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Volume 22, Number 6—June 2016
Research

High MICs for Vancomycin and Daptomycin and Complicated Catheter-Related Bloodstream Infections with Methicillin-Sensitive Staphylococcus aureus

Rafael San-JuanComments to Author , Esther Viedma, Fernando Chaves, Antonio Lalueza, Jesús Fortún, Elena Loza, Miquel Pujol, Carmen Ardanuy, Isabel Morales, Marina de Cueto, Elena Resino-Foz, Alejandra Morales-Cartagena, Alicia Rico, María P. Romero, María Ángeles Orellana, Francisco López-Medrano, Mario Fernández-Ruiz, and José María Aguado
Author affiliations: University Hospital–Research Institute 12 de Octubre, Madrid, Spain (R. San-Juan, E. Viedma, F. Chaves, A. Lalueza, E. Resino-Foz, A. Morales-Cartagena, M.Á. Orellana, F. López-Medrano, M. Fernández-Ruiz, J. María Aguado); Hospital Universitario Ramón y Cajal, Madrid (J. Fortún, E. Loza); University Hospital–Bellvitge Institute for Biomedical Research, Barcelona, Spain (M. Pujol, C. Ardanuy); Hospital Universitario Virgen de la Macarena, Seville, Spain (I. Morales, M. de Cueto); Hospital Universitario La Paz, Madrid (A. Rico, M.P. Romero)

Main Article

Table 5

Univariate and multivariate analyses of risk factors for development of complicated methicillin-sensitive Staphylococcus aureus catheter-related bloodstream infection*

Variable
 Univariate, HR (95% CI)
Multivariate, HR (95% CI)†
Recruiting center 1 3.6 (1.6–8.1) –
Any daptomycin-containing empiric therapy 2.5 (1.1–5.7) –
Daptomycin monotherapy as empiric therapy 3.1 (1.3–7.1) –
Vancomycin MIC >1.5 μg/mL 2.6 (1.1–5.9) 2.4 (1.2–5.5)
Daptomycin MIC >0.5 μg/mL 3.4 (1.6–8.2) 2.4 (1.1–5.9)

*HR, hazard ratio; –, corresponding variables were not retained in the final model.
†Various models, including a maximum of 3 variables, were explored that combined all statistically significant variables identified at the univariate level. Only variables that were constantly retained in these models are shown with minimum HR values obtained.

Main Article

Page created: May 16, 2016
Page updated: May 16, 2016
Page reviewed: May 16, 2016
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