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Volume 22, Number 6—June 2016
Dispatch

Changes in Childhood Pneumonia Hospitalizations by Race and Sex Associated with Pneumococcal Conjugate Vaccines

Andrew D. WieseComments to Author , Carlos G. Grijalva, Yuwei Zhu, Edward F. Mitchel, and Marie R. Griffin
Author affiliations: Vanderbilt University Medical Center, Nashville, Tennessee, USA (A.D. Wiese, C.G. Grijalva, Y. Zhu, E.F. Mitchel Jr, M.R. Griffin); VA Tennessee Valley Healthcare System, Nashville (C.G. Grijalva, M.R. Griffin)

Main Article

Table

Pre-PCV7 and post-PCV13 annualized pneumonia rates, by age, sex, and race, and hospitalizations per 1,000 children, Tennessee, USA, 1998–2013*

Patient age, y, and race Patient sex Hospitalizations/1,000 children
Post-PCV13 vs. pre-PCV7
Pre-PCV7, 1998–1999, 11,059 hospitalizations Post-PCV13, 2011–2013, 9,171 hospitalizations Rate ratio 
(95% CI) Rate difference 
(95% CI)†
All‡

4.0
2.0

0.51 (0.50–0.52)
−2.0 (−2.1 to −1.9)
<2‡ 18.4 7.3 0.40 (0.38–0.41) −11.1 (−11.6 to −10.6)
Black M 27.1 8.5 0.31 (0.28–0.35) −18.6 (−20.5 to −16.6)
Black F 20.0 6.4 0.32 (0.28–0.37) −13.6 (−15.3 to −11.9)
White M 18.0 7.8 0.43 (0.40–0.46) −10.2 (−11.1 to −9.3)
White
F
14.5
6.2

0.43 (0.40–0.47)
−8.2 (−9.0 to −7.4)
2–4‡ 5.4 3.0 0.56 (0.52–0.59) −2.4 (−2.6 to −2.1)
Black M 6.6 3.4 0.50 (0.43–0.59) −3.3 (−4.1 to −2.5)
Black F 5.3 3.1 0.58 (0.49–0.70) −2.2 (−3.0 to −1.5)
White M 5.3 3.0 0.56 (0.51–0.62) −2.3 (−2.7 to −1.9)
White
F
5.0
2.9

0.59 (0.53–0.65)
−2.0 (−2.4 to −1.6)
5–17‡ 1.6 1.1 0.67 (0.63–0.70) −0.5 (−0.6 to −0.5)
Black M 2.0 1.1 0.57 (0.49–0.65) −0.8 (−1.1 to −0.6)
Black F 1.6 1.0 0.61 (0.53–0.71) −0.6 (−0.8 to −0.4)
White M 1.6 1.1 0.70 (0.65–0.75) −0.5 (−0.6 to −0.4)
White F 1.6 1.2 0.74 (0.68–0.80) −0.4 (−0.5 to −0.3)

*PCV7, 7-valent pneumococcal conjugate vaccine; PCV13, 13-valent pneumococcal conjugate vaccine.
†For hospitalizations per 1,000 children.
‡Includes all race/ethnicity categories (black, white, Hispanic, other). These estimates were not different from estimates including only black and
white children.

Main Article

Page created: August 18, 2016
Page updated: August 18, 2016
Page reviewed: August 18, 2016
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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