW, Mann  LB, Clinical and laboratory features of Mycobacterium mageritense. J Clin Microbiol. 2002;40:29305. DOIPubMed
  3. Appelgren  P, Farnebo  F, Dotevall  L, Studahl  M, Jönsson  B, Petrini  B. Late-onset posttraumatic skin and soft tissue infections caused by rapid-growing mycobacteria in tsunami survivors. Clin Infect Dis. 2008;47:e116. DOIPubMed
  4. Gira  AK, Reisenauer  AH, Hammock  L, Nadiminti  U, Macy  JT, Reeves  A, Furunculosis due to Mycobacterium mageritense associated with footbaths at a nail salon. J Clin Microbiol. 2004;42:18137. DOIPubMed
  5. Miki  M, Shimizukawa  M, Okayama  H, Kazumi  Y. Case of pulmonary Mycobacterium mageritense infection: the difficulty of differential diagnosis of granulomatous lung disease. Kekkaku. 2007;82:18994.PubMed
  6. Steingrube  VA, Gibson  JL, Brown  BA, Zhang  Y, Wilson  RW, Rajagopalan  M, PCR amplification and restriction endonuclease analysis of a 65-kiloDalton heat shock protein gene sequence for taxonomic separation of rapidly growing mycobacteria [ERRATUM 1995;33:1686]. J Clin Microbiol. 1995;33:14953.PubMed
  7. Woods  GL, Brown-Elliott  BA, Desmond  EP, Hall  GS, Heifets  L, Pfyffer  GE, Susceptibility testing of mycobacteria, nocardia, and other aerobic actinomycetes; approved standard. NCCLS Document M24-A. Wayne (PA): Clinical and Laboratory Standards Institute; 2003.
  8. Adékambi  T, Colson  P, Drancourt  M. rpoB-based identification of nonpigmented and late pigmented rapidly growing mycobacteria. J Clin Microbiol. 2003;41:5699708. DOIPubMed
  9. Griffith  DE, Aksamit  T, Brown-Elliott  BA, Catanzaro  A, Daley  C, Gordin  F, An official ATS/IDSA statement: diagnosis, treatment and prevention of nontuberculous mycobacterial diseases. Am J Respir Crit Care Med. 2007;175:367416. DOIPubMed
  10. Nash  KA, Andini  N, Zhang  Y, Brown-Elliott  BA, Wallace  RJ Jr. Intrinsic macrolide resistance in rapidly growing mycobacteria. Antimicrob Agents Chemother. 2006;50:34768. DOIPubMed

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