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Volume 20, Number 4—April 2014

Nosocomial Drug-Resistant Bacteremia in 2 Cohorts with Cryptococcal Meningitis, Africa

Radha RajasinghamComments to Author , Darlisha Williams, David B. Meya, Graeme Meintjes, David R. Boulware, and James Scriven
Author affiliations: University of Minnesota, Minneapolis, Minnesota, USA (R. Rajasingham, D. Williams, D.B. Meya, D.R. Boulware); Makerere University, Kampala, Uganda (D. Williams, D.B. Meya); University of Cape Town, Cape Town, South Africa (G. Meintjes, J. Scriven); Imperial College London, London, UK (G. Meintjes); Liverpool School of Tropical Medicine, Liverpool, UK (J. Scriven)

Main Article


Characteristics of 28 patients with cryptococcal meningitis, Uganda and South Africa, November 2010–April 2013*

Patient Blood culture isolate Hospital 30-d outcome Ceftriaxone susceptibility† Fluoroquinolone susceptibility†
1 Staphylococcus aureus (MRSA) K Died R NT
2 S. aureus (MRSA) K Survived R NT
3 S.. aureus (MRSA) C Survived R S
4 S. aureus (MRSA) C Survived R R
5 S. aureus (MRSA) C Died R S
6 S. aureus (MSSA) K Survived S NT
7 S. aureus (MSSA) K Survived S NT
8‡ S. aureus (MRSA) C Survived R R
8 Enterobacter cloacae C Survived R S
9 Klebsiella pneumoniae K Survived R R
10 K. pneumoniae K Died R R
11 K. pneumoniae K Survived S S
12 K. pneumoniae K Died R S
13 K. pneumoniae K Died R R
14 K. pneumoniae K Died R R
15 K. pneumoniae K Survived R R
16 K. pneumoniae C Survived R NT
17 K. pneumoniae C Died R S
18 Pseudomonas putida K Died S S
19 Pseudomonas aeruginosa K Survived R R
20 Pseudomonas spp. K Died R NT
21 Salmonella spp. K Survived S S
22 Salmonella spp. K Died S S
23 Burkholderia cepacia K Survived R NT
24 B. cepacia K Survived S S
25 Citrobacter freundii K Died R S
26 Acinetobacter baumanii K Survived R S
27 Enterobacter spp. K Died R R
28‡ Enterobacter cloacae C Survived R S
28 Stenotrophomonas maltophilia C Survived R R

*Sixteen (57%) of 28 patients survived; 7 (23%) of 30 isolates were susceptible to ceftriaxone, and 13 (54%) of 24 isolates were susceptible to fluoroquinolone. MSRA, methicillin-resistant S aureus; K, Kampala, Uganda; R, resistant; NT, not tested; C, Cape Town, South Africa; S, sensitive; MSSA, methicillin-sensitive S. aureus.
†Drug sensitivity testing performed by using the Kirby-Bauer method in Cape Town, South Africa, and a Phoenix Automated Microbiology System (Becton, Dickinson, Franklin Lakes, NJ, USA) in Kampala, Uganda.
‡Two patients each had 2 episodes of bacteremia.

Main Article

Page created: March 18, 2014
Page updated: March 18, 2014
Page reviewed: March 18, 2014
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