Volume 22, Number 3—March 2016
Research
Encephalitis, Ontario, Canada, 2002–2013
Table 3
Variable | No. (%) cases, N = 6,463 | Incidence rate | Multivariable analysis |
||||
---|---|---|---|---|---|---|---|
Ontario, 2002–2013 |
England, 2005–2009† |
||||||
Adjusted IRR (95% CI) | p value | Adjusted IRR (95% CI) | p value | ||||
Sex | |||||||
M | 3,417 (52.8) | 4.6 | Referent | <0.0001 | Referent | 0.002 | |
F |
3,046 (47.1) |
4.0 |
0.9 (0.8–0.9) |
0.9 (0.9–1.0) |
|||
Age group, y | |||||||
<1 | 173 (2.7) | 10.7 | 3.9 (3.3–4.5) | <0.0001 | 3.7 (3.2–4.2) | <0.001 | |
1–4 | 377 (5.8) | 5.7 | 2.1 (1.8–2.3) | 1.9 (1.7–2.1) | |||
5–19 | 915 (14.2) | 3.2 | 1.2 (1.1–1.3) | 0.9 (0.8–1.0) | |||
20–44 | 1,486 (23.0) | 2.8 | Referent | Referent | |||
45–64 | 1,823 (28.2) | 4.4 | 1.6 (1.5–1.8) | 1.4 (1.3–1.5) | |||
>65 | 1,689 (26.1) | 8.3 | 3.0 (2.8–3.2) | 1.9 ( 1.8–2.1) |
*Incidence is number of cases/100,000 persons. IRR, incident rate ratio.
†Reference (1).
References
- Schmidt A, Bühler R, Mühlemann K, Hess CW, Täuber MG. Long-term outcome of acute encephalitis of unknown aetiology in adults. Clin Microbiol Infect. 2011;17:621–6 . DOIPubMedGoogle Scholar
- Khetsuriani N, Holman RC, Anderson LJ. Burden of encephalitis-associated hospitalizations in the United States, 1988–1997. Clin Infect Dis. 2002;35:175–82 . DOIPubMedGoogle Scholar
- Vora NM, Holman RC, Mehal JM, Steiner CA, Blanton J, Sejvar J. Burden of encephalitis-associated hospitalizations in the United States, 1998–2010. Neurology. 2014;82:443–51 . DOIPubMedGoogle Scholar
- Kulkarni MA, Comtois Lecocq A, Artsob H, Drebot MA, Ogden NH. Epidemiology and aetiology of encephalitis in Canada, 1994–2008: a case for undiagnosed arboviral agents? Epidemiol Infect. 2013;141:2243–55 . DOIPubMedGoogle Scholar
- Barbadoro P, Marigliano A, Ricciardi A, D'Errico MM, Prospero E. Trend of hospital utilization for encephalitis. Epidemiol Infect. 2012;140:753–64 . DOIPubMedGoogle Scholar
- Huppatz C, Durrheim DN, Levi C, Dalton C, Williams D, Clements MS, Etiology of encephalitis in Australia, 1990–2007. Emerg Infect Dis. 2009;15:1359–65. DOIGoogle Scholar
- Granerod J, Ambrose HE, Davies NWS, Clewley JP, Walsh AL, Morgan D, Causes of encephalitis and differences in their clinical presentations in England: a multicentre, population-based prospective study. Lancet Infect Dis. 2010;10:835–44 . DOIPubMedGoogle Scholar
- Kelly TA, O’Lorcain P, Moran J, Garvey P, McKeown P, Connell J, Underreporting of viral encephalitis and viral meningitis, Ireland, 2005–2008. Emerg Infect Dis. 2013;19:1428–36 . DOIPubMedGoogle Scholar
- Bitnun A, Richardson SE. Childhood encephalitis in Canada in 2015. Can J Infect Dis Med Microbiol. 2015;26:69–72 .PubMedGoogle Scholar
- Lindgren E, Gustafson R. Tick-borne encephalitis in Sweden and climate change. Lancet. 2001;358:16–8 . DOIPubMedGoogle Scholar
- Campbell GL, Marfin AA, Lanciotti RS, Gubler DJ. West Nile virus. Lancet. 2002;2:519–29 . DOIPubMedGoogle Scholar
- Honnorat E, De Broucker T, Mailles A, Stahl JP. Le Comité de Pilotage et Groupe des Investigateurs. Encephalitis due to Mycobacterium tuberculosis in France. Med Mal Infect. 2013;43:230–8 . DOIPubMedGoogle Scholar
- Government of Ontario. Infectious diseases protocol appendix A: disease-specific chapters. 2009 [cited 2015 Sep 1]. http://www.health.gov.on.ca/en/pro/programs/publichealth/oph_standards/docs/encephalitis_chapter.pdf
- Government of Ontario Ministry of Health and Long-Term Care. Appendix B: provincial case definitions for reportable diseases. 2009 [cited 2015 Sep 1]. http://www.health.gov.on.ca/en/pro/programs/publichealth/oph_standards/docs/encephalitis_cd.pdf
- Granerod J. Encephalitis in England: incidence and cause. London: London School of Hygiene and Tropical Medicine; 2011.
- Vora NM, Holman RC, Mehal JM, Steiner CA, Blanton J, Sejvar J. Burden of encephalitis-associated hospitalizations in the United States, 1998–2010. Neurology. 2014;82:443–51 . DOIPubMedGoogle Scholar
- Granerod J, Cousens S, Davies NWS, Crowcroft NS, Thomas SL. New estimates of incidence of encephalitis in England. Emerg Infect Dis. 2013;19:1455–62 . DOIPubMedGoogle Scholar
- Kwong JC, Li P, Redelmeier DA. Influenza morbidity and mortality in elderly patients receiving statins: a cohort study. PLoS ONE. 2009;4:1–6. DOIGoogle Scholar
- Granerod J, Crowcroft NS. The epidemiology of acute encephalitis. Neuropsychol Rehabil. 2007;17:406–28 . DOIPubMedGoogle Scholar
- Davison KL, Crowcroft NS, Ramsay ME, Brown DWG, Andrews NJ. Viral encephalitis in England 1989–1999: what did we miss? Emerg Infect Dis. 2003;9:234–40 . DOIPubMedGoogle Scholar
1Current affiliation: Yale School of Public Health, New Haven, Connecticut, USA.
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