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Volume 22, Number 10—October 2016
CME ACTIVITY - Synopsis

Infection-Related Death among Persons with Refractory Juvenile Idiopathic Arthritis

Mario AbinunComments to Author , Jonathan P. Lane, Mark Wood1, Mark Friswell, Terence J. Flood, and Helen E. Foster
Author affiliations: Great North Children's Hospital, Newcastle upon Tyne, UK (M. Abinun, J.P. Lane, M. Friswell, T.J. Flood, H.E. Foster); Newcastle University, Newcastle upon Tyne (M. Abinun, H.E. Foster); Leeds General Infirmary, Leeds, UK (M. Wood)

Main Article

Table 2

Laboratory parameters of inflammatory activity for 2 children with juvenile idiopathic arthritis, Newcastle upon Tyne, United Kingdom, 2004*

Patient no., date CRP, mg/dL Ne, × 109 cells/L PLT, × 109/L ESR, mm/h Ferr, μg/L Fib, g/L TG, mmol/L Alb, g/L ALT, U/L Na, mmol/L
Patient 1
Feb 17 100 20.2 322 35 485 5.4 0.7 34 24 142
Feb 28 107 28.5 266 – – – – 31 35 136
Feb 29 157 15.8 140 – – – – 22 48 134
Mar 1
 63
 7.1
 79
 –
 –
 –
 –
 23
 120
 140
Patient 2
May 27 122 17.2 475 45 339 6.3 1.9 44 10 135
Jun 1 260 34.9 603 – 2815 8.0 – 38 23 137
Jun 6 365 37.5 710 105 7692 8.1 – 37 50 134
Jun 10 127 70.5 244 – – 2.9 – 13 125 134

*Laboratory parameters for diagnosing macrophage activation syndrome: Ferr >684 μg/L and any 2 of the following signs: PLT count <181 × 109/L, ALT >48 U/L, TG >156 mg/dL, fibrinogen <360 mg/dL (14). See section in text on MAS versus Multiorgan Failure. Alb, serum albumin level (reference 38–53 g/L); ALT, serum alanine transaminase level (reference 0–40 U/L); CRP, C-reactive protein (reference 0–5 mg/dL); ESR, erythrocyte sedimentation rate (Westergren; reference 1–10 mm/h); Ferr, serum ferritin level (reference 20–60 μg/L); Fib, serum fibrinogen level (reference 1.5–4.0 g/L); Na, serum sodium level (reference 135–145 mmol/L); Ne, absolute neutrophil count; PLT, absolute platelet count; TG, serum triglyceride level (reference 0.5–1.8).

Main Article

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1Current affiliation: Leeds General Infirmary, Leeds, UK.

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