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Volume 19, Number 1—January 2013
Research

Invasive Pneumococcal Disease after Routine Pneumococcal Conjugate Vaccination in Children, England and Wales

Shamez N. LadhaniComments to Author , Mary P.E. Slack, Nick J. Andrews, Pauline A. Waight, Ray Borrow, and Elizabeth Miller
Author affiliations: Author affiliations: Health Protection Services Colindale, London, UK (S.N. Ladhani, M.P.E. Slack, N.J Andrews, P.A Waight, E. Miller); Health Protection Agency, Manchester, UK (R. Borrow)

Main Article

Table 2

Comorbidities in children with invasive pneumococcal disease, England and Wales, September 4, 2006–March 31, 2010

Comorbidity Age group, mo, no. (%)
Total, n = 1,332
3–11, n = 507 12–23, n = 446 24–59, n = 379
Total
66 (13.0)
54 (12.1)
78 (20.6)
198 (14.9)
Malignancy/immunosuppression 6 (9.1) 12 (22.2) 38 (48.7) 56 (28.3)

Hematologic malignancy

0 1 23 24

Solid-organ malignancy

3 6 7 16

Transplant*

1 1 3 5

Primary immunodeficiency

2 4 3 9

HIV infection


0
0
2
2
Congenital heart disease 22 (33.3) 7 (13.0) 7 (9.0) 36 (18.2)
Down syndrome†
9 (13.6)
5 (9.3)
9 (11.5)
23 (11.6)
Respiratory disease 10 (15.2) 11 (20.4) 6 (7.7) 27 (13.6)

Chronic lung disease

5 5 4 14

Congenital anomaly

5 5 1 11

Severe asthma on oral steroids


0
1
1
2
Gastrointestinal disease 7 (10.6) 4 (7.4) 2 (2.6) 13 (6.6)

Biliary atresia

5 0 1 6

Long-term total parenteral nutrition
 dependency‡


2
4
1
7
Neurologic disease 7 (10.6) 7 (13.0) 7 (9.0) 21 (10.6)

Cerebral insult/palsy

4 1 4 9

Congenital anomaly

2 4 2 8

Cochlear implant

0 1 1 2

Ventricular-peritoneal shunt


1
1
0
2
Sickle cell disease
2 (3.0)
3 (5.6)
6 (7.7)
11 (5.6)
Renal disease 3 (4.5) 5 (9.3) 3 (3.8) 11 (5.6)

Congenital anomaly

3 1 1 5

Metabolic renal condition

0 1 0 1

Nephrotic syndrome

0 2 2 4

Chronic renal failure

0 1 0 1

*Transplant of the heart (2), liver (1), bone marrow (1), and kidney (1),
†Congenital heart disease also was reported in 6/9, 4/5, and 7/9 children with Down syndrome in the 3 age groups, respectively.
‡Four with postnecrotizing enterocolitis with surgical resection of bowel, 2 with protein-losing enteropathy, and 1 with malabsorption syndrome.

Main Article

Page created: December 20, 2012
Page updated: December 20, 2012
Page reviewed: December 20, 2012
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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