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Volume 22, Number 8—August 2016

Asymptomatic Plasmodium Infections in Children in Low Malaria Transmission Setting, Southwestern Uganda1

Michelle E. Roh2, Caesar Oyet2, Patrick Orikiriza, Martina Wade, Gertrude N. Kiwanuka, Juliet Mwanga-Amumpaire, Sunil Parikh3Comments to Author , and Yap Boum3
Author affiliations: University of California, San Francisco, California, USA (M.E. Roh); Yale School of Public Health, New Haven, Connecticut, USA (M.E. Roh, M. Wade, S. Parikh); Mbarara University of Science and Technology, Mbarara, Uganda (C. Oyet, G.N. Kiwanuka, Y. Boum II); Médecins Sans Frontières Epicentre Mbarara Research Centre, Mbarara (P. Orikiriza, J. Mwanga-Amumpaire, Y. Boum II)

Main Article

Table 2

Diagnostic performance of RDT and microscopy for Plasmodium infections in children in 3 districts, southwestern Uganda*

Diagnostic accuracy of RDT† Plasmodium infection P. falciparum infection Non–P. falciparum infection‡
Sensitivity (95% CI) 63.6 (40.7–82.8) 75.0 (42.8–94.5) 10.0 (0.3–44.5)
Specificity (95% CI) 95.4 (93.4–96.9) 95.1 (93.1–96.7) 99.8 (99.1–100.0)
PPV (95% CI) 33.3 (19.6–49.5) 23.1 (11.1–39.3) 50.0 (1.3–98.7)
NPV (95% CI) 98.6 (97.3–99.4) 99.5 (98.5–99.9) 98.6 (97.3–99.3)
Agreement, % 94.3 94.8 98.3
*NPV, negative predictive value; PPV, positive predictive value; RDT, rapid diagnostic test.
†SD Bioline Malaria Ag Pf/Pan (P. falciparum or other Plasmodium species; Standard Diagnostics, Gyeonggi-do, South Korea).
‡Children with mixed infections were excluded from analysis.

Main Article

1Preliminary results from this study were presented at the 64th Annual Meeting of the American Society of Tropical Medicine and Hygiene, October 25–29, 2015, Philadelphia, Pennsylvania, USA.

2These first authors contributed equally to this article.

3These senior authors contributed equally to this article.

Page created: July 15, 2016
Page updated: July 15, 2016
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