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Volume 22, Number 7—July 2016
Letter

Naturally Circulating Hepatitis A Virus in Olive Baboons, Uganda

Andrew J. Bennett, Samuel D. Sibley, Michael Lauck, Geoffrey Weny, David Hyeroba, Alex Tumukunde, Thomas C. Friedrich, David H. O’Connor, Caley A. Johnson, Jessica M. Rothman, and Tony L. GoldbergComments to Author 
Author affiliations: University of Wisconsin, Madison, Wisconsin, USA (A.J. Bennett, S.D. Sibley, T.L. Goldberg); Wisconsin National Primate Research Center, Madison (M. Lauck, T.C. Friedrich, D.H. O’Connor, T.L. Goldberg); Makerere University, Kampala, Uganda (G. Weny, D. Hyeroba, A. Tumukunde, J.M. Rothman, T.L. Goldberg); Graduate Center of City University of New York, New York, New York, USA (C.A. Johnson, J.M. Rothman); New York Consortium in Evolutionary Primatology, New York (C.A. Johnson, J.M. Rothman); Hunter College of the City University of New York, New York (J. Rothman).

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Figure

Whole-genome phylogenetic reconstruction of representative HAVs. HAVs are grouped into 6 genotypes based on 168 bp of the C-terminal extension of the viral protein 1 gene. Baboon HAV detected in Kibale National Park, Uganda, in 2010 and 2014 (GenBank accession number KT819575) clusters with AGM-27 (3), previously the sole member of genotype V. jModeltest 2 (http://jmodeltest.org) was used to find the best-fit evolutionary model for the data, after which the maximum-likelihood tree was estimated

Figure. Whole-genome phylogenetic reconstruction of representative HAVs. HAVs are grouped into 6 genotypes based on 168 bp of the C-terminal extension of the viral protein 1 gene. Baboon HAV detected in Kibale National Park, Uganda, in 2010 and 2014 (GenBank accession number KT819575) clusters with AGM-27 (3), previously the sole member of genotype V. jModeltest 2 (http://jmodeltest.org) was used to find the best-fit evolutionary model for the data, after which the maximum-likelihood tree was estimated using the heuristic search method in PAUP* (http://paup.csit.fsu.edu), with starting trees obtained by neighbor-joining, random stepwise addition, and branch swapping by tree-bisection reconnection and starting branch lengths obtained using Rogers-Swofford approximation. Bootstrap values were derived from 1,000 replicates of the heuristic search; only values >50% are shown. GenBank accession nos.: IA, EF207320; IB, M14707; II, AY644676; IIIA, FJ227135; IIIB, AB258387; V, D00924). HAV, hepatitis A virus. Scale bar indicates substitutions per site.

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