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Volume 19, Number 3—March 2013
Dispatch

Hepatitis E Virus Mixed Infection in Immunocompetent Patient

Donald B. SmithComments to Author , Jeff Vanek, Louise Wellington, Ingolfur Johannessen, Sandeep Ramalingam, and Peter Simmonds
Author affiliations: Author affiliations: University of Edinburgh, Edinburgh, Scotland, United Kingdom (D.B.S., P.S.); Royal Infirmary of Edinburgh, Edinburgh (J.V., I.J., S.R.); NHS Lothian, Edinburgh (L.W.)

Main Article

Figure

Phylogenetic tree of hepatitis E virus hypervariable region variants. A neighbor-joining tree of hypervariable region sequences was constructed by using MEGA 4 (15). A and B indicate sequences for virus populations A and B. Sequences from the patient studied here (patient 21) belonging to virus population A are indicated by a solid square, and those belonging to virus population B are indicated by a solid circle. Other sequences obtained in the same laboratory are indicated by an open circle. Cl

Figure. . . Phylogenetic tree of hepatitis E virus hypervariable region variants. A neighbor-joining tree of hypervariable region sequences was constructed by using MEGA 4 (15). A and B indicate sequences for virus populations A and B. Sequences from the patient studied here (patient 21) belonging to virus population A are indicated by a solid square, and those belonging to virus population B are indicated by a solid circle. Other sequences obtained in the same laboratory are indicated by an open circle. Closely related genotype 3 sequences obtained from GenBank are identified by their accession number. Bootstrap support (1,000 replicates) for branches of >70% are indicated. Scale bar indicates nucleotide substitutions per site.

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References
  1. Moal  V, Gerolami  R, Colson  P. First human case of co-infection with two different subtypes of hepatitis E virus. Intervirology. 2012;55:484–7 and. DOIPubMedGoogle Scholar
  2. Nguyen  HT, Torian  U, Faulk  K, Mather  K, Engle  RE, Thompson  E, A naturally occurring human/hepatitis E recombinant virus predominates in serum but not in faeces of a chronic hepatitis E patient and has a growth advantage in cell culture. J Gen Virol. 2012;93:526–30 and. DOIPubMedGoogle Scholar
  3. Kamar  N, Bendall  R, Legrand-Abravanel  F, Xia  NS, Ijaz  S, Izopet  J, Hepatitis E. Lancet. 2012;379:2477–88 and. DOIPubMedGoogle Scholar
  4. Takahashi  M, Nishizawa  T, Yoshikawa  A, Sato  S, Isoda  N, Ido  K, Identification of two distinct genotypes of hepatitis E virus in a Japanese patient with acute hepatitis who had not travelled abroad. J Gen Virol. 2002;83:1931–40 .PubMedGoogle Scholar
  5. Shrestha  SM, Shrestha  S, Tsuda  F, Nishizawa  T, Gotanda  Y, Takeda  N, Molecular investigation of hepatitis E virus infection in patients with acute hepatitis in Kathmandu, Nepal. J Med Virol. 2003;69:207–14 and. DOIPubMedGoogle Scholar
  6. Smith  DB, Vanek  J, Ramalingam  S, Johannessen  I, Templeton  K, Simmonds  P. Evolution of the hepatitis E virus hypervariable region. J Gen Virol. 2012;93:2408–18 and. DOIPubMedGoogle Scholar
  7. Takahashi  K, Toyota  J, Karino  Y, Kang  JH, Maekubo  H, Abe  N, Estimation of the mutation rate of hepatitis E virus based on a set of closely related 7.5-year-apart isolates from Sapporo, Japan. Hepatol Res. 2004;29:212–5 and. DOIPubMedGoogle Scholar
  8. Abe  K, Inchauspe  G, Fujisawa  K. Genomic characterisation and mutation rate of hepatitis C virus isolated from a patient who contracted hepatitis during an epidemic on non-A, non-B hepatitis in Japan. J Gen Virol. 1992;73:2725–9 and. DOIPubMedGoogle Scholar
  9. Colson  P, Borentain  P, Queyriaux  B, Kaba  M, Moal  V, Gallian  P, Pig liver sausage as a source of hepatitis E virus transmission to humans. J Infect Dis. 2010;202:825–34 and. DOIPubMedGoogle Scholar
  10. Di Bartolo  I, Diez-Valcarce  M, Vasickova  P, Kralik  P, Hernandez  M, Angeloni  G, Hepatitis E virus in pork production chain in Czech Republic, Italy, and Spain, 2010. Emerg Infect Dis. 2012;18:1282–9 and. DOIPubMedGoogle Scholar
  11. Lewis  HC, Boisson  S, Ijaz  S, Hewitt  K, Ngui  SL, Boxall  E, Hepatitis E in England and Wales. Emerg Infect Dis. 2008;14:165–7 and. DOIPubMedGoogle Scholar
  12. Ijaz  S, Szypulska  R, Tettmar  KI, Kitchen  A, Tedder  RS. Detection of hepatitis E virus RNA in plasma mini-pools from blood donors in England. Vox Sang. 2012;102:272 and. DOIPubMedGoogle Scholar
  13. Dalton  HR, Stableforth  W, Thurairajah  P, Hazeldine  S, Remnarace  R, Usama  W, Autochthonous hepatitis E in Southwest England: natural history, complications and seasonal variation, and hepatitis E virus IgG seroprevalence in blood donors, the elderly and patients with chronic liver disease. Eur J Gastroenterol Hepatol. 2008;20:784–90 and. DOIPubMedGoogle Scholar
  14. Wang  H, Zhang  W, Ni  B, Shen  H, Song  Y, Wang  X, Recombination analysis reveals a double recombination event in hepatitis E virus. Virol J. 2010;7:129. DOIPubMedGoogle Scholar
  15. Tamura  K, Dudley  J, Nei  M, Kumar  S. MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) software version 4.0. Mol Biol Evol. 2007;24:1596–9 and. DOIPubMedGoogle Scholar

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