Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link
Volume 20, Number 4—April 2014
Etymologia

Etymologia: Pertactin

Cite This Article

Pertactin [per-takʹtin]

From per- (pertussis) + tactus (Latin, “to touch”), pertactin is a virulence factor of Bordetella pertussis that promotes adhesion to tracheal epithelial cells and resistance to neutrophil-mediated clearance and is a component of acellular pertussis vaccines. Pertactin-negative B. pertussis has been reported in several countries, and its prevalence in the United States has increased in recent years. However, evidence suggests that other components of current pertussis vaccines provide protection against pertactin-negative strains.

Top

References

  1. Inatsuka  CS, Xu  Q, Vujkovic-Cvijin  I, Wong  S, Stibitz  S, Miller  JF, Pertactin is required for Bordetella species to resist neutrophil-mediated clearance. Infect Immun. 2010;78:29019 . DOIPubMed
  2. Leininger  E, Roberts  M, Kenimer  JG, Charles  IG, Fairweather  N, Novotny  P, Pertactin, an Arg-Gly-Asp–containing Bordetella pertussis surface protein that promotes adherence of mammalian cells. Proc Natl Acad Sci U S A. 1991;88:3459. DOIPubMed
  3. Pawloski  LC, Queenan  AM, Cassiday  PK. Prevalence and molecular characterization of pertactin-deficient Bordetella pertussis in the United States. Proc Natl Acad Sci USA. 1991;88:345–9. Clin Vaccine Immunol. 2014;21:11925. DOIPubMed

Top

Cite This Article

DOI: 10.3201/eid2004.et2004

Related Links

Top

Table of Contents – Volume 20, Number 4—April 2014

Page created: February 28, 2014
Page updated: February 28, 2014
Page reviewed: February 28, 2014
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
file_external