Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link
Volume 18, Number 5—May 2012
Research

Novel Strain of Andes Virus Associated with Fatal Human Infection, Central Bolivia

Cristhopher D. Cruz, Brett M. ForsheyComments to Author , Efrain Vallejo, Roberto Agudo, Jorge Vargas, David L. Blazes, Carolina Guevara, V. Alberto Laguna-Torres, Eric S. Halsey, and Tadeusz J. Kochel
Author affiliations: US Naval Medical Research Unit 6, Lima, Peru (C.D. Cruz, B.M. Forshey, D.L. Blazes, C. Guevara, V.A. Laguna-Torres, E.S. Halsey); Servicio Departamental de Salud, Cochabamba, Bolivia (E. Vallejo, R. Agudo); Centro Nacional de Enfermedades Tropicales, Santa Cruz, Bolivia (J. Vargas); US Naval Medical Research Center, Silver Spring, Maryland, USA (T.J. Kochel)

Main Article

Figure 2

Phylogenetic analysis of hantaviruses from the Western Hemisphere on the basis of partial A) small and B) medium segments. Novel strains described in this study are indicated in boldface. Depicted phylogenetic reconstructions are based on Bayesian inference conducted in MrBayes (29,30). Posterior probabilities are indicated at relevant nodes. CASV, Castelo dos Sonhos virus; ANDV, Andes virus; ORNV, Oran virus; BMJV, Bermejo virus; LECV, Lechiguanas virus; BMJC, Bermejo virus; NEMV, Neembucu viru

Figure 2. . . Phylogenetic analysis of hantaviruses from the Western Hemisphere on the basis of partial A) small and B) medium segments. Novel strains described in this study are indicated in boldface. Depicted phylogenetic reconstructions are based on Bayesian inference conducted in MrBayes (29,30). Posterior probabilities are indicated at relevant nodes. Scale bar indicates nucleotide sequence divergence. CASV, Castelo dos Sonhos virus; ANDV, Andes virus; ORNV, Oran virus; BMJV, Bermejo virus; LECV, Lechiguanas virus; BMJC, Bermejo virus; NEMV, Neembucu virus; PRGV, Pergamino virus; MACV, Maciel virus; PARV, Paranoa virus; ARAV, Araraquara virus; ITAPV, Itaporanga virus; ARCV, Araucaria virus; RIOMV, Río Mamoré virus; ALPV, Alta Paraguay virus; LNV, Laguna Negra virus; CHOV, Choclo virus; SNV, Sin Nombre virus; CADV, Caño Delgadito virus; ELMCV, El Moro Canyon virus; PDOV, El Moro Canyon virus; CATV, Catacamas virus.

Main Article

References
  1. Ferrés  M, Vial  P, Marco  C, Yanez  L, Godoy  P, Castillo  C, Prospective evaluation of household contacts of persons with hantavirus cardiopulmonary syndrome in Chile. J Infect Dis. 2007;195:1563–71. DOIPubMedGoogle Scholar
  2. Khaiboullina  SF, Morzunov  SP, St Jeor  SC. Hantaviruses: molecular biology, evolution and pathogenesis. Curr Mol Med. 2005;5:773–90. DOIPubMedGoogle Scholar
  3. Jonsson  CB, Figueiredo  L, Vapalahti  O. A global perspective on hantavirus ecology, epidemiology, and disease. Clin Microbiol Rev. 2010;23:412–41. DOIPubMedGoogle Scholar
  4. Klein  SL, Calisher  CH. Emergence and persistence of hantaviruses. Curr Top Microbiol Immunol. 2007;315:217–52. DOIPubMedGoogle Scholar
  5. Milazzo  ML, Duno  G, Utrera  A, Richter  MH, Duno  F, de Manzione  N, Natural host relationships of hantaviruses native to western Venezuela. Vector Borne Zoonotic Dis. 2010;10:605–11. DOIPubMedGoogle Scholar
  6. Fulhorst  CF, Cajimat  MN, Utrera  A, Milazzo  ML, Duno  GM. Maporal virus, a hantavirus associated with the fulvous pygmy rice rat (Oligoryzomys fulvescens) in western Venezuela. Virus Res. 2004;104:139–44. DOIPubMedGoogle Scholar
  7. Powers  AM, Mercer  DR, Watts  DM, Guzman  H, Fulhorst  CF, Popov  VL, Isolation and genetic characterization of a hantavirus (Bunyaviridae: Hantavirus) from a rodent, Oligoryzomys microtis (Muridae), collected in northeastern Peru. Am J Trop Med Hyg. 1999;61:92–8.PubMedGoogle Scholar
  8. Suzuki  A, Bisordi  I, Levis  S, Garcia  J, Pereira  LE, Souza  RP, Identifying rodent hantavirus reservoirs, Brazil. Emerg Infect Dis. 2004;10:2127–34.PubMedGoogle Scholar
  9. Rosa  ES, Mills  JN, Padula  PJ, Elkhoury  MR, Ksiazek  TG, Mendes  WS, Newly recognized hantaviruses associated with hantavirus pulmonary syndrome in northern Brazil: partial genetic characterization of viruses and serologic implication of likely reservoirs. Vector Borne Zoonotic Dis. 2005;5:11–9. DOIPubMedGoogle Scholar
  10. Raboni  SM, Probst  CM, Bordignon  J, Zeferino  A, dos Santos  CN. Hantaviruses in central South America: phylogenetic analysis of the S segment from HPS cases in Paraná, Brazil. J Med Virol. 2005;76:553–62. DOIPubMedGoogle Scholar
  11. Bohlman  MC, Morzunov  SP, Meissner  J, Taylor  MB, Ishibashi  K, Rowe  J, Analysis of hantavirus genetic diversity in Argentina: S segment–derived phylogeny. J Virol. 2002;76:3765–73. DOIPubMedGoogle Scholar
  12. Padula  PJ, Colavecchia  SB, Martínez  VP, Gonzalez Della Valle  MO, Edelstein  A, Miguel  SD, Genetic diversity, distribution, and serological features of hantavirus infection in five countries in South America. J Clin Microbiol. 2000;38:3029–35.PubMedGoogle Scholar
  13. Pini  N, Levis  S, Calderón  G, Ramirez  J, Bravo  D, Lozano  E, Hantavirus infection in humans and rodents, northwestern Argentina. Emerg Infect Dis. 2003;9:1070–6.PubMedGoogle Scholar
  14. Chu  YK, Milligan  B, Owen  RD, Goodin  DG, Jonsson  CB. Phylogenetic and geographical relationships of hantavirus strains in eastern and western Paraguay. Am J Trop Med Hyg. 2006;75:1127–34.PubMedGoogle Scholar
  15. Padula  P, Martinez  VP, Bellomo  C, Maidana  S, San Juan  J, Tagliaferri  P, Pathogenic hantaviruses, northeastern Argentina and eastern Paraguay. Emerg Infect Dis. 2007;13:1211–4.PubMedGoogle Scholar
  16. Medina  RA, Torres-Perez  F, Galeno  H, Navarrete  M, Vial  PA, Palma  RE, Ecology, genetic diversity, and phylogeographic structure of Andes virus in humans and rodents in Chile. J Virol. 2009;83:2446–59. DOIPubMedGoogle Scholar
  17. Bharadwaj  M, Botten  J, Torrez-Martinez  N, Hjelle  B. Rio Mamore virus: genetic characterization of a newly recognized hantavirus of the pygmy rice rat, Oligoryzomys microtis, from Bolivia. Am J Trop Med Hyg. 1997;57:368–74.PubMedGoogle Scholar
  18. Johnson  AM, Bowen  MD, Ksiazek  TG, Williams  RJ, Bryan  RT, Mills  JN, Laguna Negra virus associated with HPS in western Paraguay and Bolivia. Virology. 1997;238:115–27. DOIPubMedGoogle Scholar
  19. Espinoza  R, Vial  P, Noriega  LM, Johnson  A, Nichol  ST, Rollin  PE, Hantavirus pulmonary syndrome in a Chilean patient with recent travel in Bolivia. Emerg Infect Dis. 1998;4:93–5. DOIPubMedGoogle Scholar
  20. Carroll  DS, Mills  JN, Montgomery  JM, Bausch  DG, Blair  PJ, Burans  JP, Hantavirus pulmonary syndrome in central Bolivia: relationships between reservoir hosts, habitats, and viral genotypes. Am J Trop Med Hyg. 2005;72:42–6.PubMedGoogle Scholar
  21. Padula  P, Della Valle  MG, Alai  MG, Cortada  P, Villagra  M, Gianella  A. Andes virus and first case report of Bermejo virus causing fatal pulmonary syndrome. Emerg Infect Dis. 2002;8:437–9. DOIPubMedGoogle Scholar
  22. Forshey  BM, Guevara  C, Laguna-Torres  VA, Cespedes  M, Vargas  J, Gianella  A, Arboviral etiologies of acute febrile illnesses in western South America, 2000–2007. PLoS Negl Trop Dis. 2010;4:e787. DOIPubMedGoogle Scholar
  23. Instituto Nacional De Estadistica. Censo de poblacion y vivienda, 2001. 2002 [cited 2012 Feb 4]. http://www.ine.gob.bo/comunitaria/comunitariaVer.aspx?Depto=03&Prov=10&Seccion=03
  24. Delgado  S, Erickson  BR, Agudo  R, Blair  PJ, Vallejo  E, Albarino  CG, Chapare virus, a newly discovered arenavirus isolated from a fatal hemorrhagic fever case in Bolivia. PLoS Pathog. 2008;4:e1000047. DOIPubMedGoogle Scholar
  25. Meissner  JD, Rowe  JE, Borucki  MK, St Jeor  SC. Complete nucleotide sequence of a Chilean hantavirus. Virus Res. 2002;89:131–43. DOIPubMedGoogle Scholar
  26. Tamura  K, Dudley  J, Nei  M, Kumar  S. MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) software version 4.0. Mol Biol Evol. 2007;24:1596–9. DOIPubMedGoogle Scholar
  27. Guindon  S, Lethiec  F, Duroux  P, Gascuel  O. PHYML Online: a web server for fast maximum likelihood-based phylogenetic inference. Nucleic Acids Res. 2005;33:W557–9. DOIPubMedGoogle Scholar
  28. Guindon  S, Delsuc  F, Dufayard  J-F, Gascuel  O. Estimating maximum likelihood phylogenies with PhyML. Methods Mol Biol. 2009;537:113–37. DOIPubMedGoogle Scholar
  29. Ronquist  F, Huelsenbeck  JP. MrBayes 3: Bayesian phylogenetic inference under mixed models. Bioinformatics. 2003;19:1572–4. DOIPubMedGoogle Scholar
  30. Huelsenbeck  JP, Ronquist  F. MRBAYES: Bayesian inference of phylogenetic trees. Bioinformatics. 2001;17:754–5. DOIPubMedGoogle Scholar
  31. Johnson  AM, de Souza  LT, Ferreira  IB, Pereira  LE, Ksiazek  TG, Rollin  PE, Genetic investigation of novel hantaviruses causing fatal HPS in Brazil. J Med Virol. 1999;59:527–35. DOIPubMedGoogle Scholar
  32. Medeiros  DB, Travassos da Rosa  ES, Aparecido  AM, Simith  DB, Carneiro  AR, Chiang  JO, Circulation of hantaviruses in the influence area of the Cuiabá-Santarém Highway. Mem Inst Oswaldo Cruz. 2010;105:665–71. DOIPubMedGoogle Scholar
  33. Loayza  R, Revollo  J, Vargas  J. Hantavirus en el Chapare Boliviano. Revista Enfermedades Infecciosas Tropicales. 2009;1:21–3.
  34. Mendes  WS, da Silva  AA, Aragão  LF, Aragão  NJ, Raposo  MD, Elkhoury  MR, Hantavirus infection in Anajatuba, Maranhao, Brazil. Emerg Infect Dis. 2004;10:1496–8.PubMedGoogle Scholar
  35. Campos  GM, Moro De Sousa  RL, Badra  SJ, Pane  C, Gomes  UA, Figueiredo  LT. Serological survey of hantavirus in Jardinopolis County, Brazil. J Med Virol. 2003;71:417–22. DOIPubMedGoogle Scholar
  36. Ferrer  JF, Jonsson  CB, Esteban  E, Galligan  D, Basombrio  MA, Peralta-Ramos  M, High prevalence of hantavirus infection in Indian communities of the Paraguayan and Argentinean Gran Chaco. Am J Trop Med Hyg. 1998;59:438–44.PubMedGoogle Scholar
  37. Sistema Nacional de Información en Salud y Vigilancia Epidemiológica. Vigilancia epidemiologica. 2011 [cited 2011 Feb 27]. http://sns.gov.bo/snis
  38. Travassos da Rosa  ES, Medeiros  DB, Nunes  MR, Simith  DB, de Souza Pereira  A, Elkhoury  MR, Pygmy rice rat as potential host of Castelo dos Sonhos hantavirus. Emerg Infect Dis. 2011;17:1527–30.PubMedGoogle Scholar

Main Article

Page created: April 12, 2012
Page updated: April 12, 2012
Page reviewed: April 12, 2012
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
file_external