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Volume 19, Number 9—September 2013
Dispatch

Benznidazole Treatment of Chagasic Encephalitis in Pregnant Woman with AIDS

Margarita BisioComments to Author , Jaime Altcheh, Jorge Lattner, Guillermo Moscatelli, Valeria Fink, Juan M. Burgos, Facundo García Bournissen, Alejandro G. Schijman, and Héctor Freilij
Author affiliations: Hospital de Niños Ricardo Gutiérrez, Buenos Aires, Argentina (M. Bisio, J. Altcheh, G. Moscatelli, F. García Bournissen, H. Freilij); Instituto de Investigaciones en Ingeniería Genética y Biología Molecular Dr Héctor N. Torres, Buenos Aires (M. Bisio, A.G. Schijman); Hospital Juan A. Fernández, Buenos Aires (J. Lattner, V. Fink); Facultad de Medicina de la Universidad de Buenos Aires, Buenos Aires (J.M. Burgos)

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Figure

Diagnosis, treatment, and prophylaxis monitoring of Trypanosoma cruzi infection in a pregnant woman and her daughter. The mother, who had chagasic encephalitis and AIDS, was treated with benznidazole (Bz). Po, positive; Ng, negative; Nd, not determined; results of ELISA were considered positive when R was >1.2); IHA, indirect hemagglutination assay (IHA was considered positive when titers were >16); kDNA-PCR, kinetoplast DNA-PCR; qPCR, quantitative PCR (dynamic range of detection: 1–105

Figure. . Diagnosis, treatment, and prophylaxis monitoring of Trypanosoma cruzi infection in a pregnant woman and her daughter. The mother, who had chagasic encephalitis and AIDS, was treated with benznidazole (Bz). Results of ELISA were considered positive when R was >1.2); results of IHA were considered positive when titers were >16. Po, positive; Ng, negative; Nd, not determined; IHA, indirect hemagglutination assay; kDNA-PCR, kinetoplast DNA-PCR; qPCR, quantitative PCR (dynamic range of detection: 1–105 parasite equivalents/mL, amplification efficiency 0.95, R2 = 0.996); par/mL, parasite equivalents/mL of blood; NQ, positive but not quantifiable; MRI, magnetic resonance imaging; gwk, gestational week; pd, postdelivery; tmt, Bz treatment (5 mg/kg/d); HAART, highly active antiretroviral therapy; ppx, Bz prophylaxis (5 mg/kg/3× per week).

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Page created: August 20, 2013
Page updated: August 20, 2013
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