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Volume 21, Number 9—September 2015
THEME ISSUE
Emerging Infections Program

Effect of Culture-Independent Diagnostic Tests on Future Emerging Infections Program Surveillance

Gayle LangleyComments to Author , John Besser, Martha Iwamoto, Fernanda C. Lessa, Alicia Cronquist, Tami H. Skoff, Sandra Chaves, Dave Boxrud, Robert W. Pinner, and Lee H. Harrison
Author affiliations: Centers for Disease Control and Prevention, Atlanta, Georgia, USA (G. Langley, J. Besser, M. Iwamoto, F.C. Lessa, T.H. Skoff, S. Chaves, R.W. Pinner); Colorado Department of Public Health and Environment, Denver, Colorado, USA (A. Cronquist); Minnesota Department of Health, St. Paul, Minnesota, USA (D. Boxrud); Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA (L.H. Harrison)

Main Article

Table 2

Plans for measuring disease burden and analyzing microbiological and molecular characteristics in the era of culture independent diagnostics, Emerging Infections Program*

Plan steps
Conduct periodic laboratory surveys to monitor uptake of tests both within and outside Emerging Infections Program
Develop and continuously evaluate criteria for accepting CIDTs into surveillance case definitions
Consider whether results should be confirmed on all or a subset of detections
Advocate for post-marketing evaluations of CIDTs
Collect individual test types to account for the sensitivity and specificity of CIDTs
Adopt methods to account for changes in testing practices that result from use of CIDTs
Develop an interim strategy for collecting isolates until techniques for serotyping and antimicrobial drug testing on direct patient specimens are available
Assist in the development and provide specimens to collaborators for the development of microbiological and molecular characterization directly from patient specimens
Prepare for use of more advanced techniques, like whole-genome sequencing and metagenomics
Consider performing surveillance for other organisms of public health importance contained in multiplex panels
Contribute to the understanding of when detection equates with true infection

*CIDT, culture-independent diagnostic test.

Main Article

Page created: August 12, 2015
Page updated: August 12, 2015
Page reviewed: August 12, 2015
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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