Volume 22, Number 11—November 2016
Dispatch
Early Growth and Neurologic Outcomes of Infants with Probable Congenital Zika Virus Syndrome
Antonio Augusto Moura da Silva
, Jucelia Sousa Santos Ganz, Patricia da Silva Sousa, Maria Juliana Rodvalho Doriqui, Marizelia Rodrigues Costa Ribeiro, Maria dos Remédios Freitas Carvalho Branco, Rejane Christine de Sousa Queiroz, Maria de Jesus Torres Pacheco, Flavia Regina Vieira da Costa, Francelena de Sousa Silva, Vanda Maria Ferreira Simões, Marcos Antonio Barbosa Pacheco, Fernando Lamy-Filho, Zeni Carvalho Lamy, and Maria Teresa Seabra Soares de Britto e Alves
, Jucelia Sousa Santos Ganz, Patricia da Silva Sousa, Maria Juliana Rodvalho Doriqui, Marizelia Rodrigues Costa Ribeiro, Maria dos Remédios Freitas Carvalho Branco, Rejane Christine de Sousa Queiroz, Maria de Jesus Torres Pacheco, Flavia Regina Vieira da Costa, Francelena de Sousa Silva, Vanda Maria Ferreira Simões, Marcos Antonio Barbosa Pacheco, Fernando Lamy-Filho, Zeni Carvalho Lamy, and Maria Teresa Seabra Soares de Britto e Alves
Table
Clinical characteristics of probable congenital Zika virus syndrome in infants from birth to 1–8 months of age, Sao Luis, Brazil, 2015–2016
| Characteristic |
No. (%) |
|---|---|
| Rash in mother during pregnancy, n = 46 | |
| First trimester | 24 (52.2) |
| First month | 1 (2.2) |
| Second month | 12 (26.1) |
| Third month | 11 (23.9) |
| Second trimester | 10 (21.7) |
| Fourth month | 9 (19.6) |
| Sixth month | 1 (2.2) |
| No rash |
12 (26.1) |
| Sex, n = 48 | |
| M | 25 (52.1) |
| F |
23 (47.9) |
| Gestational age at birth, n = 47 | |
| Preterm | 4 (8.5) |
| Term | 41 (87.2) |
| Postterm |
2 (4.3) |
| Head circumference z-score at birth,* n = 45 | |
| >–2 | 6 (13.3) |
| Microcephaly, <–2 | 10 (22.2) |
| Severe microcephaly, <–3 |
29 (64.5) |
| Birth length z-score,* n = 3 | |
| >–2 | 21 (56.8) |
| <–2 | 11 (29.7) |
| <–3 |
5 (13.5) |
| Birthweight z-score,* n = 46 | |
| >–2 | 37 (80.4) |
| <–2 | 8 (17.4) |
| <–3 |
1 (2.2) |
| Age at last visit, mo, n = 48 | |
| 1 | 2 (4.2) |
| 2 | 6 (12.5) |
| 3 | 7 (14.6) |
| 4 | 10 (20.8) |
| 5 | 10 (20.8) |
| 6 | 7 (14.6) |
| 7 | 5 (10.4) |
| 8 |
1 (2.1) |
| Phenotype, n = 48 | |
| Craniofacial disproportion | 46 (95.8) |
| Biparietal depression | 40 (83.3) |
| Prominent occiput | 36 (75.0) |
| Excess nuchal skin |
23 (47.9) |
| Signs and symptoms, n = 48 | |
| Irritability | 41 (85.4) |
| Pyramidal/extrapyramidal syndrome | 27 (56.3) |
| Epileptic seizures | 24 (50.0) |
| Dysphagia | 7 (14.6) |
| Congenital clubfoot | 5 (10.4) |
| Arthrogryposis | 5 (10.4) |
| Cleft lip/cleft palate |
1 (2.1) |
| Electroencephalogram findings, n = 27 | |
| Abnormal activity, no epileptiform discharges | 13 (48.1) |
| Focal epileptiform discharges | 8 (29.6) |
| Multifocal epileptiform discharges |
6 (22.2) |
| Cranial computed tomography imaging findings, n = 48 | |
| Calcifications in the brain parenchyma | 44 (91.7) |
| Malformation of cortical development | 42 (87.5) |
| Ventriculomegaly | 37 (77.1) |
| White matter attenuation | 15 (31.3) |
| Brain stem and cerebellum hypoplasia | 6 (12.5) |
*Reported as deviations of the raw z-score from the mean measured in SD units.
Page created: October 19, 2016
Page updated: October 19, 2016
Page reviewed: October 19, 2016
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