Volume 21, Number 11—November 2015
Dispatch
Invasive Pneumococcal Disease 3 Years after Introduction of 10-Valent Pneumococcal Conjugate Vaccine, the Netherlands
Table 1
Number of IPD cases and cumulative incidence ratios determined on the basis of sentinel surveillance data, the Netherlands*
Serotype and patient age group, y |
No. cases | Comparison, CIR (95% CI) | ||||||
---|---|---|---|---|---|---|---|---|
Pre-PCV7, 2004–2006 |
Pre-PCV10, 2009–2011 |
Early post-PCV10, 2011–2013 |
3 years post-PCV10, 2013–2014 |
Pre-PCV10 vs. pre-PCV7 |
Early post-PCV10 vs. pre-PCV10 |
3 years post-PCV10 vs. early post-PCV10 |
||
All | ||||||||
<2 | 75 | 30 | 15 | 5 | 0.43 (0.28–0.65) | 0.51 (0.27–0.94) | 0.69 (0.25–1.90) | |
2–4 | 25 | 12 | 9 | 4 | 0.53 (0.27–1.05) | 0.75 (0.32–1.79) | 0.89 (0.27–2.89) | |
5–17 | 22 | 23 | 17 | 8 | 1.04 (0.58–1.87) | 0.75 (0.40–1.40) | 0.95 (0.41–2.20) | |
18–49 | 197 | 184 | 201 | 73 | 0.96 (0.78–1.17) | 1.10 (0.90–1.34) | 0.73 (0.56–0.96) | |
50–64 | 273 | 326 | 341 | 134 | 1.09 (0.93–1.28) | 1.03 (0.88–1.19) | 0.78 (0.64–0.95) | |
>65 | 717 | 622 | 703 | 338 | 0.78 (0.70–0.87) | 1.06 (0.95–1.18) | 0.91 (0.80–1.03) | |
Total |
1,309 |
1,197 |
1,286 |
562 |
0.90 (0.83–0.97) |
1.06 (0.98–1.15) |
0.87 (0.79–0.96) |
|
PCV7 | ||||||||
<2 | 50 | 1 | 2 | 0 | 0.02 (0.00–0.16) | 2.03 (0.18–22.33) | NC | |
2–4 | 18 | 2 | 1 | 0 | 0.12 (0.03–0.53) | 0.50 (0.05–5.55) | NC | |
5–17 | 11 | 6 | 2 | 1 | 0.54 (0.20–1.47) | 0.34 (0.07–1.67) | 1.01 (0.09–11.1) | |
18–49 | 63 | 35 | 17 | 2 | 0.57 (0.38–0.86) | 0.49 (0.27–0.87) | 0.24 (0.05–1.03) | |
50–64 | 120 | 53 | 25 | 7 | 0.40 (0.29–0.56) | 0.46 (0.29–0.74) | 0.56 (0.24–1.29) | |
>65 | 344 | 112 | 54 | 20 | 0.29 (0.24–0.36) | 0.45 (0.33–0.62) | 0.70 (0.42–1.17) | |
Total |
606 |
209 |
101 |
30 |
0.34 (0.29–0.40) |
0.48 (0.38–0.61) |
0.59 (0.39–0.89) |
|
Non-PCV7 | ||||||||
<2 | 25 | 29 | 13 | 5 | 1.24 (0.73–2.12) | 0.45 (0.24–0.87) | 0.80 (0.28–2.23) | |
2–4 | 7 | 10 | 8 | 4 | 1.57 (0.60–4.13) | 0.80 (0.32–2.04) | 1.00 (0.30–3.32) | |
5–17 | 11 | 17 | 15 | 7 | 1.54 (0.72–3.30) | 0.89 (0.44–1.78) | 0.94 (0.38–2.31) | |
18–49 | 134 | 149 | 184 | 71 | 1.14 (0.90–1.44) | 1.24 (1.00–1.54) | 0.78 (0.59–1.02) | |
50–64 | 153 | 273 | 316 | 127 | 1.63 (1.34–1.99) | 1.14 (0.97–1.33) | 0.80 (0.65–0.98) | |
>65 | 373 | 510 | 649 | 318 | 1.24 (1.08–1.41) | 1.19 (1.06–1.34) | 0.93 (0.81–1.06) | |
Total |
703 |
988 |
1,185 |
532 |
1.38 (1.26–1.52) |
1.19 (1.09–1.29) |
0.89 (0.81–0.99) |
|
PCV10–7 | ||||||||
<2 | 7 | 6 | 3 | 0 | 0.92 (0.31–2.73) | 0.51 (0.13–2.02) | NC | |
2–4 | 5 | 6 | 2 | 3 | 1.32 (0.40–4.33) | 0.34 (0.07–1.66) | 3.00 (0.50–18.0) | |
5–17 | 5 | 12 | 7 | 2 | 2.40 (0.84–6.81) | 0.59 (0.23–1.49) | 0.58 (0.12–2.77) | |
18–49 | 69 | 78 | 91 | 26 | 1.16 (0.84–1.60) | 1.18 (0.87–1.59) | 0.58 (0.37–0.89) | |
50–64 | 43 | 83 | 97 | 26 | 1.77 (1.22–2.55) | 1.15 (0.86–1.54) | 0.53 (0.35–0.82) | |
>65 | 115 | 114 | 119 | 47 | 0.90 (0.69–1.16) | 0.98 (0.76–1.26) | 0.75 (0.53–1.05) | |
Total |
244 |
299 |
319 |
104 |
1.21 (1.02–1.43) |
1.06 (0.90–1.24) |
0.65 (0.52–0.81) |
|
Non-PCV10 | ||||||||
<2 | 18 | 23 | 10 | 5 | NA | 0.44 (0.21–0.92) | 1.03 (0.35–3.03) | |
2–4 | 2 | 4 | 6 | 1 | NA | 1.51 (0.43–5.35) | 0.33 (0.04–2.77) | |
5–17 | 6 | 5 | 8 | 5 | NA | 1.61 (0.53–4.93) | 1.26 (0.41–3.85) | |
18–49 | 65 | 71 | 93 | 45 | NA | 1.32 (0.97–1.80) | 0.98 (0.68–1.39) | |
50–64 | 110 | 190 | 219 | 101 | NA | 1.13 (0.93–1.37) | 0.92 (0.72–1.16) | |
>65 | 258 | 396 | 530 | 271 | NA | 1.25 (1.10–1.43) | 0.97 (0.84–1.12) | |
Total |
459 |
689 |
866 |
428 |
NA |
1.25 (1.13–1.38) |
0.98 (0.88–1.11) |
|
19A | ||||||||
<2 | 5 | 5 | 0 | 0 | 1.07 (0.31–3.70) | 0.00 (NC) | NC | |
2–4 | 0 | 2 | 1 | 0 | NC | 0.50 (0.05–5.55) | NC | |
5–17 | 0 | 2 | 0 | 0 | NC | 0.00 (NC) | NC | |
18–49 | 1 | 12 | 15 | 3 | 12.3 (1.60–94.6) | 1.26 (0.59–2.69) | 0.40 (0.12–1.39) | |
50–64 | 13 | 28 | 44 | 14 | 1.97 (1.02–3.81) | 1.54 (0.96–2.48) | 0.63 (0.35–1.15) | |
>65 | 25 | 63 | 94 | 33 | 2.28 (1.43–3.62) | 1.40 (1.02–1.92) | 0.66 (0.45–0.99) | |
Total | 44 | 112 | 154 | 50 | 2.50 (1.77–3.55) | 1.36 (1.07–1.74) | 0.65 (0.47–0.89) |
*PCV7, 7-valent pneumococcal conjugate vaccine; PCV10−7, serotypes present in PCV10 but not PCV7 (3 additional serotypes); PCV10, 10-valent pneumococcal conjugate vaccine; CIR, cumulative incidence ratio; NC, not calculated (numbers too low to be informative or relevant). NA, not applicable.