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Volume 19, Number 12—December 2013
CME ACTIVITY - Synopsis

Potential Role of Deer Tick Virus in Powassan Encephalitis Cases in Lyme Disease–endemic Areas of New York, USA

Marc Y. El Khoury1Comments to Author , Jose F. Camargo1, Jennifer L. White, Bryon P. Backenson, Alan P. Dupuis, Kay L. Escuyer, Laura Kramer, Kirsten St. George, Debarati Chatterjee, Melissa Prusinski, Gary P. Wormser, and Susan J. Wong
Author affiliations: New York Medical College, Valhalla, NY, USA (M.Y. El Khoury, J.F. Camargo, D. Chatterjee, G.P. Wormser); Wadsworth Center, New York State Department of Health, Albany, NY, USA (J.L. White, B.P. Backenson, A.P. Dupuis II, K.L. Escuyer, L. Kramer, K. St. George, M. Prusinski, S.J. Wong)

Main Article

Figure 1

Cases of Powassan/deer tick virus encephalitis, by county, New York, USA, for 2004–2012 (A) and 1958–2003 (B) (19). A total of 14 cases occurred during 2004–2012 and 9 cases during 1958–2003. One additional case from 1958–2003 is not shown because the patient had lived in and traveled through multiple counties in the 6 weeks before illness onset (20).

Figure 1. . . Cases of Powassan/deer tick virus encephalitis, by county, New York, USA, for 2004–2012 (A) and 1958–2003 (B) (19). A total of 14 cases occurred during 2004–2012 and 9 cases during 1958–2003. One additional case from 1958–2003 is not shown because the patient had lived in and traveled through multiple counties in the 6 weeks before illness onset (20).

Main Article

References
  1. Grard  G, Moureau  G, Charrel  RN, Lemasson  JJ, Gonzalez  JP, Gallian  P, Genetic characterization of tick-borne flaviviruses: new insights into evolution, pathogenetic determinants and taxonomy. Virology. 2007;361:8092 and. DOIPubMedGoogle Scholar
  2. McLean  DM, Donohue  WL. Powassan virus: isolation of virus from a fatal case of encephalitis. Can Med Assoc J. 1959;80:70811 .PubMedGoogle Scholar
  3. Leonova  GN, Kondratov  IG, Ternovoi  VA, Romanova  EV, Protopopova  EV, Chausov  EV, Characterization of Powassan viruses from Far Eastern Russia. Arch Virol. 2009;154:81120 and. DOIPubMedGoogle Scholar
  4. Kuno  G, Artsob  H, Karabatsos  N, Tsuchiya  KR, Chang  GJ. Genomic sequencing of deer tick virus and phylogeny of Powassan-related viruses of North America. Am J Trop Med Hyg. 2001;65:6716 .PubMedGoogle Scholar
  5. Pesko  KN, Torres-Perez  F, Hjelle  BL, Ebel  GD. Molecular epidemiology of Powassan virus in North America. J Gen Virol. 2010;91:2698705 and. DOIPubMedGoogle Scholar
  6. Johnson  DK, Staples  JE, Sotir  MJ, Warshauer  DM, Davis  JP. Tickborne Powassan virus infections among Wisconsin residents. WMJ. 2010;109:917 .PubMedGoogle Scholar
  7. Telford  SR III, Armstrong  PM, Katavolos  P, Foppa  I, Garcia  AS, Wilson  ML, A new tick-borne encephalitis-like virus infecting New England deer ticks, Ixodes dammini. Emerg Infect Dis. 1997;3:16570 and. DOIPubMedGoogle Scholar
  8. Ebel  GD, Campbell  EN, Goethert  HK, Spielman  A, Telford  SR III. Enzootic transmission of deer tick virus in New England and Wisconsin sites. Am J Trop Med Hyg. 2000;63:3642 .PubMedGoogle Scholar
  9. Gholam  BI, Puksa  S, Provias  JP. Powassan encephalitis: a case report with neuropathology and literature review. CMAJ. 1999;161:141922 .PubMedGoogle Scholar
  10. Tavakoli  NP, Wang  H, Dupuis  M, Hull  R, Ebel  GD, Gilmore  EJ, Fatal case of deer tick virus encephalitis. N Engl J Med. 2009;360:2099107 and. DOIPubMedGoogle Scholar
  11. El Khoury  MY, Hull  RC, Bryant  PW, Escuyer  KL, St George  K, Wong  SJ, Diagnosis of acute deer tick virus encephalitis. Clin Infect Dis. 2013;56:e407 and. DOIPubMedGoogle Scholar
  12. Neitzel  DF, Lynfield  R, Smith  K. Powassan virus encephalitis, Minnesota, USA. Emerg Infect Dis. 2013;19:686 and. DOIPubMedGoogle Scholar
  13. Hinten  SR, Beckett  GA, Gensheimer  KF, Pritchard  E, Courtney  TM, Sears  SD, Increased recognition of Powassan encephalitis in the United States, 1999–2005. Vector Borne Zoonotic Dis. 2008;8:73340 and. DOIPubMedGoogle Scholar
  14. Hicar  MD, Edwards  K, Bloch  K. Powassan virus infection presenting as acute disseminated encephalomyelitis in Tennessee. Pediatr Infect Dis J. 2011;30:868 and. DOIPubMedGoogle Scholar
  15. Sung  S, Wurcel  AG, Whittier  S, Kulas  K, Kramer  LD, Flam  R, Powassan meningoencephalitis, New York, New York, USA. Emerg Infect Dis. 2013;19:15046 and. DOIPubMedGoogle Scholar
  16. Centers for Disease Control and Prevention. 2012 Nationally notifiable diseases and conditions and current case definitions. Atlanta: The Centers; 2012 [cited 2013 Oct 24]. http://wwwn.cdc.gov/nndss/document/2012_Case%20Definitions.pdf
  17. Wong  SJ, Demarest  VL, Boyle  RH, Wang  T, Ledizet  M, Kar  K, Detection of human anti-flavivirus antibodies with a West Nile virus recombinant antigen microsphere immunoassay. J Clin Microbiol. 2004;42:6572 and. DOIPubMedGoogle Scholar
  18. Wong  SJ, Boyle  RH, Demarest  VL, Woodmansee  AN, Kramer  LD, Li  H, Immunoassay targeting nonstructural protein 5 to differentiate West Nile virus infection from Dengue and St. Louis encephalitis virus infections and from flavivirus vaccination. J Clin Microbiol. 2003;41:421723 and. DOIPubMedGoogle Scholar
  19. Artsob  H. Powassan encephalitis. In: Monath TP, editor. The arboviruses: epidemiology and ecology. Boca Raton (FL): CRC Press, Inc.; 1989. p. 29–49.
  20. Embil  JA, Camfield  P, Artsob  H, Chase  DP. Powassan virus encephalitis resembling herpes simplex encephalitis. Arch Intern Med. 1983;143:3413 and. DOIPubMedGoogle Scholar
  21. Dupuis  M, Hull  R, Wang  H, Nattanmai  S, Glasheen  B, Fusco  H, Molecular detection of viral causes of encephalitis and meningitis in New York State. J Med Virol. 2011;83:217281 and. DOIPubMedGoogle Scholar
  22. Deibel  R, Srihongse  S, Woodall  JP. Arboviruses in New York State: an attempt to determine the role of arboviruses in patients with viral encephalitis and meningitis. Am J Trop Med Hyg. 1979;28:57782 .PubMedGoogle Scholar
  23. Centers for Disease Control and Prevention. Outbreak of Powassan encephalitis—Maine and Vermont, 1999–2001. MMWR Morb Mortal Wkly Rep. 2001;50:7614 .PubMedGoogle Scholar
  24. Centers for Disease Control and Prevention. West Nile virus disease and other arboviral diseases—United States, 2010. MMWR Morb Mortal Wkly Rep. 2011;60:100913 .PubMedGoogle Scholar
  25. Birge  J, Sonnesyn  S. Powassan virus encephalitis, Minnesota, USA. Emerg Infect Dis. 2012;18:166971 and. DOIPubMedGoogle Scholar
  26. Raval  M, Singhal  M, Guerrero  D, Alonto  A. Powassan virus infection: case series and literature review from a single institution. BMC Res Notes. 2012;5:594 and. DOIPubMedGoogle Scholar
  27. Falco  RC, Fish  D. Ticks parasitizing humans in a Lyme disease endemic area of southern New York State. Am J Epidemiol. 1988;128:114652 .PubMedGoogle Scholar
  28. Tokarz  R, Jain  K, Bennett  A, Briese  T, Lipkin  WI. Assessment of polymicrobial infections in ticks in New York State. Vector Borne Zoonotic Dis. 2010;10:21721 and. DOIPubMedGoogle Scholar
  29. Ebel  GD, Kramer  LD. Short report: duration of tick attachment required for transmission of Powassan virus by deer ticks. Am J Trop Med Hyg. 2004;71:26871 .PubMedGoogle Scholar
  30. Anderson  JF, Armstrong  PM. Prevalence and genetic characterization of Powassan virus strains infecting Ixodes scapularis in Connecticut. Am J Trop Med Hyg. 2012;87:7549 and. DOIPubMedGoogle Scholar
  31. Ebel  GD, Foppa  I, Spielman  A, Telford  SR III. A focus of deer tick virus transmission in the northcentral United States. Emerg Infect Dis. 1999;5:5704 and. DOIPubMedGoogle Scholar
  32. Brackney  DE, Nofchissey  RA, Fitzpatrick  KA, Brown  IK, Ebel  GD. Stable prevalence of Powassan virus in Ixodes scapularis in a northern Wisconsin focus. Am J Trop Med Hyg. 2008;79:9713 .PubMedGoogle Scholar
  33. Costero  A, Grayson  MA. Experimental transmission of Powassan virus (Flaviviridae) by Ixodes scapularis ticks (Acari: Ixodidae). Am J Trop Med Hyg. 1996;55:53646 .PubMedGoogle Scholar
  34. Dupuis  AP II, Peters  RJ, Prusinski  MA, Falco  RC, Ostfeld  RS, Kramer  LD. Isolation of deer tick virus (Powassan virus, lineage II) from Ixodes scapularis and detection of antibody in vertebrate hosts sampled in the Hudson Valley, New York State. Parasit Vectors. 2013;6:185.PubMedGoogle Scholar
  35. Ryder  JW, Pinger  RR, Glancy  T. Inability of Ixodes cookei and Amblyomma americanum nymphs (Acari: Ixodidae) to transmit Borrelia burgdorferi. J Med Entomol. 1992;29:52530 .PubMedGoogle Scholar
  36. Tunkel  AR, Glaser  CA, Bloch  KC, Sejvar  JJ, Marra  CM, Roos  KL, The management of encephalitis: clinical practice guidelines by the Infectious Diseases Society of America. Clin Infect Dis. 2008;47:30327 and. DOIPubMedGoogle Scholar
  37. Portolani  M, Pietrosemoli  P, Meacci  M, Sabbatini  AM, Pecorari  M, Mantovani  G, Detection of Epstein-Barr virus DNA in cerebrospinal fluid from immunocompetent individuals with brain disorders. New Microbiol. 1998;21:779 .PubMedGoogle Scholar
  38. Tyler  KL. Update on herpes simplex encephalitis. Rev Neurol Dis. 2004;1:16978 .PubMedGoogle Scholar

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1These authors contributed equally to this article.

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Page updated: December 11, 2013
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