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Volume 22, Number 4—April 2016
Research

Microevolution of Monophasic Salmonella Typhimurium during Epidemic, United Kingdom, 2005–2010

Liljana Petrovska, Alison E. Mather1, Manal AbuOun, Priscilla Branchu, Simon R. Harris, Thomas Connor, K.L. Hopkins, A. Underwood, Antonia A. Lettini, Andrew J. Page, Mary Bagnall, John Wain, Julian Parkhill, Gordon Dougan, Robert Davies, and Robert A. KingsleyComments to Author 
Author affiliations: Animal and Plant Health Agency, Addlestone, UK (L. Petrovska, M. AbuOun, M. Bagnall, R. Davies); The Wellcome Trust Sanger Institute, Cambridge, UK (A.E. Mather, S.R. Harris, T. Connor, A. Page, J. Parkhill, G. Dougan, R.A. Kingsley); Institute of Food Research, Norwich, UK (P. Branchu, R.A. Kingsley); Public Health England, London, UK (K.L. Hopkins, A. Underwood, J. Wain); Istituto Zooprofilattico Sperimentale delle Venezie, Legnaro (PD), Italy (A.A. Lettini)

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Figure 1

Phylogeny of Salmonella enterica serovar Typhimurium (Salmonella Typhimurium) and Salmonella 1,4,[5],12:i:- isolates from the United Kingdom and Italy, 2005–2010. Maximum-likelihood tree of 212 Salmonella Typhimurium and monophasic isolates was constructed by using 12,793 single-nucleotide polymorphisms (SNPs) outside of prophage elements, insertion sequence elements and sequence repeats identified by reference to the whole-genome sequence of Salmonella Typhimurium strain SL1344. The tree is roo

Figure 1. Phylogeny of Salmonella enterica serovar Typhimurium (Salmonella Typhimurium) and Salmonella 1,4,[5],12:i:- isolates from the United Kingdom and Italy, 2005–2010. Maximum-likelihood tree of 212 Salmonella Typhimurium and monophasic isolates was constructed by using 12,793 single-nucleotide polymorphisms (SNPs) outside of prophage elements, insertion sequence elements and sequence repeats identified by reference to the whole-genome sequence of Salmonella Typhimurium strain SL1344. The tree is rooted with Salmonella Enteritidis whole-genome sequence as an outgroup (note shown). The lineage containing the Salmonella 1,4,[5],12:i:- current UK epidemic group is conflated for simplicity (filled triangle). The designation of the isolates (left column) and phage type are shown (right column). *Monophasic isolates outside of the main epidemic clade. †Monophasic clade closely related to the monophasic clone CVM23701 from North America (9). DT, definitive (phage) type; ND, not determined. Scale bar indicates the approximate number of SNPs determined by genetic distance and the number of SNPs used to construct the tree.

Main Article

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1Current affiliation: University of Cambridge, Cambridge, UK.

Page created: December 01, 2016
Page updated: December 01, 2016
Page reviewed: December 01, 2016
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