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Volume 19, Number 8—August 2013


Accuracy of Diagnostic Methods and Surveillance Sensitivity for Human Enterovirus, South Korea, 1999–2011

Ji-Yeon Hyeon, Seoyeon Hwang, Hyejin Kim, Jaehyoung Song, Jeongbae Ahn, Byunghak Kang, Kisoon Kim, Wooyoung Choi, Jae Keun Chung, Cheon-Hyun Kim, Kyungsoon Cho, Youngmee Jee, Jonghyun Kim, Kisang Kim, Sun-Hee Kim, Min-Ji Kim, and Doo-Sung CheonComments to Author 
Author affiliations: Korea Center for Disease Control and Prevention, Cheongwon-gun, Chungcheongbuk-do, South Korea (J.-Y. Hyeon, S. Hwang, H. Kim, J. Song, J. Ahn, B. Kang, Kisoon Kim, W. Choi, Kisang Kim, D.-S. Cheon); Public Health and Environment Institute of Gwangju, Gwangju, South Korea (J.K. Chung, S.-H. Kim, M.-J. Kim); Public Health and Environment Institute of Jeollabukdo, Imsil-gun, Jeollabukdo, South Korea (C.-H. Kim); Public Health and Environment Institute of Busan, Busan, South Korea (K. Cho); World Health Organization, Western Pacific Region, Manila, Philippines (Y. Jee); Catholic University College of Medicine, Suwon, Kyeonggido, South Korea (J. Kim)

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Table 1

Analysis of diagnostic methods for detecting human EV and surveillance outcomes, South Korea, 1999–2011*

Year No. samples No. (%) positive Average % positive
Phase I† 20.5
1999 372 133 (35.8) NA
2000 261 30 (11.5) NA
2001 676 26 (3.80) NA
2002 1,272 361 (28.4) NA
2003 264 66 (25.0) NA
2004 314 33 (10.5) NA
Phase II‡ 26.4
2005 890 382 (42.9) NA
2006 1,059 238 (22.5) NA
2007 1,131 193 (17.1) NA
Phase III§ 39.2
2008 2,332 1,264 (54.2) NA
2009 2,766 869 (31.4) NA
2010 1,477 566 (38.3) NA
2011 1,843 601 (32.6) NA
Total 14,657 4,762 (32.5) NA

*EV, enterovirus; NA, not applicable.
†During phase I, human EV was detected and serotyped by using cell culture.
‡During phase II, human EV was detected by reverse transcription PCR (RT-PCR) and genotyped by sequencing of virus capsid protein (VP) 1 region.
§During phase III, human EV was detected by real-time RT-PCR and genotyped by sequencing of the VP1 region.

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