Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link
Volume 21, Number 10—October 2015
CME ACTIVITY - Synopsis

Invasive Disease Caused by Nontypeable Haemophilus influenzae

Jeroen D. LangereisComments to Author  and Marien I. de Jonge
Author affiliations: Radboud University Medical Center, Nijmegen, the Netherlands

Main Article

Figure 2

Number of recorded non–serotype b capsulated Haemophilus influenzae (Hi) isolates from blood or cerebrospinal fluid in the Netherlands, by year, 1992–2013. Adapted from (6).

Figure 2. Number of recorded non–serotype b capsulated Haemophilus influenzae (Hi) isolates from blood or cerebrospinal fluid in the Netherlands, by year, 1992–2013. Adapted from (6).

Main Article

References
  1. Van Eldere  J, Slack  MP, Ladhani  S, Cripps  AW. Non-typeable Haemophilus influenzae, an under-recognised pathogen. Lancet Infect Dis. 2014;14:128192. DOIPubMedGoogle Scholar
  2. Adam  HJ, Richardson  SE, Jamieson  FB, Rawte  P, Low  DE, Fisman  DN. Changing epidemiology of invasive Haemophilus influenzae in Ontario, Canada: evidence for herd effects and strain replacement due to Hib vaccination. Vaccine. 2010;28:40738. DOIPubMedGoogle Scholar
  3. Biesbroek  G, Wang  X, Keijser  BJ, Eijkemans  RM, Trzcinski  K, Rots  NY, Seven-valent pneumococcal conjugate vaccine and nasopharyngeal microbiota in healthy children. Emerg Infect Dis. 2014;20:20110. DOIPubMedGoogle Scholar
  4. Resman  F, Ristovski  M, Ahl  J, Forsgren  A, Gilsdorf  JR, Jasir  A, Invasive disease caused by Haemophilus influenzae in Sweden 1997–2009; evidence of increasing incidence and clinical burden of non-type b strains. Clin Microbiol Infect. 2011;17:163845. DOIPubMedGoogle Scholar
  5. Spijkerman  J, Prevaes  SM, van Gils  EJ, Veenhoven  RH, Bruin  JP, Bogaert  D, Long-term effects of pneumococcal conjugate vaccine on nasopharyngeal carriage of S. pneumoniae, S. aureus, H. influenzae and M. catarrhalis. PLoS ONE. 2012;7:e39730. DOIPubMedGoogle Scholar
  6. Academic Medical Center; National Institute of Public Health and the Environment. Bacterial meningitis in the Netherlands annual report 2013. Amsterdam: Netherlands Reference Laboratory for Bacterial Meningitis; 2014 [cited 2014 Nov 14]. http://www.amc.nl/web/file?uuid=4160e2a0-0b21-4d2b-a3e3-3538d75b880f&owner=7a3a0763-4af0-41eb-b207-963f8d0db459
  7. Kastrin  T, Paragi  M, Kolman  J, Cizman  M, Kraigher  A, Gubina  M, Characterisation of invasive Haemophilus influenzae isolates in Slovenia, 1993–2008. Eur J Clin Microbiol Infect Dis. 2010;29:6618. DOIPubMedGoogle Scholar
  8. MacNeil  JR, Cohn  AC, Farley  M, Mair  R, Baumbach  J, Bennett  N, Current epidemiology and trends in invasive Haemophilus influenzae disease—United States, 1989–2008. Clin Infect Dis. 2011;53:12306. DOIPubMedGoogle Scholar
  9. van Wessel  K, Rodenburg  GD, Veenhoven  RH, Spanjaard  L, van der Ende  A, Sanders  EA. Nontypeable Haemophilus influenzae invasive disease in The Netherlands: a retrospective surveillance study 2001–2008. Clin Infect Dis. 2011;53:e17. DOIPubMedGoogle Scholar
  10. Cremers  AJ, Sprong  T, Schouten  JA, Walraven  G, Hermans  PW, Meis  JF, Effect of antibiotic streamlining on patient outcome in pneumococcal bacteraemia. J Antimicrob Chemother. 2014;69:225864. DOIPubMedGoogle Scholar
  11. Brown  VM, Madden  S, Kelly  L, Jamieson  FB, Tsang  RS, Ulanova  M. Invasive Haemophilus influenzae disease caused by non-type b strains in Northwestern Ontario, Canada, 2002–2008. Clin Infect Dis. 2009;49:12403. DOIPubMedGoogle Scholar
  12. Millar  EV, O’Brien  KL, Watt  JP, Lingappa  J, Pallipamu  R, Rosenstein  N, Epidemiology of invasive Haemophilus influenzae type A disease among Navajo and White Mountain Apache children, 1988–2003. Clin Infect Dis. 2005;40:82330. DOIPubMedGoogle Scholar
  13. Bruce  MG, Deeks  SL, Zulz  T, Navarro  C, Palacios  C, Case  C, Epidemiology of Haemophilus influenzae serotype a, North American Arctic, 2000–2005. Emerg Infect Dis. 2008;14:4855. DOIPubMedGoogle Scholar
  14. Ladhani  SN, Collins  S, Vickers  A, Litt  DJ, Crawford  C, Ramsay  ME, Invasive Haemophilus influenzae serotype e and f disease, England and Wales. Emerg Infect Dis. 2012;18:72532 .DOIPubMedGoogle Scholar
  15. Sutton  A, Schneerson  R, Kendall-Morris  S, Robbins  JB. Differential complement resistance mediates virulence of Haemophilus influenzae type b. Infect Immun. 1982;35:95104 .PubMedGoogle Scholar
  16. Lipsitch  M. Vaccination against colonizing bacteria with multiple serotypes. Proc Natl Acad Sci U S A. 1997;94:65716. DOIPubMedGoogle Scholar
  17. Berndsen  MR, Erlendsdottir  H, Gottfredsson  M. Evolving epidemiology of invasive Haemophilus infections in the post-vaccination era: results from a long-term population-based study. Clin Microbiol Infect. 2012;18:91823. DOIPubMedGoogle Scholar
  18. Block  SL, Hedrick  J, Harrison  CJ, Tyler  R, Smith  A, Findlay  R, Community-wide vaccination with the heptavalent pneumococcal conjugate significantly alters the microbiology of acute otitis media. Pediatr Infect Dis J. 2004;23:82933. DOIPubMedGoogle Scholar
  19. Casey  JR, Pichichero  ME. Changes in frequency and pathogens causing acute otitis media in 1995–2003. Pediatr Infect Dis J. 2004;23:8248. DOIPubMedGoogle Scholar
  20. Tamir  SO, Roth  Y, Dalal  I, Goldfarb  A, Grotto  I, Marom  T. Changing trends of acute otitis media bacteriology in central Israel in the pneumococcal conjugate vaccines era. Pediatr Infect Dis J. 2015;34:1959. DOIPubMedGoogle Scholar
  21. Wang  X, Mair  R, Hatcher  C, Theodore  MJ, Edmond  K, Wu  HM, Detection of bacterial pathogens in Mongolia meningitis surveillance with a new real-time PCR assay to detect Haemophilus influenzae. Int J Med Microbiol. 2011;301:3039. DOIPubMedGoogle Scholar
  22. Satola  SW, Collins  JT, Napier  R, Farley  MM. Capsule gene analysis of invasive Haemophilus influenzae: accuracy of serotyping and prevalence of IS1016 among nontypeable isolates. J Clin Microbiol. 2007;45:32308. DOIPubMedGoogle Scholar
  23. Davis  GS, Sandstedt  SA, Patel  M, Marrs  CF, Gilsdorf  JR. Use of bexB to detect the capsule locus in Haemophilus influenzae. J Clin Microbiol. 2011;49:2594601. DOIPubMedGoogle Scholar
  24. Mell  JC, Lee  JY, Firme  M, Sinha  S, Redfield  RJ. Extensive cotransformation of natural variation into chromosomes of naturally competent Haemophilus influenzae. G3 (Bethesda). 2014;4:717–31. PMID: 24569039. http://dx.doi:DOIGoogle Scholar
  25. Langereis  JD, Stol  K, Schweda  EK, Twelkmeyer  B, Bootsma  HJ, de Vries  SP, Modified lipooligosaccharide structure protects nontypeable Haemophilus influenzae from IgM-mediated complement killing in experimental otitis media. MBio. 2012;3:e00079-12. DOIPubMedGoogle Scholar
  26. Langereis  JD, van Dongen  TM, Stol  K, Venekamp  RP, Schilder  AG, Hermans  PW. Resistance to complement-mediated killing and IgM binding to non-typeable Haemophilus influenzae is not altered when ascending from the nasopharynx to the middle ears in children with otitis media. Med Microbiol Immunol (Berl). 2013;202:40715. DOIPubMedGoogle Scholar
  27. Fox  KL, Atack  JM, Srikhanta  YN, Eckert  A, Novotny  LA, Bakaletz  LO, Selection for phase variation of LOS biosynthetic genes frequently occurs in progression of non-typeable Haemophilus influenzae infection from the nasopharynx to the middle ear of human patients. PLoS ONE. 2014;9:e90505. DOIPubMedGoogle Scholar
  28. Bajanca-Lavado  MP, Simoes  AS, Betencourt  CR, Sa-Leao  R. The Portuguese Group for Study of Haemophilus influenzae invasive infection. Characteristics of Haemophilus influenzae invasive isolates from Portugal following routine childhood vaccination against H. influenzae serotype b (2002–2010). Eur J Clin Microbiol Infect Dis. 2014;33:60310. DOIPubMedGoogle Scholar
  29. Langereis  JD, Weiser  JN. Shielding of a lipooligosaccharide IgM epitope allows evasion of neutrophil-mediated killing of an invasive strain of nontypeable Haemophilus influenzae. MBio. 2014;5:e01478-14. DOIPubMedGoogle Scholar
  30. Hallström  T, Resman  F, Ristovski  M, Riesbeck  K. Binding of complement regulators to invasive nontypeable Haemophilus influenzae isolates is not increased compared to nasopharyngeal isolates, but serum resistance is linked to disease severity. J Clin Microbiol. 2010;48:9217. DOIPubMedGoogle Scholar
  31. Zwahlen  A, Kroll  JS, Rubin  LG, Moxon  ER. The molecular basis of pathogenicity in Haemophilus influenzae: comparative virulence of genetically-related capsular transformants and correlation with changes at the capsulation locus cap. Microb Pathog. 1989;7:22535. DOIPubMedGoogle Scholar
  32. De Chiara  M, Hood  D, Muzzi  A, Pickard  DJ, Perkins  T, Pizza  M, Genome sequencing of disease and carriage isolates of nontypeable Haemophilus influenzae identifies discrete population structure. Proc Natl Acad Sci U S A. 2014;111:543944. DOIPubMedGoogle Scholar
  33. Fleury  C, Su  YC, Hallstrom  T, Sandblad  L, Zipfel  PF, Riesbeck  K. Identification of a Haemophilus influenzae factor H–binding lipoprotein involved in serum resistance. J Immunol. 2014;192:591323. DOIPubMedGoogle Scholar
  34. Blain  A, MacNeil  J, Wang  X, Bennett  N, Farley  MM, Harrison  LH, Invasive Haemophilus influenzae disease in adults >65 years, United States. Open Forum Infect Dis. 2011;2014:1:ofu044. PMID: 25734116. http://dx.doi:10.1093/ofid/ofu044
  35. Lozano  R, Naghavi  M, Foreman  K, Lim  S, Shibuya  K, Aboyans  V, Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2012;380:2095128. DOIPubMedGoogle Scholar
  36. Hawdon  N, Biman  B, McCready  W, Brigden  M, Malik  S, Vergidis  D, Antibody against Haemophilus influenzae protein D in patients with chronic conditions causing secondary immunodeficiency. Vaccine. 2012;30:12358. DOIPubMedGoogle Scholar
  37. Nakamura  S, Shchepetov  M, Dalia  AB, Clark  SE, Murphy  TF, Sethi  S, Molecular basis of increased serum resistance among pulmonary isolates of non-typeable Haemophilus influenzae. PLoS Pathog. 2011;7:e1001247. DOIPubMedGoogle Scholar
  38. Micol  R, Kayal  S, Mahlaoui  N, Beaute  J, Brosselin  P, Dudoit  Y, Protective effect of IgM against colonization of the respiratory tract by nontypeable Haemophilus influenzae in patients with hypogammaglobulinemia. J Allergy Clin Immunol. 2012;129:7707. DOIPubMedGoogle Scholar
  39. Shi  Y, Agematsu  K, Ochs  HD, Sugane  K. Functional analysis of human memory B-cell subpopulations: IgD+CD27+ B cells are crucial in secondary immune response by producing high affinity IgM. Clin Immunol. 2003;108:12837. DOIPubMedGoogle Scholar
  40. Shaw  AC, Goldstein  DR, Montgomery  RR. Age-dependent dysregulation of innate immunity. Nat Rev Immunol. 2013;13:87587. DOIPubMedGoogle Scholar

Main Article

Page created: September 11, 2015
Page updated: September 11, 2015
Page reviewed: September 11, 2015
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
file_external