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Volume 22, Number 10—October 2016

Synopsis

Population-Level Effects of Human Papillomavirus Vaccination Programs on Infections with Nonvaccine Genotypes

David MesherComments to Author , Kate Soldan, Matti Lehtinen, Simon Beddows, Marc Brisson, Julia M.L. Brotherton, Eric P.F. Chow, Teresa Cummings, Mélanie Drolet, Christopher K. Fairley, Suzanne M. Garland, Jessica A. Kahn, Kimberley Kavanagh, Lauri E. Markowitz, Kevin G. Pollock, Anna Söderlund-Strand, Pam Sonnenberg, Sepehr N. Tabrizi, Clare Tanton, Elizabeth R. Unger, and Sara L. Thomas
Author affiliations: Public Health England, London, UK (D. Mesher, K. Soldan, S. Beddows); London School of Hygiene and Tropical Medicine, London (D. Mesher, S.L. Thomas); University of Tampere, Tampere, Finland (M. Lehtinen); Imperial College London, London (M. Brisson); Centre de recherche du CHU de Québec, Quebec City, Quebec, Canada (M. Brisson, M. Drolet); Université Laval, Quebec (M. Brisson, M Drolet); Victorian Cytology Service, Melbourne, Victoria, Australia (J.M.L. Brotherton); University of Melbourne, Melbourne (J.M.L. Brotherton, S.M. Garland, S.N. Tabrizi); Melbourne Sexual Health Centre, Melbourne (E.P.F. Chow, C.K. Fairley); Monash University, Melbourne (E.P.F. Chow, C.K. Fairley); Indiana University School of Medicine, Indianapolis, Indiana, USA (T. Cummings); Murdoch Childrens Research Institute, Parkville, Victoria, Australia (S.M. Garland, S.N. Tabrizi); The Royal Women’s Hospital, Melbourne (S.M. Garland, S.N. Tabrizi); Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA (J.A. Kahn); University of Cincinnati College of Medicine, Cincinnati (J.A. Kahn); University of Strathclyde, Glasgow, Scotland, UK (K. Kavanagh); Centers for Disease Control and Prevention, Atlanta, Georgia, USA (L. Markowitz, E. Unger); Health Protection Scotland, Glasgow (K.G. Pollock); Division of Clinical Microbiology, Laboratory Medicine, Skåne, Lund, Sweden (A. Söderlund-Strand); University College London, London (P. Sonnenberg, C. Tanton)

Main Article

Table 2

Summary prevalence ratios for meta-analysis of changes in nonvaccine high-risk HPV types among girls and women, by age group*

Population age group, y, and HPVtype No. studies† Heterogeneity
 Prevalence ratio 
(95% CI)
I2, % p value
≤19
HPV types in nonavalent vaccine 8
HPV31 6.4 0.381 0.73 (0.58–0.91)
HPV33 0 0.471 1.04 (0.78–1.38)
HPV45 5.5 0.387 0.96 (0.75–1.23)
HPV52 24.0 0.238 1.34 (1.13–1.59)
HPV58 0 0.727 1.01 (0.80–1.26)
Other high-risk HPV types 8
HPV35 25.1 0.229 –
HPV39 0 0.984 1.27 (1.05–1.54)
HPV51 43.6 0.088 –
HPV56 74.3 <0.001 –
HPV59 66.8 0.004 –
HPV68 0 0.690 1.26 (0.88–1.81)
Other possibly high-risk HPV types 6
HPV26 0 0.478 1.63 (0.84–3.16)
HPV53 3.6 0.394 1.51 (1.10–2.06)
HPV70 23.6 0.257 1.34 (0.75–2.39)
HPV73 0 0.961 1.36 (1.03–1.80)
HPV82
49.0
 0.081
 –
20–24
HPV types in nonavalent vaccine 8
HPV31 28.8 0.198 –
HPV33 50.9 0.047 –
HPV45 64.3 0.007 –
HPV52 31.0 0.180 –
HPV58 0 0.806 1.14 (0.99–1.31)
Other high-risk HPV types 8
HPV35 7.9 0.369 1.07 (0.85–1.34)
HPV39 0 0.522 1.13 (1.00–1.28)
HPV51 49.8 0.052 –
HPV56 82.6 <0.001 –
HPV59 63.6 0.007 –
HPV68 35.6 0.145 –
Other possibly high-risk HPV types 6
HPV26 44.3 0.110 –
HPV53 30.8 0.204 –
HPV70 25.1 0.246 –
HPV73 59.2 0.032 –
HPV82 38.3 0.151 –

*HPV, human papillomavirus; –, prevalence ratio not calculated because of heterogeneity of data.
†Number of studies was the same for all HPV types within each category.

Main Article

Page created: September 20, 2016
Page updated: September 20, 2016
Page reviewed: September 20, 2016
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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