Volume 18, Number 5—May 2012
Dispatch
Plasmodium vivax Malaria–associated Acute Kidney Injury, India, 2010–2011
Vivek B. Kute
, Hargovind L. Trivedi, Aruna V. Vanikar, Pankaj R. Shah, Manoj R. Gumber, Himanshu V. Patel, Jitendra G. Goswami, and Kamal V. Kanodia
, Hargovind L. Trivedi, Aruna V. Vanikar, Pankaj R. Shah, Manoj R. Gumber, Himanshu V. Patel, Jitendra G. Goswami, and Kamal V. Kanodia
Table 2
Comparison of 25 Plasmodium vivax patients with acute kidney injury, Ahmedabad, India, 2010–2011*
| Characteristic | Survived, n = 22 | Died, n = 3 | p value |
|---|---|---|---|
| Age, y | 27.7 ± 9.9 | 47.3 ± 17.5 | 0.058 |
| Hypotension not resolving after receipt of fluid, no. (%) | 0 | 3 (100) | 0.0001 |
| Mechanical ventilation, no. (%) | 1 (4.5) | 3 (100) | 0.0001 |
| Lactate dehydrogenase, U/L | 1126.3 ± 243.2 | 2300 ± 360.5 | 0.001 |
| APACHE 2 score | 16.4 ± 2.61 (9–23) | 25.3 ± 1.52 (24–27) | 0.001 |
| SOFA score | 7.73 ± 2.3 (4–11) | 13.3 ± 1.15 (12–14) | 0.001 |
| MODS score | 7.23 ± 2.26 (4–10) | 13 ± 1.0 (12–14) | 0.001 |
| GCS score | 14.5 ± 1.01 (12–15) | 12.3 ± 0.57 (12–13) | 0.013 |
| Hemoglobin, gm/L | 8.0 ± 1.71 | 8.13 ± 0.70 | 0.96 |
| Hematocrit, % | 24.5 ± 5.2 | 25.6 ± 2.3 | 0.78 |
| Leuckocytes, cells/mm3 | 9,175.9 ± 3,110 | 7,733.3 ± 3,300 | 0.49 |
| Platelets, cells/μL | 113,409 ± 96,618 | 74,000 ± 2,5159 | 0.90 |
| Total bilirubin, mg/dL | 6.1 ± 8 | 2.56 ± 0.75 | 0.72 |
| Direct bilirubin, mg/dL | 4.46 ± 6.58 | 1.76 ± 0.40 | 0.60 |
| Indirect bilirubin, mg/dL | 1.64 ± 2.23 | 0.80 ± 0.34 | 0.90 |
| Alanine aminotransferase, U/L | 66.9 ± 47.8 | 59.3 ± 29.1 | 0.96 |
| Sodium, mmol/L | 130.5 ± 7.17 | 126.6 ± 2.3 | 0.23 |
| Creatinine, mg/dL | 7.36 ± 2.7 | 7.5 ± 2.17 | 0.66 |
| Blood urea, mg/dL | 147.7 ± 57.5 | 87 ± 48.8 | 0.08 |
| No. hemodialysis sessions | 5.3 ± 3.7 | 3.33 ± 1.15 | 0.23 |
*Values are mean ± SD (range) except as indicated. APACHE, Acute Physiology and Chronic Health Evaluation; SOFA ,Sequential Organ Failure Assessment; MODS, Multiple Organ Dysfunction Score; GCS, Glasgow Coma Scale.
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