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Volume 18, Number 5—May 2012
Research
Temporal Trends in Bordetella pertussis Populations, Denmark, 1949–2010
Randi Føns Petersen
, Tine Dalby, Ditte Marie Dragsted, Frits Mooi, and Lotte Lambertsen
, Tine Dalby, Ditte Marie Dragsted, Frits Mooi, and Lotte Lambertsen
Table 2
MLVA typing results for isolates analyzed in a study of temporal trends in Bordetella pertussis populations, Denmark, 1949–2009*
| MT | No. isolates detected (% frequency) |
|||
|---|---|---|---|---|
| Total period, n = 260 isolates, 40 MTs | Period 1, n = 24 isolates, 8 MTs | Period 2, n = 51 isolates, 17 MTs | Period 3, n = 185 isolates, 23 MTs | |
| Major MTs | ||||
| 27 | 122 (47) | ND | 3 (6) | 119 (65) |
| 29 | 49 (20) | 3 (12) | 27 (53) | 19 (10) |
| 36 | 8 (3) | ND | ND | 8 (4) |
| 253† | 7 (3) | 7 (29) | ND | ND |
| 34 | 6 (2) | ND | 2 (4) | 4 (2) |
| 141 | 5 (2) | 4 (17) | 1 (2) | ND |
| 18 | 4 (1) | ND | ND | 4 (2) |
| 256† | 4 (1) | 4 (17) | ND | ND |
| 16 | 4 (1) | ND | 1 (2) | 3 (2) |
| Minor MTs‡ | 51 (20) | 6 (25) | 17 (33) | 28 (15) |
*Genetic diversity was calculated as Simpson index of diversity for each period. The genetic diversity index was calculated for MLVA types by using the online tool Comparing Partitions (www.comparingpartitions.info). Simpson index of diversity (95% CI) was 0.74 (0.69–0.79) for the total period, 0.84 (0.75–0.92) for period 1, 0.71 (0.57–0.85) for period 2, and 0.57 (0.48–0.65) for period 3. MLVA, multilocus variable-number tandem repeat analysis; MT, MLVA type; ND, none detected.
†MTs found in 1–3 isolates.
‡New MTs detected in this study.
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