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Volume 17, Number 5—May 2011
Research

Plasmodium knowlesi Malaria in Children

Bridget E. BarberComments to Author , Timothy William, Mohammad Jikal, Jenarun Jilip, Prabakaran Dhararaj, Jayaram Menon, Tsin W. Yeo, and Nicholas M. Anstey
Author affiliations: Author affiliations: Menzies School of Health Research, Darwin, Northern Territory, Australia (B.E. Barber, T.W. Yeo, N.M. Anstey); Charles Darwin University, Darwin, Northern Territory (B.E. Barber, T.W. Yeo, N.M. Anstey); Queen Elizabeth Hospital, Kota Kinabalu, Sabah, Malaysia (B.E. Barber, T. William, J. Menon); Sabah Department of Health, Kota Kinabalu (T. William, M. Jikal, J. Jilip, J. Menon); Kudat District Hospital, Kudat, Sabah, Malaysia (P. Dhararaj); Royal Darwin Hospital, Darwin (T.W. Yeo, N.M. Anstey)

Main Article

Table 2

Malaria treatment according to Plasmodium species and response to treatment in children, Kudat, Malaysia, January 1–November 30, 2009*

Species and treatment regimen No. (%) patients Days until negative smear†
P. knowlesi, n = 16
3 days CQ/PQ 13 (81) 2 (2–3, 1–5)
Oral Q 2 (13) 2, 2
IV Q 1 (6) 2
All
2 (2–3, 1–5)
P. falciparum, n = 14
3 days CQ/PQ → oral Q 2 (14) 5, 5
Oral Q → AL 1 (7) 3
SP/PQ → AM 1 (7) 8
SP/PQ 2 (14) 1, 2
SP/PQ → CQ/Q → AL 1 (7) 3
SP/PQ → CQ/IV Q → AL 1 (7) 5
SP/PQ → CQ/IV Q → oral Q 1 (7) 3
SP/PQ → oral Q → IV Q → oral Q 1 (7) 16
IV Q → oral Q 2 (14) 1, 10
IV Q → oral Q/PQ 1 (7) 11
Oral Q/PQ → AM 1 (7) 10
All 5 (3–10, 1–16)‡

*IQR, interquartile range; CQ, chloroquine; PQ, primaquine; Q, quinine; IV, intravenous; AL, artemether/lumefantrine; SP, sulfamethoxazole/pyrimethamine; AM, artesunate/mefloquine.
†Values are mean (IQR, range) by category or days by patient.
‡p value = 0.009 for days until negative smear for P. falciparum vs. P. knowlesi.

Main Article

Page created: August 09, 2011
Page updated: August 09, 2011
Page reviewed: August 09, 2011
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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