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Volume 22, Number 9—September 2016

Bifidobacterium longum Subspecies infantis Bacteremia in 3 Extremely Preterm Infants Receiving Probiotics

Eirin EsaiassenComments to Author , Pauline Cavanagh, Erik Hjerde, Gunnar S. Simonsen, Ragnhild Støen, and Claus Klingenberg
Author affiliations: University Hospital of North Norway, Tromsø, Norway (E. Esaiassen, P. Cavanagh, G.S. Simonsen, C. Klingenberg); Arctic University of Norway, Tromsø (E. Esaiassen, E. Hjerde, G.S. Simonsen, C. Klingenberg); St. Olavs Hospital, Trondheim, Norway (R. Støen); Norwegian University of Science and Technology, Trondheim (R. Støen)

Main Article


Characteristics of 3 extremely preterm infants with Bifidobacterium longum subspecies infantis bacteremia, 2015*

Characteristic Patient 1 Patient 2 Patient 3
Sex M M F
Date of onset Apr Jul Sep
Gestational age, wk 24 23 24
Birth weight, g 730 500 697
Mode of delivery Vaginal Vaginal Caesarean section
Apgar score at 1, 5, and 10 min after birth 4, 5, 5 Unknown, 0, 4 2, 2, 3
Reason for prematurity Preterm rupture of membranes, maternal infection Sudden preterm rupture of membranes, delivery not attended by healthcare personnel Placental abruption
Age at onset of sepsis, d 8 12 46
Maximum CRP level, mg/L, <48 h of symptom onset 147 25 242
Age at discharge, wk 40 41 43
Weight at discharge, kg 3.3 3.4 3.3
Bacterial culture medium and conditions BacT/ALERT,† aerobic, 36°C BACTEC Plus,† aerobic, 35°C BacT/ALERT,† aerobic, 36°C
Bacterial growth in blood culture, d 2 3 2

*Patients were given ½ to 1 capsule/day of oral probiotics (Infloran; Laboratorio Farmacéutico Specialità Igienico Terapeutiche, Mede, Italy) that contained 109 Lactobacillus acidophilus (ATCC 4356) and 109 B. longum subspecies infantis (ATCC 15697). MICs (mg/L) for antimicrobial drugs tested were 0.016 for meropenem, 0.032 for ampicillin, 0.064 for penicillin, 0.064 for piperacillin/tazobactam, 0.250 for cefotaxime, 0.250 for clindamycin, 0.250 for vancomycin, and 4.000 for ciprofloxacin. All bacterial strains were inherently resistant to aminoglycosides. ATCC, American Type Culture Collection (Manassas, VA, USA); CRP, C-reactive protein; NICU, neonatal intensive care unit.
†bioMérieux (Marcy l’Étoile, France).

Main Article

Page created: August 16, 2016
Page updated: August 16, 2016
Page reviewed: August 16, 2016
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