Volume 17, Number 7—July 2011
Research
Severe Plasmodium knowlesi Malaria in a Tertiary Care Hospital, Sabah, Malaysia
Timothy William, Jayaram Menon, Giri S. Rajahram, Leslie Chan, Gordon Ma, Samantha Donaldson, Serena Khoo, Charlie Fredrick, Jenarun Jelip, Nicholas M. Anstey, and Tsin Wen Yeo
Table 3
Details of patients with severe Plasmodium knowlesi malaria, Sabah, Malaysia, 2007–2009*
| Patient no. | Age, y/ sex | Severity† | Parasite count | Platelets/ µL | Blood products | ICU | Inotropes | Ventilation | Dialysis | Treatment | Outcome |
|---|---|---|---|---|---|---|---|---|---|---|---|
| P. knowlesi only | |||||||||||
| 1 | 76/M | 1, 6, 7 | 3 | 17,000 | Plt | Y | N | N | N | Artesunate | S |
| 2 | 22/M | 4, 7 | 3 | 38,000 | Bld | Y | Y | Y | N | Quinine | S |
| 3 | 29/M | 2 | 4 | 16,000 | Bld, Plt | Y | N | Y | Y | Quinine | S |
| 4 | 76/F | 1, 2, 3, 4, 6, 7 | 4 | 42,000 | Bld | Y | Y | Y | Y | Quinine | D |
| 5 | 50/M | 2, 4 | 2 | 60,000 | Bld | Y | Y | N | Y | Quinine | S |
| 6 | 55/M | 2, 4, 7 | 4 | 42,000 | N | Y | Y | N | N | Quinine | S |
| 7 | 49/M | 1 | 4 | 78,000 | N | Y | N | N | N | Quinine | S |
| 8 | 38/F | 2 | 4 | 29,000 | Bld | Y | N | N | Y | Quinine | S |
| 9 | 65/M | 3, 4 | 3 | 17,000 | N | N | N | N | N | Quinine | S |
| 10 | 70/F | 2, 4, 6, 7 | 4 | 48,000 | Bld | Y | Y | Y | Y | Quinine | S |
| 11 | 65/F | 1, 2, 4, 6, 7 | 4 | 26,000 | Bld, FFP | Y | Y | Y | Y | Quinine | D |
| 12 | 75/F | 4, 6 | 3 | 22,000 | N | N | Y | N | N | Artesunate | S |
| 13 | 69/F | 7 | 2 | 130,000 | N | N | N | N | N | Artesunate | S |
| 14 | 57/M | 1, 2, 3, 4, 6, 7 | 4 | 35,000 | Bld, Plt, FFP | Y | Y | Y | Y | Artesunate | D |
| 15 | 60/M | 1 | 4 | 37,000 | N | N | N | N | N | Quinine | S |
| 16 | 44/M | 1 | 3 | 61,000 | N | N | N | N | N | Artesunate | S |
| 17 | 54/M | 4, 7 | 2 | 72,000 | N | Y | Y | N | N | Quinine | S |
| 18 | 69/M | 1, 2 | 3 | 41,000 | Bld | Y | N | N | Y | Quinine | S |
| 19 | 84/F | 2, 5, 7 | 2 | 34,000 | N | N | N | Y | N | Quinine | D |
| 20 | 54/F | 2, 4, 7 | 3 | 12,000 | Bld, Plt | Y | Y | Y | Y | Artesunate | S |
| 21 | 56/M | 4, 7 | 4 | 28,000 | N | N | Y | Y | N | Quinine | D |
| 22 |
46/M |
1, 2, 7 |
4 |
16,000 |
N |
Y |
Y |
Y |
Y |
Quinine |
D |
| P. vivax + P. knowlesi | 48/M | 1, 2, 6 | 2 | 24,000 | N | Y | N | N | Y | Artesunate | S |
| ND | 28/M | 7 | 3 | 80,000 | N | Y | N | Y | N | Artesunate | S |
*ICU, intensive care unit; Bld, blood; Plt, platelets; Y, yes; N, no; S, survived; D, died; FFP, fresh frozen plasma; ND, none detected.
†Severity criteria: 1, hyperbilirubinemia; 2, acute renal failure; 3, hypoglycemia; 4, shock; 5, blackwater fever; 6, acidosis; 7, respiratory distress.
Page created: August 15, 2011
Page updated: August 15, 2011
Page reviewed: August 15, 2011
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.