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Volume 22, Number 11—November 2016
Dispatch

ESBL-Producing and Macrolide-Resistant Shigella sonnei Infections among Men Who Have Sex with Men, England, 2015

Piers MookComments to Author , Jacquelyn McCormick, Manpreet Bains, Lauren A. Cowley, Marie A. Chattaway, Claire Jenkins, Amy Mikhail, Gwenda Hughes, Richard Elson, Martin Day, Rohini Manuel, Jayshree Dave, Nigel Field1, Gauri Godbole1, Timothy J. Dallman2, and Paul Crook2
Author affiliations: Public Health England, London, UK (P. Mook, J. McCormick, M. Bains, L.A. Cowley, M.A. Chattaway, C. Jenkins, A. Mikhail, G. Hughes, R. Elson, M. Day, N. Field, G. Godbole, T. Dallman, P. Crook); Barts Health National Health Service Trust, London (R. Manuel, J. Dave); University College London, London (N. Field)

Main Article

Figure 1

Genomic plot of multidrug-resistance plasmid p183660 (inner ring, blue) from a man in England infected with Shigella sonnei compared with pKSR100 (outer ring, purple), a multidrug-resistance plasmid from a case of S. flexneri 3a infection occurring among men who have sex in men (4). Drug-resistant elements from p183660 are shown in red. Plot produced by using BLAST Ring Image Generator (5).

Figure 1. Genomic plot of multidrug-resistance plasmid p183660 (inner ring, blue) from a man in England infected with Shigella sonnei compared with pKSR100 (outer ring, purple), a multidrug-resistance plasmid from a case of S. flexneri 3a infection occurring among men who have sex in men (4). Drug-resistant elements from p183660 are shown in red. Plot produced by using BLAST Ring Image Generator (5).

Main Article

References
  1. Borg  ML, Modi  A, Tostmann  A, Gobin  M, Cartwright  J, Quigley  C, Ongoing outbreak of Shigella flexneri serotype 3a in men who have sex with men in England and Wales, data from 2009-2011. Euro Surveill. 2012;17:20137.PubMedGoogle Scholar
  2. Simms  I, Field  N, Jenkins  C, Childs  T, Gilbart  VL, Dallman  TJ, Intensified shigellosis epidemic associated with sexual transmission in men who have sex with men—Shigella flexneri and S. sonnei in England, 2004 to end of February 2015. Euro Surveill. 2015;20:21097.DOIPubMedGoogle Scholar
  3. Ashton  P, Nair  S, Peters  T, Tewolde  R, Day  M, Doumith  M, Revolutionising public health reference microbiology using whole genome sequencing: salmonella as an exemplar. bioRxiv. 2015;•••:033225.
  4. Baker  KS, Dallman  TJ, Ashton  PM, Day  M, Hughes  G, Crook  PD, Intercontinental dissemination of azithromycin-resistant shigellosis through sexual transmission: a cross-sectional study. Lancet Infect Dis. 2015;15:913–21.DOIPubMedGoogle Scholar
  5. Alikhan  N-F, Petty  NK, Ben Zakour  NL, Beatson  SA. BLAST Ring Image Generator (BRIG): simple prokaryote genome comparisons. BMC Genomics. 2011;12:402.DOIPubMedGoogle Scholar
  6. Gilbart  VL, Simms  I, Jenkins  C, Furegato  M, Gobin  M, Oliver  I, Sex, drugs and smart phone applications: findings from semistructured interviews with men who have sex with men diagnosed with Shigella flexneri 3a in England and Wales. Sex Transm Infect. 2015;91:598–602.DOIPubMedGoogle Scholar
  7. Baer  JT, Vugia  DJ, Reingold  AL, Aragon  T, Angulo  FJ, Bradford  WZ. HIV infection as a risk factor for shigellosis. Emerg Infect Dis. 1999;5:820–3.DOIPubMedGoogle Scholar
  8. Hoffmann  C, Sahly  H, Jessen  A, Ingiliz  P, Stellbrink  H-J, Neifer  S, High rates of quinolone-resistant strains of Shigella sonnei in HIV-infected MSM. Infection. 2013;41:999–1003.DOIPubMedGoogle Scholar
  9. Bowen  A, Eikmeier  D, Talley  P, Siston  A, Smith  S, Hurd  J, ; Centers for Disease Control and Prevention (CDC). Notes from the field: outbreaks of Shigella sonnei infection with decreased susceptibility to azithromycin among men who have Sex with men—Chicago and Metropolitan Minneapolis–St. Paul, 2014. MMWR Morb Mortal Wkly Rep. 2015;64:597–8.PubMedGoogle Scholar
  10. Public Health England. Shigella: leaflet and poster for men who have sex with men. 2013 Dec 1 [cited 2016 Feb 10]. https://www.gov.uk/government/publications/shigella-leaflet-and-poster

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1These authors contributed equally to this article.

2These senior authors contributed equally to this article.

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Page updated: October 19, 2016
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