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Volume 20, Number 2—February 2014

Replicative Capacity of MERS Coronavirus in Livestock Cell Lines

Isabella Eckerle, Victor M. Corman, Marcel A. Müller, Matthias Lenk, Rainer G. Ulrich, and Christian DrostenComments to Author 
Author affiliations: University of Bonn Medical Centre, Bonn, Germany (I. Eckerle, V.M. Corman, M.A. Müller, C. Drosten); Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Germany (M. Lenk, R.G. Ulrich)

Main Article


Characteristics of mammalian cell lines used in a study designed to narrow the search for the intermediate mammalian host of Middle East respiratory syndrome coronavirus

Designation Species of origin Mammalian order Organ of origin Cell type
ZN-R Goat (Capra hircus)* Artiodactyla Kidney Primary
ZLu-R Goat (C. hircus)* Artiodactyla Lung Primary
LGK-1-R Alpaca (Llama pacos)* Artiodactyla Kidney Primary
TT-R.B Arabian camel (Camelus dromedarius)* Artiodactyla Umbilical cord Immortalized
PO Sheep (Ovis aries)* Artiodactyla Kidney Immortalized
KN-R Cattle (Bos taurus)* Artiodactyla Kidney Primary
KLu-R Cattle (B. taurus)* Artiodactyla Lung Primary
MyglaAEC.B Bank vole (Myodes glareolus)* Rodentia Trachea Immortalized
Crocsu-Lu Lesser white-toothed shrew (Crocidura suaveolens)* Soricomorpha Lung Immortalized
PipNi Common pipistrelle (Pipistrellus pipistrellus)* Chiroptera Kidney Immortalized
A549 Human (Homo sapiens) Primates Lung Immortalized
Vero E6 African green monkey (Chlorocebus aethiops) Primates Kidney Immortalized

*Species of origin was confirmed by sequencing of the cytochrome c subunit oxidase I gene.
†Parents and the calf phenotypically resembled C. bactrianus. The most likely explanation is cross-breeding between the 2 species with mitochondria stemming from a C. dromedarius mother in one of the former generations.

Main Article

Page created: January 17, 2014
Page updated: January 17, 2014
Page reviewed: January 17, 2014
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